Dopamine Assosciated Aging

[Psychedelics_r_best]

We all know it is relatively rare, but there are those subjects who, when exposed to high levels of amphetamine use seem to age faster, with adverse symptoms assosciated with those of parkinsons disease. Amphetamines cause a surge of dopamine and norephinephrine in the brain synapses.

Well I was thinking that all out evolutionary predecessors, experienced shorter lifespans than current humans, even those of our same species that lived in much more inhospitable climates than we do now. I recall that these lifespans were maxed out at around 3o years.

I was just thinking about it, and perhaps this is simply due to to that fact that they lived in caused a much higher frequency of events in which the "flight or fight" response was necessary. The high levels of dopamine released needed tp cope with these situations could have simply triggered other metabolic pathways that caused the subject to age that much faster than the average human living today, who have to deal with little such situations.

what do you guys think, or do you just think this is a complete hogwash of an idea?

 

[Slay]

i dont think fight or flight response wasnt that effective on human evolution. i'm not sure this response like responses which help dopamine production was something to do with aging process or not. but the major thing imo is the medicine. in 20th centuriy we found amazing things, like penicillin, organ transplantation, defibrillator and much more life saving technologies. back in the day people die from a simple flu, now you just eat some magic pills and youll be fine again i'm not sure about dopamine makes you age faster or not

 

[Smyth]

My buddy is interested in anti-aging stuff.

http://www.ted.com/index.php/talks/view/id/39

He's more interested in stuff that stops DNA mutations.

Powerful antioxidants is obvious enough but he had some other stuff up his sleeve.

I tried saying the irreversible MAO(B) inhibitor selegiline increases the life of a fly but he had doubts that it would work in an analogous fashion with rodents.

There is a competition with some sort of prize for doing this. I'll try and find out more infos later.

Btw, selegiline is a lame drug. If you like mdpv the chances are u'll like it, but it makes u tweak without being buzzy if that means anything to u. It gave me subjective hypertension a few times and definately increased locomotor activity (LMA). I dont have any machine for measuring blood pressure (BP) or my pulse though but I was not impressed with it.

 

[LuxEtVeritas]

SEL isn't really a rec at all, BUT if you want to stay healthy than take it with any agents that have any tendency to cause neurodegeneration as I have said before (low-moderate dose)

 

[Ham-milton]

I never noticed anything adverse about selegiline, but I never stayed on it for too long.

 

[narutokun]

We all know it is relatively rare, but there are those subjects who, when exposed to high levels of amphetamine use seem to age faster, with adverse symptoms assosciated with those of parkinsons disease. Amphetamines cause a surge of dopamine and norephinephrine in the brain synapses.

Well I was thinking that all out evolutionary predecessors, experienced shorter lifespans than current humans, even those of our same species that lived in much more inhospitable climates than we do now. I recall that these lifespans were maxed out at around 3o years.

I was just thinking about it, and perhaps this is simply due to to that fact that they lived in caused a much higher frequency of events in which the "flight or fight" response was necessary. The high levels of dopamine released needed tp cope with these situations could have simply triggered other metabolic pathways that caused the subject to age that much faster than the average human living today, who have to deal with little such situations.

what do you guys think, or do you just think this is a complete hogwash of an idea?

the whole idea is just stupid imo. ppl obviously have much stress than they did in the past, hence more norepinephrine activity if that really even matters. lifespan was expanded because of the advances in medicine, living less had nothing to do with ppl needing to be more alert because they were exposed to more dangers or shit. please. you want more danger than having a gun pointed at your face?

 

[Ham-milton]

What are you talking about? Stress levels are certainly much lower now than at any point in history.

A gun pointed in your face is a rare occurence. Our brethren would have had to struggle just to get daily food, not to mention wild animals and everything else they'd have to have worried about.

 

[LuxEtVeritas]

^ true but we are exposed to media that makes it sem like everything in life shoud; be easy and that everyone else has a better lot and all the barrage of the rich, famous and the like and thus expectation, attitiude, and preparedness ofr the harsh pressure of today's more competitive and ego-deflating workld indeed likely I believe imposes a greater stress condition on people of today than in the past even though they may have had many greater actual TRUE hardships....comprendes?

 

[Ham-milton]

The sorts of stressors you're talking about don't trigger fight or flight responses, though, and don't lead to an early grave.

 

[narutokun]

The sorts of stressors you're talking about don't trigger fight or flight responses, though, and don't lead to an early grave.

lol? you're kidding right?

 

[qwe]

We all know it is relatively rare, but there are those subjects who, when exposed to high levels of amphetamine use seem to age faster, with adverse symptoms assosciated with those of parkinsons disease. Amphetamines cause a surge of dopamine and norephinephrine in the brain synapses.

Well I was thinking that all out evolutionary predecessors, experienced shorter lifespans than current humans, even those of our same species that lived in much more inhospitable climates than we do now. I recall that these lifespans were maxed out at around 3o years.

I was just thinking about it, and perhaps this is simply due to to that fact that they lived in caused a much higher frequency of events in which the "flight or fight" response was necessary. The high levels of dopamine released needed tp cope with these situations could have simply triggered other metabolic pathways that caused the subject to age that much faster than the average human living today, who have to deal with little such situations.

what do you guys think, or do you just think this is a complete hogwash of an idea?

fight or flight response = more mitochondria active in muscles and nervous system = more free radicals = more damage = more aging

 

[kidamnesiac]

the idea that people didn't live past 30 is silly, humans have always been capable of living over 50 without a miracle, many greeks lived well into their 60's and they didn't have dialysis machines and quadruple bypasses.

look at the bible, the old testament people lived for 600 years with no problems, begetting son after son after son

i thought there were studies showing mice lived 30% longer on selegiline...can't find it with a quick search though...but if you think dopamine causes a quicker death, and selegiline increases dopamine levels by decreasing metabolism, wouldn't mice/flies die faster if they were taking selegiline?

 

[Ham-milton]

lol? you're kidding right?

Of course not. Do you really think that worrying about your mortgage produces the same response being chased by a tiger? Besides the freak gun-to-head hold ups, modern times aren't exactly replete with the sorts of events that produce a real fight or flight reaction.

 

[Adrenochrome]

I think(half-assed-idly-hypothesize) that a little stressor helps organisms in some way, if this is true then I'd think that it'd be especially humans because of the plasticity of the human brain

 

[Psychedelics_r_best]

I'm talking about early Homo genus animals, not Homo Sapiens. Remember Homo Erectus, Cro Magnon's. Maybe early pre civilized Homo Sapiens as well. I am not taking about 10,000BC to the the present, I am talking 100,000 BC or prior to 1,000 B.C

 

[LuxEtVeritas]

to the original post/intent of discussion no that is not why and gleaning through any books on the subject will note multiple reasons otherwise

 

[qwe]

^aging is a dynamic process with many factors, so you're right in saying fight/flight response is not the whole issue with aging, but it is a key component

however, youre right that dopamine has little to do with it. HOWEVER extra dopamine does lead to more free radicals in the brain... correct me if im wrong but its breakdown products arent the funnest chemicals to be floating around in your nervous tissue

 

[Adrenochrome]

There is an "end replication problem" theory, it's kinda unrelated to discussion here, but it's an interesting theory.

 

[Ham-milton]

I kinda think that any attempt to extrapolate the aging amphetamines induce with periodic fight-or-flight responses is a bit like associating my daily rain dances with the snow. My results would look better if I was in Seatle, but the change would be due to other factors, not just because I'd be within ear-shot of God, though the benefits of that are a bit undeniable.

 

[Adrenochrome]

I posture that most "amphetamine induced aging" is a great example of the nocebo effect.