does opiate potentiation increase tolerance

[Stop today stopnow]

does opiate potentiation increase tolerance

Can opiate potentiation help you achive a lower daily dose by needing to take less to get through the day which will lower your tolerance and make withdrawals easier if your trying to taper down?

 

[alasdairm]

support -> bdd.

alasdair

 

[blight12]

Most potentiators work by increasing the delivery or availability of the primary substance to the receptors which is theoretically equivalent to a higher dose in terms of tolerance.

I cant think offhand of a potentiatior that works differently to this concept besides perhaps those few that work to reduce or limit tolerance such as NMDA drugs etc. If there are others I would be interested.

 

[thesameoldfears]

^ I agree with this. An actual potentiater actually increases the amount of drug your body is able to process so I believe your tolerance would increase along with it.

Something that just synergizes and makes you "feel" more high without actually increasing the amount of drug metabolized would not increase your tolerance to my knowledge.

 

[Oxide]

In my experience, opiate potentiation is a path of disappointment.

In theory, yeah, everything you mentioned should take place. In practice, however, it sounds better than it actually works.

As you learn more about it; enzymes, how your body metabolizes things, etc. you sort of "psyche" yourself up into thinking you've found some sort of holy grail. As it turns out though, you'll probably notice little to no improvement in terms of how high you feel and for how long you feel high. At least, that's how it turned out for me. Anecdotal evidence at best, I know.

Cimetidine and grapefruit juice, tums, all of those things. As highly touted as they are as a tool of the addict, they just don't live up to the hype in terms of effectiveness.

Far be it from me to advocate the dangers of poly-drug use, but adding other drugs is the only solution to the "less is more" myth of opiate potentiation.

 

[blight12]

^ Yeah. However pursuing something like opiate tolerance reduction for noble purposes perhaps in the line of using Iboga and so forth might provide the magical results you might be looking for. This path requires absolute respect and caution however. You are warned.

 

[Cave man 1234]

This is stop today stop now thanks alot guys for your help

i will continue to taper down without potentiators

im currently on around 5 a day give or take 1 from a 15 a day 5 year habit.

Soon to be ex habit.

 

[Cave man 1234]

Iv been using tagamat the last two weeks thinking it will help lower my dose

But realised i need to take more if i dont use the tagamat

I wish i would of known this before and never start potentiating

Though it did help lenghten the time period before i needed the next dose

I need to taper down without tagamat till i reach about 30 mg a day and stop

 

[pasha]

Most potentiators work by increasing the delivery or availability of the primary substance to the receptors which is theoretically equivalent to a higher dose in terms of tolerance.

In practice, this^ therefore potentiation equates to stronger potency through higher affinity.

However, I don't think the potentiation they provide is strong enough to cause a noticeable difference in withdrawals.

 

[tentram]

^ Yeah. However pursuing something like opiate tolerance reduction for noble purposes perhaps in the line of using Iboga and so forth might provide the magical results you might be looking for. This path requires absolute respect and caution however. You are warned.

Youre mistaken. Ibogaine us used to treat and cure addictions, not help you out with lowering your tolerance.

 

[Captain.Heroin]

I think it's going to depend a lot on what your opiate tolerance is, what drug you're utilizing the synergy of, dosages, unique effects that may or may not be a general trend among users or a person-by-person unique reaction...etc

For instance, if I take benzodiazepines and/or antihistamines to potentiate buprenorphine, I'm not going to notice buprenorphine tolerance growing.

If you use drinking alcohol in order to boost the effects of benzodiazepines, you bet your ass there'll be a tolerance increase.

If you're using tramadol/codeine/hydrocodone to potentiate oxycodone/morphine/oxymorphone/heroin/fentanyl, then yeah, tolerance is going to grow.

IME, if you're using cannabis to potentiate opiates, I don't think you're going to notice an actual tolerance to the opiates. You will likely be able to go back to not using cannabis with your opiates, and won't need a higher dosage.

If you're using methamphetamine to potentiate opiates (horrible fucking idea), it will raise your opiate tolerance. The reason being is that methamphetamine reduces the effects of all other recreational drugs either from a slight to heavy degree. For instance, if you're going to be using a point of heroin to get a mild buzz or nod (if you're still lucky and have low tolerance), just being on methamphetamine, will require you to use at least 2x as much opiates to attain the same opioid effects. The synergy will be there, especially due to how good you'll feel. However, it does lead to a raised tolerance.

The same goes for benzodiazepines and methamphetamine. Off methamphetamine, 1mg alprazolam is felt strongly. On (a mild dosage) of methamphetamine, 2mg of alprazolam might not even deliver 50% of the effects that just one 1mg alprazolam would without methamphetamine in the system.

One last example for a "person to person" type unique reaction... take psychedelics and opiates. I have done LSD + heroin several times. Some people really, really, really enjoy this combination. They claim it's the perfect way to balance out the stimulant-type effects of LSD as well as increasing visuals. However, other people feel the heroin dulls down the psychedelic visuals/feel to the trip. And yet other people may feel the heroin over powers the LSD, and other people might even say LSD would over power the effects of the heroin.

So all in all, opiate potentiation isn't exactly black and white; there's lots of unique outcomes here, so everyone, please be careful when consuming drugs.