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Opioids Does anyone know what fentanyl is being bulked with?

Dr. John Thackery

Dr. John Thackery

Bluelighter
Joined
Nov 21, 2025
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353
i know tell me what’s in my dope threads aren’t allowed so just curious if anyone knows what fentanyl is bulked with these days generally?

i also have a question at the end about rectal use.

why i ask:

i used to do a ton of fentanyl in the early 2000s. It was completely pure by mass spec since i had recrystalized it into beautiful flat clear uniform crystals. and the fact that you would vape a barley visible spec of it to get a strong high. i would also abuse extracted patches.

i hadn’t done it for almost 20 years. i’ve been on methadone and other pharma opioids since.

so i got some of the fentanyl that exists today and was first surprised that its a hard rock like a crack rock.

a small piece of it hits pretty hard so it’s not cut to shit but certainly 100x or so by weight.

i strip tested it with basically every drug strip test you can buy for opioids and tranquilizers ….like 12 different tests including xylazine, nitazenes, other designer opioids and tranquilizers….the only thing it tested positive for is fentanyl.

it has the exact same taste as 100% pure fent; but holy shit does it make me sick after. a splitting axe headache, ears ringing and nausea for days after that isn’t opioid derived nausea.

what the fuck do they put in this shit and it’s so toxic feeling that it’s not even worth being on…i’m baffled by how ppl could want to stay on that drug mixture rather than get on methadone….and this fent doesn’t even have xylazine. i can’t imagine how nasty tranq dope is.

when i was using pure fent 20 years ago i also used some that was not recrystslized and contained synthetic impurities by mass spec but that never caused sickness.



i threw it away before i remebered maybe trying it rectally, it seems like the least awful and damaging way would be rectal. i’m wondering if all these horrible side effects i got will also be present rectally or are the result of vaporizing whatever contaminants or bulking agent is used.
 
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In new england, where my program is we generally see fentanyl cut with Inositol, mannitol, and cellulose as primary bulks, often with caffiene and loads of byproduct. Sometimes benzos, fent analogs, nitazenes here and there. But almost always the primary cut is either mannitol, inositol, cellulose, or protein powder
 
RustyCrackleford said:
In new england, where my program is we generally see fentanyl cut with Inositol, mannitol, and cellulose as primary bulks, often with caffiene and loads of byproduct. Sometimes benzos, fent analogs, nitazenes here and there. But almost always the primary cut is either mannitol, inositol, cellulose, or protein powder
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smoking such a small amount of any of those carbohydrates or caffiene couldn’t possible cause these headaches and nausea that lasts for days.

i’ve smoked drugs heavily cut with mannitol and it didn’t cause any side effects

i’m thinking there’s got to be a decent amount of some reagent left in there.

but i’ve smoked fent in the past that was somewhat sloppily made and just acid base extracted and not recrystslized or anything and it didn’t make me so sick.


other than for severe physical pain…..i cannot for the life of me imagine why anyone would get into opioids in this era.

i remember loading up oxy 30s or dilaided into a rig and slamming it or even heroin and it was the cleanest smoothest high with no nasty after or side effects.

if i tried todays fentanyl for the first time i would not be motivated to ever touch that shit again.
 
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chippermonk said:
Medetomidine apparently became very common as an adulterant over the past couple years, becoming more common than xylazine. Nasty, dangerous sounding stuff. But I have never taken fentanyl and have no first hand knowledge, this is from news articles I have read
For eg below, but there are plenty of other reports

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i tested for that compound and it was negative.


i can’t imagine how shitty of a high this drug mixture is with xylazine i don’t understand why ppl even keep doing it. a high dose of methadone is honestly way better of a high and way cheaper not to mention safer
 
Dr. John Thackery said:
i tested for that compound and it was negative.


i can’t imagine how shitty of a high this drug mixture is with xylazine i don’t understand why ppl even keep doing it. a high dose of methadone is honestly way better of a high and way cheaper not to mention safer
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There is basically no high from xylazine + fent. You either sleep or go into a dreamlike blackout state, where you can hurt yourself and not even know it. I have never met a single person who said that they "liked the high." Most likely, the reason people are using it is because they weren't testing their drugs and got hooked without knowing... at least that is what happened to me amd folks I know.

Then, when you want to get off of the ride, you find out that there are no protocols in place to comfortablely detox you for as long as you need to be detoxed. I went through the process 3 times before I was able to figure it out. I was only able to stay clean by a miracle -- I found a woman who sold me a script of ativan and was able to use those and taper off until the wds subsided to a place where I could tolerate and walk off. Honestly though, if my stupid pcp would have just given me a script for clonidine like I asked, I don't think the ativan would have been necessary. I'm so lucky that I didn't walk away from this whole mess with a benzo addiction.
 
Damnit_Wonda said:
There is basically no high from xylazine + fent. You either sleep or go into a dreamlike blackout state, where you can hurt yourself and not even know it. I have never met a single person who said that they "liked the high." Most likely, the reason people are using it is because they weren't testing their drugs and got hooked without knowing... at least that is what happened to me amd folks I know.

Then, when you want to get off of the ride, you find out that there are no protocols in place to comfortablely detox you for as long as you need to be detoxed. I went through the process 3 times before I was able to figure it out. I was only able to stay clean by a miracle -- I found a woman who sold me a script of ativan and was able to use those and taper off until the wds subsided to a place where I could tolerate and walk off. Honestly though, if my stupid pcp would have just given me a script for clonidine like I asked, I don't think the ativan would have been necessary. I'm so lucky that I didn't walk away from this whole mess with a benzo addiction.
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it’s crazy that addition medicine has not considered the xylazine dependency aspect of this addiction.

i’d call it gross incompetence but i think it’s actually they are doing it on purposes an the want ppl to stay in this killer drug.



but what you describe about the high just being a lights out blackout / go to sleep . that’s the exact type of high i like the most.
 
Dr. John Thackery said:
it’s crazy that addition medicine has not considered the xylazine dependency aspect of this addiction.

i’d call it gross incompetence but i think it’s actually they are doing it on purposes an the want ppl to stay in this killer drug.



but what you describe about the high just being a lights out blackout / go to sleep . that’s the exact type of high i like the most.
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I would hope that after 3 or 4 years of this, they have protocols in place now.

What was the craziest part for me, was that my methadone clinic kept raising my dose, even after they tested me for xylazine. I'm curious to know if they added xylazine to the dt panel because it had to be tested separately when I was dealing with this. I kept telling the nurses and the doctor that the methadone did NOTHING for the xylazine withdrawal and that my heart rate and blood pressure would still shoot through the roof. I ended up on such a high mg before they decided to tell me that I had to go to detox or get out. Like over 200mg. At that point, walking off of 200+ mg of methadone seemed just as scary as the xylazine, so I went to detox. I only planned to go for a week because I had a job that wouldn't wait 28 days for me and believe it or not, the job had no clue what I was going through or at least the extent of it. After 3 days, the rehab moved me from detox, even though my blood pressure was still spiking. After the 6th day, I was so ready to go anyway because they weren't helping me and I felt like I still should have been in detox. I made it another 2 days out of the rehab and was still in withdrawals, so... I was back at it, but making my own treatment plan, which I was then able to execute and finally kick for good.

While I loved a good opiate nap/sleep, xylazine was different. When you wake up, you feel shitty as hell. It fucks with your stomach and blood sugar, so you constantly feel like your stomach is eating itself. Idk, maybe there are some folks out there who like the stuff, but I have yet to meet one IRL.
 
Dr. John Thackery said:
not that i know of. there is no maintenance program for the typical illicit “fentanyl” addict

a detox will definitely address the xylazine dependency but that’s not maintenance
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The xylazine maintenance is walking into a doctor or just straight up buying clonidine online and tapering it...
 
Dr. John Thackery said:
taper xylazine mixed with fent? not the best system.
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You taper clonidine. You will need to drop the fent. You're doing maintenance remember? And if you're doing so much fentanyl that even high dose methadone ain't gonna cut it, then you're going to need to taper your adulterated fent/tranq too. Wanna get clean? Suck it up buttercup...
 
drewbocop said:
You taper clonidine. You will need to drop the fent. You're doing maintenance remember? And if you're doing so much fentanyl that even high dose methadone ain't gonna cut it, then you're going to need to taper your adulterated fent/tranq too. Wanna get clean? Suck it up buttercup...
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i don’t use xylazine or fentanyl so it’s not my problem. i just have an interest in all things drugs.
 
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