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Does marijuana use release dopamine/ serotonin?

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Big)Sky

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I was just curious if marijuana released any of the feel good hormones along with stimulate the canabaniod receptors?
 
i posted some info that touches on this, speaking about it (cbd's) as a critical alternative to antipsychotic medications; a few posts down on the 2nd page in our cannawiki, in the BL wiki, its pretty interesting/scary stuff honestly...

generally, antipsychotics/neuroleptics work by inhibiting dopamine receptors, this can be counterproductive for some "psychotic" disorders, as our endocanabinoid system, if over, or underestimated can be pretty nasty...

im sure you can find many outstanding articles on the subject, but i dont believe that mj does have much interaction with many neuro-systems in our brain, besides specific thc/cbd receptors.
 
It does not directly stimulate DA/5HT release.

Release of DA may be indirectly effected, though, as lots of pleasurable things (sex, good food, drugs, etc) cause the body to release more dopamine through the natural mechanisms (vs releasers and reuptake inhibitors, which effect levels of neurotransmitters by acting on the transporter directly)
 
Everything I've read suggests it does not have a direct effect on 5-ht binding nor does it play a major role in the mesolimbic pathway.

In short - not really. It primarily takes effect only on your CB1 and CB2 receptors- located heavily near the hippocampus and in many of the areas lining that area of the brain, as well as oxygen deprivation depending on ROA.
 
no it does not shoot off serotonin but it does tickle if you will , the sert receptors making the receptor wiggle from side to side, producing this high we all love
 
Could explain why alot of cannabis users feel the burnout after smoking which leaves them unmotivated and what not
 
Marijuana doesn't produce serotonin. However, it does affect a substance in the brain called anandamide. Anandamide causes a soothing sensation in the body when it reacts with THC (tetrahydrocannabinol), the active substance in marijuana.

Marijuana use affects dopamine, a neurotransmitter involved in the brain's pleasure producing or reward mechanism, which helps explain its potential for dependency.

Hope this helps!
 
^anandamide doesn't react with THC. The THC molecule is similar in shape to anandamide so it is able to fit into anandamide receptors in the brain.
 
^ lol yeah . I don't think it affects it directly though.


However I do believe it affects dopamine.
Not alot , but over time and chronic use. (?) you start to feel the effects such as lazyness, anxiety and other cognitive problems .
 
Directly, no. Indirectly, yeah. Cannabis has an effect on a variety of receptors/neurotransmitters. It definitely has an effect on serotonin, dopamine, (nor)epinephrine, acetylcholine, gaba, glutamate, etc. It's incredibly complex, it doesn't really matter wether the effect is direct or indirect, the question in the first post doesn't specifiy that either. It's effect on serotonin via cb1 receptors is (probably) due to the inhibitory effects gaba has on the reuptake of serotonin (and dopamine), hence more serotonin flows freely.
 
lol has anyone else realized how many different answers there are to this one question ?


Does anyone (humans in general) actually for sure , 100% know ?

It doesnt seem like it .
 
If we can determine what other drugs do pharmalogically, one would assume the same princibles used in exploring other drugs could be applied to cannabis as well.

I think it's just the lack of anyone with the knowhow and brains to actually have the reason, time, motivation to delve into marijuanas mechanisms of action.

One must also take into account the nature of cannabinoids. THC is psychedelic and stimulating in nature. CBD is somewhat antipsychotic and more sedating in nature. The complex mixture of drugs in cannabis make its mechanism of action seriously complicated, where you dont just have say one drug like morphine exercising it's effects on the brain, but you have all these drugs from cannabis interacting and being influenced by each other as they effect the brain. One way to visualise this is to think what an IV dose of pure thc or pure cbd would feel like compared to smoking cannabis, alot different i'd bet my nuts on that.

Actually jamesmartin sorry mate you do propose a very true fact, but this is due to the complex mixture of drugs that induce the cannabis experience, and the fact that a number of these drugs are psychedelic compounds makes the true nature of weeds mechanism of action very very complex.

Just think, they cant work out exactly how LSD works yet, while we know it has a special relationship and action on the 5-HT receptors, we're far from claiming to understand how lsd works for that matter, the psychedelic experience is a seriously complicated process in the mind, the alteration of the minds natural awareness filter and other brain chemistry changes that are unique to psychedelic compounds.

So yeah i guess the point of my thread is to highlight how overly complex cannabis' whole mechanism of action is. Between it's subtle psychedelic qualities, it's antiemetic qualities, euphoric and soothing qualities and a whole lot more, it is a surprisingly complex drug in my opinion. Also what is weird is it's vast difference in effect between users who are new to cannabinoids and those who're very familiar with them, one could say they're too very different experiences, which would take more than just tolerance issues to explain.
 
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