Does smoking weed render your endocannabinoids useless?

[Nooo]

Because of how desensitized your cannabinoid receptors are.

 

[xx001]

We don't entirely know. Downregulation happens but there is not enough research on the endocannabinoid system to say for sure. Heck, we aren't even totally sure of the long term effects of antidepressants downregulating serotonin receptors.

Some people go through a mild withdrawal after stopping heavy use of weed, so there is something going on there.

 

[AlphaMethylPhenyl]

If they were 'useless' you'd be dead. Down-regulation is the reality, leading to increased stress/boredom/depression.