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Bupe Does being on subs RAISE your opiate tolerance......

bdomihizayka

bdomihizayka

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Jul 30, 2012
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Let's say someone was doing a couple percs a day.... and then went on a standard 8mg of bupe. A bit overkill for such a small addiction. But happens all the time.

Is this going to completely mess up their opiate tolerance in the future?? Meaning, you will probably need higher opiate doses, and your tolerance will skyrocket faster than before once off the subs?

I read forums where some people argue being on bupe and away from "real" opiates actually lowers your tolerance....which makes no sense to me.

Anyone have any input?
 
I understand that the bupe and whatever opiate compete for opioid receptors; so yes.
 
If the dose of sub is way more than "equipotent" as compared to your normal opiate dose, then it almost certainly would. I did a quick sub taper recently, only taking enough to hold me for my 30 mg a day oxy habit. That turned out to be between .5 and 1 mg sublingual. I'm guessing that I didn't do too much damage to my tolerance.
 
Being on Bupe for 2 years skyrocketted my tolerance. I was doing 160mg oxy/day (2 x 80mg OC's, the original ones not the OP's) or around 5 bags of east cost dope when no oxy.

I got on Bupe at 24mg/day and over 2 years dropped down to 4mg/day when I relapsed due to an injury that needed painkillers. Anyway, I nneded to take double what I used to just to feel something--doing 4 x 80mg oxy per day or 10+ bags of dope and within 1 year I waas up to over 1,000mg's oxy per day or 20 bags of dope. I wasn't really feeling my doses so kept on raising them to try and get high. It honestly felt like the bupe had somehow permenantly raised my tolerance....
 
Yes, buprenorphine does increase opioid tolerance. In my opinion pharmaceutical companies keep lying to us all about the effective dose. At the very beginning after switching to buprenorphine, a higher dose may really be needed because of tolerance developed with the previously used full agonist, and one has to get used to the "subtle" relief given by buprenorphnie. For an addict it does so little though and both its pharmacokinetics and pharmacodynamics make it unnecessary to continue large doses once a patient is more or less stable mentally. At least lowering such tolerance isn't so painful as with full agonists. Right now I'm at 2mg and I don't feel like getting back at 8mg, but I do feel like nodding out with morphine or heroin and forgetting about the shit around me...

With methadone it's kind of different though, I couldn't feel equally good on a higher dose and on a lower dose after tapering down. I had to quit it completely to feel a difference.
 
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