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Does either Meth-AMT or Methylenedioxy-AMT (MD-AMT) exist, or possible to synthesize?

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FractalDragon

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Aug 2, 2013
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So as we all know, AMT (alpha-methyltryptamine) is basically the tryptamine version of amphetamine. If amphetamine were abbreviated into three letters like with AMT, it would be AMP (alpha-methylphenethylamine).

With amphetamine (alpha-methyl-phenethylamine) we can add another methyl group and the result would be methamphetamine. Has Shulgin or any other chemist ever tried doing the same with AMT? It would seem like an obvious experiment to do after trying and succeeding in adding an alpha-methyl group to tryptamine. Adding another methyl group to AMT would make the tryptamine equivalent of Meth-AMP; which is Meth-AMT. This can also be called methamtryptamine. However, Shulgin didn't seem to experiment as much with tweaking the AMT molecule. The main variation everyone knows about is 5-meo-amt...and we all know what that does.

Taking this logic further, we would be able take the Meth-AMT and add a 3,4-methylenedioxy-N to the Meth-AMT we would have MD-AMT (methylenedioxy-meth-AMT), the exact tryptamine version of what MDMA is to phenethylamine. Or we can just use the AMT molecule and add the methylenedioxy to it, making the tryptamine equivalent of what MDA is to phenethylamine. I think you all can see where I'm going with this. ;)

So has any chemist try to synthesize these? If so were they psychoactive? If these tweaks of these molecules haven't been done yet, why do you think that is? If these versions of AMT haven't been created yet, is it possible to make them? I imagine if it were possible to make and if they were psychoactive, they would have some very unique effects! What do you think?
 
Sounds EXTREMELY intriguing. Out of all the speculation I've seen on new chemicals, these sound like they could be amazing, if they worked to the laymans ideas of how these affect PEA
 
hypnagogic said:
Google leads to an earlier discussion of the same topic here: http://www.bluelight.ru/vb/threads/484924-5-6-or-6-7-methylenedioxy-alpha-methyltryptamine

The responses there don't make it seem too promising, unfortunately.
Click to expand...

I think N-Me-AMT is in TIHKAL. It is not an active psychedelic but has MAOI properties.

http://www.sciencedirect.com/science/article/pii/0006295262902319

Not sure if the other has been described but I am pretty sure it has at least been made.
 
4,5-MDO-tryptamines are known but not really more interesting than plain 4-HO/5-MeO, IMO.

And as above, N-me-AMT is known, but not anything to write home about. Tryptamine SAR is much different from PEA SAR.
 
Yah even though there is almost nothing about Meth-AMT that can be found, there is definitely slightly more on it than MD-AMT; couldn't find any info on the methylenedioxy version of it. With that said though, I really wonder whether Meth-AMT was abandoned too early. Perhaps if tested at higher doses there would have been something interesting.

Now with MD-AMT, whether it has been yet synthesized or not....it certainly hasn't been tested yet. Considering the way MDMA affects serotonin, I wonder whether the tryptamine version of it (MD-AMT) would have more of an effect on serotonin considering that AMT and its analogues are tryptamines, like serotonin. The tryptamine aspect combined with the chemical similarity to MDMA mean that perhaps MD-AMT might be a uniquely powerful empathogen-entactogen psychedelic euphoriant of its type. Or maybe not, maybe it has a weak action or no action at all. The only way to find out is to create and test it.
 
I have absolutely no background in chemistry so this is just a shot in the dark, but amphetamines including methamphetamine and MDMA get their effect mainly from serotonin/dopamine/norepinephrine release opposed to agonization.
AMT as far as I understand works on serotonin agonization as well as hormone release.
I would guess that adding the methyl group or anything further would only act to negate the actions of both drugs, rendering its serotoninogenic binding ability to neglible amounts if at all, and doing the same with its ability to release serotonin and dopamine etc.
Again just my 2 cents, I have no evidence to back any of this up

AMT itself is fairly neat in its ability to act in such a balanced fashion as a non selective agonist as well as a released, this leads me to believe that this is rare among psychedelics, the only other I can think of off the top of my head is MDA
 
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