Does Testosterone make you high?

in the sense of well being and walking into a room and wanting to fuck everyone, yes it can be intoxicating.
 
testosterone has nothing to do with GABA receptors, more like our consciousness as a whole.

its not psychoactive, more like a smart drug but for the endocrine system.

hmm, that is the gaba after all... crazy
 
cityturbo said:
testosterone has nothing to do with GABA receptors, more like our consciousness as a whole.
Click to expand...

Oh Really:

anbolic steroids induce region- and subunit-specific rapid modulation of GABA(A) receptor-mediated currents in the rat forebrain.
Jorge-Rivera JC, McIntyre KL, Henderson LP.
Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
• J Neurophysiol. 2007 Sep;98(3):1841.

Our data demonstrate that AAS in doses believed to occur in steroid abusers can induce significant modulation of GABAergic transmission in brain regions essential for neuroendocrine function. In addition, the effects of these steroids can vary significantly between brain regions in a manner that appears to depend on the subunit composition of GABA(A) receptors expressed.

http://www.ncbi.nlm.nih.gov/pubmed/10848550
 
The effect Hormones specifically sex hormones Estrogen and Testosterone among others have on the brain as a whole is not completely understood. This comes up a lot in the field of sexuality, Transgendered psychology specifically. A quick glance through the AMA literature on depression on pre-hormone treated transgendered individuals shows that there is a marked increase in depression, while their hormone treated counterparts suffer from far less instances of depression related specifically to self image. Another example is hormone therapy in men suffering from Andropause induced depression, and the resolution of the depression upon treatment with Testosterone. So they do effect the brain, and in ways we are not completely aware of. Though I would love to see a study on Testosterone and its effect of consciousness as to what exactly the impact is. It has with out a doubt shaped the male zeitgeist through out the ages and is a fundamental corner stone of the male experience. The fact is just that layer of consciousness as pertaining to sexuality is complex enough, with out dragging the whole of consciousness into the subject, because frankly we understand more about the complex workings of quantum mechanics then we do about the nature of consciousness. As any body that as taken psychedelics, can tell you consciousness is very malleable, elusive, and fragile. Add to that the complexities of the brain, and the rest of the human machine it is a wonder we know what we know, because really we are playing with the children's instruction book and what we do is fucking magic to doctors 100 years ago, and will be cheap tricks compared to what we will be doing in another 100 years. It astounds me just how complex of an organism we are. But I digress. Give the sites at the bottom a read they are interesting.

~The testosterone-derived neurosteroid androstanediol is a positive allosteric modulator of GABAA receptors.
http://www.ncbi.nlm.nih.gov/pubmed/20551294

~ Testosterone Enhances GABA and Taurine but not N-Methyl-D,L-Aspartate Stimulation of Gonadotropin Secretion in the Goldfish: Possible Sex Steroid Feedback Mechanisms
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2826.1993.tb00372.x/abstract

~Testosterone Rapidly Reduces Anxiety in Male House Mice (Mus musculus)
http://www.sciencedirect.com/science/article/pii/S0018506X02918386

~Anxiolytic-like actions of testosterone in the burying behavior test: role of androgen and GABA-benzodiazepine receptors
http://www.sciencedirect.com/science/article/pii/S0306453005000521

So yeah there is some action there with androgens and the GABA sites among others.
 
Interactions with gaba receptors could play into how cortisol is released while on and when entering pct correct? Similar to as why when coming off benzos or the drink that we feel anxious, depressed, etc.
 
Yeah there is a similar effect there. The depression as well that has been documented with long term abuse of Anabolics. Take a look at William Thomas "Bill" Romanowski in his bio he admitted that his reckless abuse led to depression. This has been documented in other books and papers, and you can see it in certain compounds that are known for anxiety and the like. So there has to be more to it then some GABA interactions, But I am nit fully abreast of the situation. Though I have started a little bit of a more in depth research what with the talk of moderator I figure I should brush up, and really research so I can be a little more effective. That and I am having a bit of the stress insomnia with the up coming engagement, I know my woman will say yes but it is still a little nerve racking waiting for the moment I am going to need a vacation for the vacation.
 
testosterone is a powerfull hormone, directly affecting metabolism, protein synthesis and most importantly directly controls gene transcription, expretion and repression through activation of the androgen receptor. This steroid, like most sex steroids, certainly binds to receptors in the brain, but like in the body it actives androgen receptors in neurons. Androgen receptors are not cell surface receptors like the targets of most psychoactive drugs. Rather they are nuclear receptors affecting DNA transcription. This means, that the affects may be delayed slightly but uforia can deffinitly be an affect of testosterone therapy. However this rare, and it is more likely in your case, that due to low testerone levels throught your life, you haven't felt as good as you should and may even suffered very mild non significant depression. As soon as you reintroduce testosterone, you regain full brain and body function, leading to a perceived uforia.
However, you should never abuse steroids, no matter how good they feel. In my opinion, its better to abuse opioids than steroid hormones, due to studies showing that high doses of testosterone and other anabolic steroids lead to instent death of neurons. This may explains why heavy steroid abusers can develop psychotic disorders with symptoms worse thas psychitsophrenia.
This doesn't mean don't use them atall, just use as directed by your doctor, at the lowest possible and affective dose and only for as long as needed.
 
The anxiolytic and antidepressant affects of testosterone may actualy be due to neuroactive steroids, which are metabolits of testosterone synthesised in the CNS by particular enzymes. Neuroactive steroids are amazing compounds showing a wide range of benefits: anti depressant, antioxidant, neuroprotective, neurotrophic, antiapototic and anti excitotoxic effects. In addition in animals, neuroactive steroids such as alapregnanalone didn't produce any tolerance to CNS depression even at high doses given over long periods of time. The same goes for isolate human neuroblastoma cell lines and embryonic neuronal cell lines.
 
On a side note as much as I can't tolerate it which I regret because I love how it makes me feel, anadrol makes me feel sort of high a bit it makes me feel maybe euphoric slightly with some sort of strange pleasurable aggression, akin to the feeling a few minutes after you cum. I'm not joking I actually feel different on anadrol constantly, feel like a god.
 
Neuroprotection said:
testosterone is a powerfull hormone, directly affecting metabolism, protein synthesis and most importantly directly controls gene transcription, expretion and repression through activation of the androgen receptor. This steroid, like most sex steroids, certainly binds to receptors in the brain, but like in the body it actives androgen receptors in neurons. Androgen receptors are not cell surface receptors like the targets of most psychoactive drugs. Rather they are nuclear receptors affecting DNA transcription. This means, that the affects may be delayed slightly but uforia can deffinitly be an affect of testosterone therapy. However this rare, and it is more likely in your case, that due to low testerone levels throught your life, you haven't felt as good as you should and may even suffered very mild non significant depression. As soon as you reintroduce testosterone, you regain full brain and body function, leading to a perceived uforia.
However, you should never abuse steroids, no matter how good they feel. In my opinion, its better to abuse opioids than steroid hormones, due to studies showing that high doses of testosterone and other anabolic steroids lead to instent death of neurons. This may explains why heavy steroid abusers can develop psychotic disorders with symptoms worse thas psychitsophrenia.
This doesn't mean don't use them atall, just use as directed by your doctor, at the lowest possible and affective dose and only for as long as needed.
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Would you like to present evidence to back up your statement..!!
 
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I'm pretty sure every od on heroin I ever had knocked a few brain cells out from lack of o2. Lol. It's really not a laughing matter but I honestly feel my gear usage is a lot healthier than me being an H junkie
 
I'm a chronic, heavy methamphetamine user, but if anabolic steroids make you look like those body builders in muscle magazines, sorry but I'll stick with speed for now.
 
Dresden said:
I'm a chronic, heavy methamphetamine user, but if anabolic steroids make you look like those body builders in muscle magazines, sorry but I'll stick with speed for now.
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Well at least you're honest!
 
I actually have seen a study before where rats that were given testosterone during opioid WD showed less symptoms than rats that weren't. Now I don't know how often the study was repeated, the controls, etc. and why; but some people did seem to interpret it as testosterone possibly potentiating opioids or ones own endorphins. I personally don't think it would be noticable under normal circumstances and have used opioids while on test and didn't notice anything much in terms of potentiating or a difference in tolerance.

While I don't think the steroids causing aggression is 100% a myth I do think the "roid rage" thing is completely misinterpreted. Test doesn't effect the ability of your frontal lobe to control violent impulses the way say, alcohol, might. So I think someone with a problem with violence already may have problems, but someone who doesn't I've never seen it happen. Almost like what you define as acceptable aggressive behavior (or acceptable to some degree) might increase but I don't think they (androgens) will make you do something you normally would never do.
 
This comment right here is spot on ^^ the reason I think it would help with recovering addicts is because they would have a very low natural testosterone production which would lead to further depression, fatigue and low libido and energy in general. While I agree with test not causing roid rage or increases in anger, it can't be said the same with other steroids in my experience.
I've had test, tren, Deca, dbol, mast, superdrol and eq for a few weeks which never affected my mood in any other way than being positive apart from superdrol which made me very lethargic.
The same can't be said for anadrol, it made me much more aggressive, I wouldn't call it roid rage, not even an increase in anger. It caused me to think differently, I was walking into rooms and scanning the room sizing people up for some reason. I was in asda/Walmart taking a dump one day (anadrol makes me shit like fuck to the point I can't take it at all as I just shit all my food out), and some guys started shaking the stall and shouting in trying to act the big men, normally I would laugh, but this time I busted out of the stall and lifted someone off the feet by their throat. And I felt good about it after I really enjoyed it.
Only happens on oxys though nothing else including tren at 500mg+ and it was a one off, I controlled it every other time.
 
Genetic Freak said:
Oh Really:

anbolic steroids induce region- and subunit-specific rapid modulation of GABA(A) receptor-mediated currents in the rat forebrain.
Jorge-Rivera JC, McIntyre KL, Henderson LP.
Department of Physiology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA.
• J Neurophysiol. 2007 Sep;98(3):1841.

Our data demonstrate that AAS in doses believed to occur in steroid abusers can induce significant modulation of GABAergic transmission in brain regions essential for neuroendocrine function. In addition, the effects of these steroids can vary significantly between brain regions in a manner that appears to depend on the subunit composition of GABA(A) receptors expressed.

http://www.ncbi.nlm.nih.gov/pubmed/10848550
Click to expand...

Any ideas on how this affects people with a history of benzo abuse? For instance would this affect someone's recovery period while kicking benzos, or relevant to me, would AAS use (especially test in bodybuilding doses) directly cause a flare up in withdrawal symptoms... possibly even send someone back into withdrawal if they have already gone through the entirety of withdrawal but are still very susceptible to the rebound effects of GABAA drugs like zolpidem or heavy doses of alcohol?

Even though It's been a while since I went through benzo withdrawal, even average doses of a benzo will cause rebound effects, with the intensity and duration of this rebound increasing with surprisingly little use. For this reason I avoid GABAA drugs like the plague but since this is the first time I've heard of test modulating GABAA I can't help but be intrigued on how this affects people who have or are quitting a benzo habit. Unless steroid induced GABAA modulation is entirely different and unrelated to benzodiazapine's activity as positive allosteric modulators?
 
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I have no information to back any of this up other then personal experience
But being on girl helped curb withdrawls from various forms of drug abuse during my life

It helped with a few friends also who dabbled with benzos
 
《Plasticity》;13394887 said:
Any ideas on how this affects people with a history of benzo abuse? For instance would this affect someone's recovery period while kicking benzos, or relevant to me, would AAS use (especially test in bodybuilding doses) directly cause a flare up in withdrawal symptoms... possibly even send someone back into withdrawal if they have already gone through the entirety of withdrawal but are still very susceptible to the rebound effects of GABAA drugs like zolpidem or heavy doses of alcohol?

Even though It's been a while since I went through benzo withdrawal, even average doses of a benzo will cause rebound effects, with the intensity and duration of this rebound increasing with surprisingly little use. For this reason I avoid GABAA drugs like the plague but since this is the first time I've heard of test modulating GABAA I can't help but be intrigued on how this affects people who have or are quitting a benzo habit. Unless steroid induced GABAA modulation is entirely different and unrelated to benzodiazapine's activity as positive allosteric modulators?
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I'm not entirely certain, but testosterone's neuroprotective/neuroregenerative attributes also involve GABA related activity.
 
I'm just wondering if there is any cross-tolerance or similar activity at GABAA, being that benzos are positive allosteric modulators at that site and test is apparently a "modulator"... and if anyone with a better grasp on pharmacology can elaborate on whether these modes of action are similar or completely unrelated.

My instinct is to say the two (benzos and test) are not cross-tolerant at all being that there's obviously no benzo like effects noted for gear, and long term use doesn't lead to benzo withdrawal. However it's always good to play it safe and ask.

I've already got 2 vials of test, arimidex, clomid, and nolva so a cycle is inevitable, though I won't start it for a while. I just want to know if my history of benzo withdrawal is gonna bite me in the ass mid to post cycle. I highly doubt it will, but I guess I'll find out when I start my cycle.
 
《Plasticity》;13399104 said:
I'm just wondering if there is any cross-tolerance or similar activity at GABAA, being that benzos are positive allosteric modulators at that site and test is apparently a "modulator"... and if anyone with a better grasp on pharmacology can elaborate on whether these modes of action are similar or completely unrelated.

My instinct is to say the two (benzos and test) are not cross-tolerant at all being that there's obviously no benzo like effects noted for gear, and long term use doesn't lead to benzo withdrawal. However it's always good to play it safe and ask.

I've already got 2 vials of test, arimidex, clomid, and nolva so a cycle is inevitable, though I won't start it for a while. I just want to know if my history of benzo withdrawal is gonna bite me in the ass mid to post cycle. I highly doubt it will, but I guess I'll find out when I start my cycle.
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i doubt it
during my drug dealing days I was able to help people shake their problem(i know thats an oxymoron)if the really wanted to make a change

A lot of drug addicts rationalize their addiction by enjoying taking gear ive found that to be pretty successful
Ive known people to have the same concerns i wasnt able to ever give a firm answer, but they never said anything to me about it or asked me how to deal with any weird symptoms before during or after cycle
 
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