Does ginseng block the effects of oxycodone?

[SpunkySkunk347]

I don't dare ask this question in any other subforum besides Advanced Drug Discussion, because I know I'll get all sorts of stupid answers.

Does ginseng block the effects of oxycodone?

I heard ginseng was an opiate antagonist; is this true? What opiate receptor subtype is it an antagonist of? How strong of an antagonist is it?

Approximately how long after taking a dose of, say, 50mg of ginseng would one be able to take a dose of 30mg oxycodone without the ginseng dulling any of the effects?

 

[sekio]

http://www.bluelight.ru/vb/showthread.php?t=473026

It doesn't sound like it's a mu antagonist at all. Try it and see.

The closest thing I can dredge up with a quick google search is that ginseng saponin extracts will counteract the painkilling properties of selective kappa agonists through a serotonin-dependent mechanism. It doesn't appear that ginseng is a mu/delta antagonist to any sort of extent.
Pharmacol Biochem Behav. 1992 Aug;42(4):587-93.

 

[atara]

I heard ginseng was an opiate antagonist; is this true?

Where did you hear this?

Ginseng itself is just a plant; some of the alkaloids therein might have mu-antagonizing effects, but I doubt that ginseng tea would have become popular if such alkaloids were present in large enough amounts to matter.

 

[negrogesic]

No, any effect would be in theory subclinical and "perceptual".....Not to discount your observatations but this should not inactct measureabl.....aoundsa the dreaded t word....for oxycodone its rather notorious.

 

[DJHENRU]

Ive combined them to find actually, I thought; through length potentiation akin to grapefruit it was actually potentiated somewhat but different.
Did not use oxycodone but lemony poppy seed tea.

 

[SpunkySkunk347]

I have now tried both panax ginseng and oxycodone at the same time while noticing no significant dulling in the effects of the oxycodone.

If there were any dulling of oxycodone's effects, it would have only been perceptual (as someone else already mentioned in this thread).

Thanks for the responses

 

[ThelemicMage]

I must post a quick reply about my experience with pod and ginseng. Decent amount of pod, a few pills of 100mg panax ginseng(korean) extract. The increased heart-rate, along with a little sweating, might make one think ginseng is making them lose their dopiness. I am also using cocaine throughout days and nights, with no adulterants. Don't ask. The coke, when on a very low fix of opiates, makes one feel better at very low doses, but withdrawal at higher doses, due to the norepinepherine/seratonin reuptake blocking qualities as compared to its dopamine-reupdake blocking qualities.

I enjoy all three of them.

Do what thou Wilt shall be the Whole of the Law
Love is the Law, Love under Will

 

[cryptix420]

I've never heard of a relationship between ginseng and opiates. I have however heard about it in relation to stimulants. It does something to your dopamine/adrenaline that counteracts the effects of amphetamine and the like..or so I think. I like to take little vials of ginseng when coming down from any stim to recharge my adrenals, even with LSD.

 

[Bucklecroft Rudy]

Opiates lower adrenaline by directly controlling adrenal centers in the brain. This is an essential part of their action. Anything which raises adrenaline will perceptuallly take away from an opiate buzz. Likewise opiates blunt stimulant edges.