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  • BDD Moderators: Keif’ Richards

Opioids Does clonidine potentiate morphine?

Potentiation in the way that we use the term around here means something specific. Usually, we are talking about using one substance concurrently with another in such a way that the former substance interacts in such a way as to actually boost the potency/effects of the latter.

Using Cocaine together with Alcohol creates a third, separate substance in the body known as Cocaethylenene which is more potent a substance than the other two. It would be appropriate to say that Alcohol potentiates Cocaine and vice versa.

Cannabis will not potentiate Alcohol. Both substances have sedative effects that can lead to greater perceived levels of intoxication. However, you're just experiencing Cannabis and Alcohol simultaneously. They do not happen to interact with each other in this symbiotic way described above.

Likewise, Clonidine is not going to potentiate Morphine. Clonidine is known to lower blood pressure and to a lesser extent, pulse. These effects typically lead to relaxation/sedation. If you take Clonidine with Morphine, you'll be more likely to become sedated, but it's not actually going to make the Morphine "better" or stronger in any way. The combination is not going to lead to a greater relief from withdrawal, for instance.
 
Keif' Richards said:
Potentiation in the way that we use the term around here means something specific. Usually, we are talking about using one substance concurrently with another in such a way that the former substance interacts in such a way as to actually boost the potency/effects of the latter.

Using Cocaine together with Alcohol creates a third, separate substance in the body known as Cocaethylenene which is more potent a substance than the other two. It would be appropriate to say that Alcohol potentiates Cocaine and vice versa.

Cannabis will not potentiate Alcohol. Both substances have sedative effects that can lead to greater perceived levels of intoxication. However, you're just experiencing Cannabis and Alcohol simultaneously. They do not happen to interact with each other in this symbiotic way described above.

Likewise, Clonidine is not going to potentiate Morphine. Clonidine is known to lower blood pressure and to a lesser extent, pulse. These effects typically lead to relaxation/sedation. If you take Clonidine with Morphine, you'll be more likely to become sedated, but it's not actually going to make the Morphine "better" or stronger in any way. The combination is not going to lead to a greater relief from withdrawal, for instance.
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Is there any actual real potentiaton effects for benzos or is just adding more sedation on too?
 
@Cuncefuct

Yes it could be said that there is real potentiation between Opioids and Benzodiazepines. Opioids and Benzodiazepines tend to synergize when taken together, meaning that the intoxication is often greater than the sum of the parts in the combination. Think, 2+2 should equal 4 but sometimes is actually equal to 6, 7 or 8.
 
paranoid android said:
I once injected clonidine and morphine and the shit took my breath away. Fuck clonidne i dont like that shit really
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I don't know that anybody really "likes" Clonidine. Lol. It's a utilitarian must-have addition for any good junky's toolbox though. I like to bill Clonidine as the true "no strings attached sedative". It is highly versatile and the only issue lies in not stopping it abruptly (following chronic, consistent administration" or taking so much that you poison yourself.
 
Keif' Richards said:
I don't know that anybody really "likes" Clonidine. Lol. It's a utilitarian must-have addition for any good junky's toolbox though. I like to bill Clonidine as the true "no strings attached sedative". It is highly versatile and the only issue lies in not stopping it abruptly (following chronic, consistent administration" or taking so much that you poison yourself.
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My ex loved slamming clonidine with opiates. Personally i thought it was abit much i mean iv its fucked
 
Clonidine absolutely potentiates opioids.

It's just not necessarily going to make the opioid experience more euphoric.

I've used clonidine & tizanadine many times for this exact purpose.

Why do you think dealers cut street fentanyl with xylazine (a drug related to clonidine, but less potent)...

Google "Clonidine Analgesia" or "Clonidine & Opioids" and you'll find all kinds of info about this sort of thing.
In fact clonidine is part of a lot of a opioid withdrawal protocols.

More from google -

Mechanism of clonidine analgesia

Clonidine produces its analgesic effects through several mechanisms, particularly at the spinal and supraspinal levels:

  • Activation of spinal alpha-2 receptors: In the dorsal horn of the spinal cord, clonidine activates alpha-2 receptors, which decreases the release of pain-signaling neurotransmitters, such as substance P, from nerve fibers. This reduces the transmission of pain signals to the brain.
  • Descending pain inhibition: It enhances the descending noradrenergic pathways that modulate pain, increasing the brain's own inhibitory control over pain signals.
  • Modulation of other systems: Clonidine also acts on the cholinergic, purinergic, and serotonergic pain systems, which contributes to its overall analgesic effect.
  • Blockade of nerve conduction: In peripheral nerve blocks, clonidine can block the conduction of C and A-delta nerve fibers, which transmit pain signals.
  • Synergistic effect with opioids: When used with opioids, clonidine and opioids can have a synergistic effect, providing greater pain relief together than either medication alone. This allows for lower doses of opioids, reducing opioid-related side effects.

Don't expect anything remarkable or "fun", but if you're in need of more sedation and some slight extra pain relief (totally dependent on the person & type of pain), then yes clonidine can help. But be warned, getting dependent on clonidine means you will have dangerous rebound high blood pressure when you stop.
 
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Hell yeah Clonidine makes opioids better. It is what they add to cancer patients when opioids are not cutting the mustard.

I use Clonidine 0.9mg daily for pain management with Roxi and Methadone. Everyone in pain management treasures their Clonidine.

Clonidine makes any drug better. I think people that are looking for some great "heady experience" tend to not agree with Clonidine.
 
DeathIndustrial88 said:
Why do you think dealers cut street fentanyl with xylazine (a drug related to clonidine, but less potent)...
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True but they are using Xylazine concentrate 300mg/1-5mL on the fetty. Makes it strong as hell.

Clonidine in 300mg/1-5mL would have killed all of Philly the first time they IV it.

PO 24 mg of xylazine equals Clonidine 0.6mg. Meaning I take 36mg of Xylazine a day at Clonidine 0.9mg daily.

IV xylazine has both a rapid distribution (t1/2α slightly lower than clonidine) and clearance (t1/2β much lower than clonidine), this translates to IV xylazine having a much harder "hit" than IV clonidine which makes it a suitable adulterant for illicit opioids.

Xylazine is dosed IV as 0.5mg/20lbs.
 
Keif' Richards said:
Potentiation in the way that we use the term around here means something specific. Usually, we are talking about using one substance concurrently with another in such a way that the former substance interacts in such a way as to actually boost the potency/effects of the latter.

Using Cocaine together with Alcohol creates a third, separate substance in the body known as Cocaethylenene which is more potent a substance than the other two. It would be appropriate to say that Alcohol potentiates Cocaine and vice versa.

Cannabis will not potentiate Alcohol. Both substances have sedative effects that can lead to greater perceived levels of intoxication. However, you're just experiencing Cannabis and Alcohol simultaneously. They do not happen to interact with each other in this symbiotic way described above.

Likewise, Clonidine is not going to potentiate Morphine. Clonidine is known to lower blood pressure and to a lesser extent, pulse. These effects typically lead to relaxation/sedation. If you take Clonidine with Morphine, you'll be more likely to become sedated, but it's not actually going to make the Morphine "better" or stronger in any way. The combination is not going to lead to a greater relief from withdrawal, for instance.
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To the Original question ^ That is the best answer.

Xylazine is similar to clonidine in some way? I thought two different categories of drug?

--- Please give me the clonidine!
 
notsmokeymcpot42088 said:
Xylazine is similar to clonidine in some way? I thought two different categories of drug?
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Clonidine and xylazine are
both alpha-2 adrenergic agonists

Xylazine is a structural analog of clonidine and an α2-adrenergic receptor agonist
en.wikipedia.org

Xylazine - Wikipedia

en.wikipedia.org en.wikipedia.org

So if dealers are using xylazine as a way to potentiate fent (which seems insane since fent is already incredibly potent itself), then there would obviously be some slight potentiation with clonidine. Especially with clonidine being more potent. It's commonly recognized that clonidine can help potentiate opioids & pain relief, so I'm not sure why there are some people in this thread who think it can't. People can easily google "clonidine & opioids" themselves & find a million articles about adding clonidine to enhance analgesia in patients using opioids. Not that this will translate to everyone getting potentiation from it due to individual factors. But it's important as a harm reduction forum to recognize that clonidine does in fact potentiate some of the effects (mainly the sedation & heart rate) of opioids. Which can become dangerous if one does too much of both.

I've used clonidine myself with buprenorphine a million times. Along with tizanidine. Does it give you more of an "opioid" effect? Meh, not really, but there's a slight relaxed & released feeling & even a dreamy drowsiness that can come along with it. It's more of a synergy, which can still be a form of potentiation.

It's not good to be messing with meds that lower your blood pressure if you don't need them though. It can be dangerous. And the fact that it can be dangerous combining the two should be enough of a fact alone to show that alpha-2-adrenergic agonists can potentiate opioids to the point of possible OD or death. So people should urge caution when using alpha-2 adrenergic drugs. There's also the rebound high blood pressure upon abruptly stopping them, that one needs to watch out for as well.

Them Witches said:
IV xylazine has both a rapid distribution (t1/2α slightly lower than clonidine) and clearance (t1/2β much lower than clonidine), this translates to IV xylazine having a much harder "hit" than IV clonidine which makes it a suitable adulterant for illicit opioids.
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This makes the most sense. Sounds awful though. I'm usually not one who likes to muck up my opioid highs by adding anything else sedating (well I use to not be anyway, but that changed over the last few years lol), so I can't imagine how much this shit could knock, you out. Fentanyl itself was pretty damn strong the first time I tried it in 2017/2018. Never used it again because that shit had me feeling like I was just gonna pass out & die & heroin/other opioids have never made me feel like I was in danger like that. I was lucky I didn't have any benzos or anything else in my system at the time.
 
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Thank you for that info death industrial and Dr. morphine

I always wondered WHY ON GODS GREEN EARTH XYLAZINE not in INACTIVE --- and now I know. (Reading rainbow noise)

True shame that the streets have no demand for real H. I hear the darknet does if you are hellbent. -- No I don't know anyone save the message
 
notsmokeymcpot42088 said:
True shame that the streets have no demand for real H. I hear the darknet does if you are hellbent. -- No I don't know anyone save the message
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Yeah fuck fentanyl & xylazine. I feel sorry for the addicts who are getting hooked now a days on that crap, who never got the experience the pure joy & amazing feeling of good heroin.
Heroin was beautiful. Fentanyl feels soulless & completely different to me.

But yeah, the first thing they did when I got into opioid WD treatment was put me on bupe & 3 different blood pressure meds to take care of the withdrawal & make the bupe a little stronger.

I've been using opioids for so long now that I've tried a lot of things for potentiation at this point. Everything from grapefruit juice, cimetidine, to benzos, ephedrine, stimulants, clonidine, tizanidine, muscle relaxers, cannabis, etc..

Light doses of stimulants are pretty good at potentiating the effects of opioids. So much so, that they once use to market opioid/stimulant combo drugs. I don't think they do anymore now a days though. Mostly the dopamine or norepinephrine releasing stimulants though. The reuptake inhibitors (except for cocaine) always seem to dull the opioid experience a bit or take over & cancel out the opioid effect altogether, but this could just be with my personal biology, since opioid/DRI combo drugs were a thing in the past. But I prefer the releasers, as the dual dopamine release feels much better than reuptake inhibition. Taking an opioid with things like ritalin or welbutrin seem to dull the opioid euphoria to me. Where as amphetamines enhance it.
 
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Shit almost killed me -- I didn't quite need narcan but I was down and bluelipped (I hear) ..... Luckily that and it almost happening a second time was enough for me to get that "This is not H" and I am out!

What am I suppose to do 2mg of a pack at a time never get a rush poke a hundred holes in my arm for a cold short fent buzz. NO just say NO to fake heroin!
 
I can't stand Clonidine either and Keithy said it best. I've only used clonidine when there was nothing else to ease withdrawal. Never to enhance the effects of other drugs or on its own recreationally. It just made me dizzy and sleepy because it lowers your blood pressure, but fuck it has helped me sleep when I thought it was impossible. It doesn't cover all the withdrawal symptoms, and I still take other compounds to ease the pain, but please, ALWAYS check for interactions first. My suboxone doctor was the one who prescribed me clonidine for opioid withdrawal specifically (symptoms the bupe didn't cover, but it also helps with full on withdrawal) They usually prescribe that before they resort to stronger meds like Baclofen, Gabapentin, Pregabalin or even Clonazepam & other benzo's. I've also heard of clonidine being as an atypical secondary anxiolytic. The lowering of the blood pressure combats the increased blood pressure brought on by anxiety or panic attacks, but other than that it doesn't behave like more common anxiolytics. It's usually used in this way for people who can't take benzo's due to health reasons (like in elderly) or if the person's likelihood to abuse benzo's is high. I view clonidine like a weird, weak beta blocker. And like beta blockers you still need to be careful with taking it with other drugs that can decrease blood pressure like benzo's. Of course taking reasonable amounts of both can be safe and therapeutically beneficial, but it can still be fatal even though they don't interact in a way that potentiates, they just work alongside eachother. However that doesn't make it completely safe. But if you are on this website, we all know safety is relative.
paranoid android said:
I once injected clonidine and morphine and the shit took my breath away. Fuck clonidne i dont like that shit really
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Im prescribed alot of opioids and clonidine. I don't feel like I'm taking more morphine and hydromorph when I take clonidine.
I quit fentanyl a few weeks ago and clonidine helped with the sweating and helped me feel less anxious and sleepy but nothing felt stronger.
@paranoid android shooing clonidine? Dam that's alot of filler. Make her stop.
 
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