ComfortablyNumb95
Bluelight Crew
because I read it all the time but I don't see a reason for it.
Harm Reduction Does mixing downers and uppers ACTUALLY stress your heart?
- Thread starter ComfortablyNumb95
- Start date
Are you looking for some articles or something?
It always made sense to me one drug is telling your heart to slow down and another is telling it to speed up at the same time so the heart finally gives out after all this abuse.
It always made sense to me one drug is telling your heart to slow down and another is telling it to speed up at the same time so the heart finally gives out after all this abuse.
Jackeh
Bluelighter
I thought the main damage was because you didn't actually notice.
For example - you're on a depressant such as heroin. You decide it'd be a good idea to take some speed for a bit more of a buzz. The speed cancels the effects of some of the heroin, so much so that you believe the heroin has worn off or isn't affecting you as much as it really is. So to regain the depressant high, you take more - not realising it is still taking effect.
Then it leads to overdose because of misjudgement of the subjective effects.
For example - you're on a depressant such as heroin. You decide it'd be a good idea to take some speed for a bit more of a buzz. The speed cancels the effects of some of the heroin, so much so that you believe the heroin has worn off or isn't affecting you as much as it really is. So to regain the depressant high, you take more - not realising it is still taking effect.
Then it leads to overdose because of misjudgement of the subjective effects.
ComfortablyNumb95
Bluelight Crew
yeah that'd be nice but if someone could simply explain it to me I'd be happy.
shouldn't the 2 different drugs counteract eachother? I genuinely don't know, I just wanna make sure it is/it isn't safe for future drug use.
shouldn't the 2 different drugs counteract eachother? I genuinely don't know, I just wanna make sure it is/it isn't safe for future drug use.
ComfortablyNumb95
Bluelight Crew
@ jackeh yes I thought the same thing.
This once was available .. but was discontinued
From Wikipedia
"Dexamyl (or Drinamyl in the UK) is the brand name of a combination drug composed of amobarbital (previously called amylbarbitone) and dextroamphetamine.[1]
First introduced in 1950 by Smith, Kline and French, Dexamyl was marketed as an antidepressant medication that did not cause agitation, and also as an anti-anxiety drug and diet drug. Amphetamine alone had previously been marketed as an antidepressant (under the Benzedrine Sulfate brand) beginning around 1938. The amphetamine in Dexamyl was intended to elevate mood, while the barbiturate was added to counter the side effects of the amphetamine. Its name is a portmanteau of dextroamphetamine and amylbarbitone.
The British Prime Minister Anthony Eden was prescribed dexamyl; he was using it to treat his abdominal pain. It has been suggested that the drug impaired his judgement during the Suez crisis. The failure of his Suez policies led to his ouster while he was recovering in Jamaica.
In Britain during the early 1960s, the drug was taken by "tired housewives", and was also abused by youths who took excessively large doses and nicknamed the triangular blue tablets "purple hearts". This became a celebrated part of the Mod subculture. The main character of the film of Quadrophenia by The Who is shown taking purple hearts at a party, then subsequently appearing to suffer an attack of amphetamine psychosis.[2]
In the late 1960s and early 1970s, Dexamyl spansules—a clear and green capsule containing green and white "beads"—became popular as a street-drug upper nicknamed "Christmas trees," a reference to its appearance.
The Bureau of Narcotics and Dangerous Drugs and the Food and Drug Administration decided to recall all diet drugs that contained amphetamines and required all of them to be off the market by June 30, 1973. Smith, Kline & French, the producer of Dexamyl and Eskatrol, was excepted from an order banning interstate shipment of its drugs. The company asked for a hearing before the F.D.A.[3]
Dr. George C. Nichopoulos was indicted in May 1980 for having improperly prescribed Dexamyl and Preludin to the singer Jerry Lee Lewis, despite knowing he was addicted to them.[4] Dr. Patrick A. Mazza, team physician for the Reading Phillies, said he prescribed Dexamyl, Eskatrol, Dexedrine, and Preludin for Steve Carlton, Larry Christenson, Tim McCarver, Pete Rose, Larry Bowa, and Greg Luzinski. The charges against Mazza were dropped after he contended that he had provided the prescriptions in good faith to the baseball players at their request.[5]
Dexamyl was discontinued in the 1970s in favor of MAO inhibitors and tricyclic antidepressants.
From Wikipedia
"Dexamyl (or Drinamyl in the UK) is the brand name of a combination drug composed of amobarbital (previously called amylbarbitone) and dextroamphetamine.[1]
First introduced in 1950 by Smith, Kline and French, Dexamyl was marketed as an antidepressant medication that did not cause agitation, and also as an anti-anxiety drug and diet drug. Amphetamine alone had previously been marketed as an antidepressant (under the Benzedrine Sulfate brand) beginning around 1938. The amphetamine in Dexamyl was intended to elevate mood, while the barbiturate was added to counter the side effects of the amphetamine. Its name is a portmanteau of dextroamphetamine and amylbarbitone.
The British Prime Minister Anthony Eden was prescribed dexamyl; he was using it to treat his abdominal pain. It has been suggested that the drug impaired his judgement during the Suez crisis. The failure of his Suez policies led to his ouster while he was recovering in Jamaica.
In Britain during the early 1960s, the drug was taken by "tired housewives", and was also abused by youths who took excessively large doses and nicknamed the triangular blue tablets "purple hearts". This became a celebrated part of the Mod subculture. The main character of the film of Quadrophenia by The Who is shown taking purple hearts at a party, then subsequently appearing to suffer an attack of amphetamine psychosis.[2]
In the late 1960s and early 1970s, Dexamyl spansules—a clear and green capsule containing green and white "beads"—became popular as a street-drug upper nicknamed "Christmas trees," a reference to its appearance.
The Bureau of Narcotics and Dangerous Drugs and the Food and Drug Administration decided to recall all diet drugs that contained amphetamines and required all of them to be off the market by June 30, 1973. Smith, Kline & French, the producer of Dexamyl and Eskatrol, was excepted from an order banning interstate shipment of its drugs. The company asked for a hearing before the F.D.A.[3]
Dr. George C. Nichopoulos was indicted in May 1980 for having improperly prescribed Dexamyl and Preludin to the singer Jerry Lee Lewis, despite knowing he was addicted to them.[4] Dr. Patrick A. Mazza, team physician for the Reading Phillies, said he prescribed Dexamyl, Eskatrol, Dexedrine, and Preludin for Steve Carlton, Larry Christenson, Tim McCarver, Pete Rose, Larry Bowa, and Greg Luzinski. The charges against Mazza were dropped after he contended that he had provided the prescriptions in good faith to the baseball players at their request.[5]
Dexamyl was discontinued in the 1970s in favor of MAO inhibitors and tricyclic antidepressants.
Crankinit
Bluelighter
- Joined
- Sep 17, 2007
- Messages
- 6,175
Basically what Jackeh said. The risk isn't that the two different drugs treat the heart like a tug-o-war rope, but that the effects of one class masks the effects of the other class, allowing you to take much more of both than you could normally manage, but then one wears off while the other doesn't and bam, you're in an overdose. The classic example being the speedball - someone shoots coke and heroin, the coke lasts a fraction of the duration the heroin does, so they shoot more to get the same rush, keep going till they run out, then the coke that was keeping them awake drains out of their system and they have several doses worth of heroin still active, pass out, coma, death.
Of course the same can happen the other way around - usually not as fatal as amphetamines don't cause respiratory depression (although if there are underlying cardiovascular problems, it could probably knock you off), but very, very unpleasant.
Of course the same can happen the other way around - usually not as fatal as amphetamines don't cause respiratory depression (although if there are underlying cardiovascular problems, it could probably knock you off), but very, very unpleasant.
pinpoint
Bluelighter
I'm Rx'd Dexedrine and although it is less anxiety-inducing than Adderall I still use it in conjunction with Etizolam since I find that it takes the edge off. Shrinks regularly Rx AHDH meds (uppers) & benzodiazepines (downers) together, not that this puts a rubber stamp of approval on anything since after all, shrinks aren't exactly known to be the most intelligent sector of the healthcare industry - even though they sure act like they are!
I do believe that mixing supratherapeutic doses of uppers and downers puts a strain on your cardio system, but the true danger lies in mixing a CNS depressant (re: opioids) with short acting stimulants (re: cocaine) as explained above - once the coke wears off your CNS goes night-night.
I do believe that mixing supratherapeutic doses of uppers and downers puts a strain on your cardio system, but the true danger lies in mixing a CNS depressant (re: opioids) with short acting stimulants (re: cocaine) as explained above - once the coke wears off your CNS goes night-night.
Here's one In our archives that explains a bit about lethal drug combos
http://www.bluelight.org/vb/threads/56672-Mixing-uppers-and-downers-whats-the-final-word
http://www.bluelight.org/vb/threads/56672-Mixing-uppers-and-downers-whats-the-final-word
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ComfortablyNumb95
Bluelight Crew
thanks guys, it's just that I hate it when people spread this "common knowledge" on the interwebz without knowing what they're talking about or making some research.
ComfortablyNumb95
Bluelight Crew
(taken from the thread trainspotter linked)
I'm confused now. is this true or are these guys talking outta their asses?
shouldn't one substance telling your heart to go faster and one telling it to go slower sorta cancel themselves out? I really see no danger in here (maybe i'm wrong)
or else why would you use a benzo (for example) to ease a stimulant OD if it only made it worse? (which sounds pretty ridicolous to me)
Jackeh
Bluelighter
I don't see how they can affect each other though. They should cancel, or one would take preference but I don't see how it would confuse the heart. The muscles can either contract or relax. It can't do both at the same time, so the heart shouldn't possibly be stressed out.
I don't think benzos really cancel out a stim overdose they will help yes that's all we really have in the way of options but if a person is dying from a heroin overdose giving then cocaine won't bring then out their chest is still in respiratory depression
ComfortablyNumb95
Bluelight Crew
I didn't mean the pleasurable effects I meant the effects on your heartrate.
^ ahah if only I had some
ComfortablyNumb95
Bluelight Crew
^ same thing I thought, as Jackeh said it either goes slow or fast.