Does the effect of methamphetamine differ when taken nasal versus oral (as happens with methylphenidate)?

[JohnBoy2000]

I understand.

I was curious basically whether oral versus nasal elicited some kind of "pro-drug" effect, but apparently meth/ritalin don't work like that.

It would be exclusively pharmacokinetics, time to max concentration and half life associated with the ROA that would cause the actual difference in drug effect.

Fact remains - meth for me, oral I never had the "emotional crash", nasal I had an obscene "emotional crash".

That may have been relevant to lifestyle/emotional changes in between dosing oral versus nasal, but I guess I'll never know cause I swore I'd never use that horribleness again after I went into panic/tachycardia/psychosis and existential crises after my last (and only) nasal binge.

Kind of a shame cause meth for me did what apparently LSD/ketamine does for others - lovely relaxed perspective on life and living.

But the possibility of acquiring indefinite drug induced psychosis/schizophrenia, just doesn't make it seem worth it.

 

[JohnBoy2000]

Describes meth withdrawal so accurately.

 

[emkee_reinvented]

My advive take it oral, if you must. Smoother come up and down

 

[Keif' Richards]

Hey @JohnBoy2000

It's my personal opinion that the whole "Methylphenidate is like Cocaine when snorted" is a bunch of nonsense. It comes from the same book of stories as "Oxycontin is Oxycodone made non-addictive". I always used to hear this in High School when discussing Methylphenidate with kids. The majority of them got that information either directly from their prescriber or from efforts of the producers of Methylphenidate (Ritalin) to make it seem safer than it actually is.

As drugs go, I know there are different things going on out there in that ether that we don't yet know or understand, but most drugs are drugs and the only different between different routes of administration concerns pharmacokinetics and a faster rise or fall due to a faster and greater presence in the bloodstream.

I think Methamphetamine is analogous to Methylphenidate in this way as most will also consider Methamphetamine to be more recreational by the intranasal route than by the oral route, which is also the case with most every substance of abuse.

 

[SpiralusSancti]

I tried methylphenidate orally and don’t regret at all I didn’t try snorting it, it was euphoric and great experience without compulsion to redose.

When I was using ethylphenidate I was usually snorting and it was more potent and hit faster that way but overall oral route was almost as good. Nothing like comparing snorting and eating cocaine, and even that is more thing of costly substance and like Keif Richard said for reasons like with most every substance of abuse.
Pure unadulterated coke is great orally when you take enough and don’t have huge tolerance and ime oral and snorting it isn’t that different qualitatively, it's not a lot more than different from using other drugs nasally vs. orally (quantity for good experience resembling snorting does require much more tho) , while smoking it, that’s another story, that really does feel like a different substance.

 

[G_Chem]

I tried methylphenidate orally and don’t regret at all I didn’t try snorting it, it was euphoric and great experience without compulsion to redose.

When I was using ethylphenidate I was usually snorting and it was more potent and hit faster that way but overall oral route was almost as good. Nothing like comparing snorting and eating cocaine, and even that is more thing of costly substance and like Keif Richard said for reasons like with most every substance of abuse.
Pure unadulterated coke is great orally when you take enough and don’t have huge tolerance and ime oral and snorting it isn’t that different qualitatively, it's not a lot more than different from using other drugs nasally vs. orally (quantity for good experience resembling snorting does require much more tho) , while smoking it, that’s another story, that really does feel like a different substance.

I gotta disagree, Cocaine orally is a lot different. Much of it is metabolized before it gets where it needs to go..

Now sublingually.. That’s not far off from snorted. I use this often to try and save my nose. Only problem is my mouth goes completely numb and I can barely talk or swallow.

What did you think of ethylphenidate? I didn’t like methylphenidate, will I probably also not like the ethyl?

-GC

 

[SpiralusSancti]

I liked ethylphenidate more certainly. I combined methylphenidate with a few beers every time few times I did it as friend convinced me it makes it a lot more euphoric, idk if it’s so but and I did drank them, same like me, he at the time almost never drank alcohol so I took his word. And if that was so in fact, maybe without alcohol methylphenidate shines a lot less than ethyl. So in short, I think you could love ethyl even if you didn’t methyl..

As for coke, I don’t know how you tried it but I used to love popping a couple of capsules with 150 – 250mg or something like that. It was pure coke, stuff that you don’t snort lines without tolerance but bump now and there is enough. Sadly that can turn into fat lines in a rate that was previously unknown to me, with any other substance. Like at first gram can be enough for days of being high as a kite and than before you know it you can snort a line enough for 10 without tolerance. I’m not a big fan of coke honestly but found myself addicted to it kinda in a way it happened with cigarettes. I’m not implying similarity beyond such a high addictivity and losing of effects rapidly once you start doing it regularly. I wont ever allow myself to become addicted to any stimulant, coke or some I like a lot more . Maybe there isn’t much of physical addiction but damn, it’s not that hard at all to end up using mentally dangerous doses both from a binge and using just a little for long enough.

 

[ninjapirateroberts]

I've taken meth orally, sublingually, and also smoked it.

Oral: Best for therapeutic benefits (if you've ADHD or ADD), smooth onset (~20 minutes), decent offset (comedown usually gives me anxiety but rarely panic). Lasts longer than any other route, best for dosing accurately.

Sublingually: Sudden onset (20 seconds), heavy hit (kicks off anxiety, tachycardia, and had panic attacks whenever I tried to take it sublingually), usually needed less dose due to high bioavailability. Not good enough for dosing and is not the best experience.

Smoking it up: Worst for accurate dosing. Only keeps me awake, and I literally don't wanna work (with oral, meth makes me force myself to do something productive). Comedown gave me a panic attack. I have only smoked meth 3-4 times when I'm experimenting with a bunch of stuff. But again, I'm not chasing euphoric high; the reason I use meth is different.

So I think onset and bioavailability is the biggest difference between taking meth orally, nasally, sublingually, or smoking it up which will influence your subjective experience.

 

[emkee_reinvented]

Hey @JohnBoy2000

It's my personal opinion that the whole "Methylphenidate is like Cocaine when snorted" is a bunch of nonsense. It comes from the same book of stories as "Oxycontin is Oxycodone made non-addictive". I always used to hear this in High School when discussing Methylphenidate with kids. The majority of them got that information either directly from their prescriber or from efforts of the producers of Methylphenidate (Ritalin) to make it seem safer than it actually is.

As drugs go, I know there are different things going on out there in that ether that we don't yet know or understand, but most drugs are drugs and the only different between different routes of administration concerns pharmacokinetics and a faster rise or fall due to a faster and greater presence in the bloodstream.

I think Methamphetamine is analogous to Methylphenidate in this way as most will also consider Methamphetamine to be more recreational by the intranasal route than by the oral route, which is also the case with most every substance of abuse.

Both I snorted and although Coke is way more euphoric and lacks the binders they are pretty much the same. So I dis agree with you.


But our Cocaine is almost pure and Serotonergic, and Methylpjeidate isn´t