Cim.... we're nowhere near being able to entirely simulate the human body.
Nowhere close at all! I can't emphasize enough how much of a pipe dream that is right now. It's a nice thought, but still far, far, faaar away.
It's not that we just need motivation or funding for this; there's tons of work being done on computer modelling and simulation in biology & medicine. (I'm not sure why so many people seem to think that scientists are so shortsighted that there wouldn't be.) It's just that the body is so fucking complicated, and there's so incredibly much we don't understand -- really we have barely scratched the surface in terms of what's going on. Simulations and computer models are just getting to the point where they're any good at all for anything.... to suggest that they could replace lab/animal research in the foreseeable future just boggles my mind.
I don't know how to convey just how incredibly much knowledge and how complex of a system we're talking about here. A couple years ago I worked down in San Diego; I drove back and forth with a guy I knew who was doing neurobio research at the Scripps Insitute there. He was working on a simulating just the electrical properties of
a single neuron. Just one; it took a while to simulate only a few seconds of activity, and God knows how accurate it was. In the human brain there are 100 billion neurons -- you would need hundreds of gigabytes of memory merely to list them all....
Most drugs are still discovered totally accidentally. We're still trying to figure out the basic mechanisms of disorders like Alzheimer's that have had billions of dollars sunk into them... and for each such mechanism we figure out, there are thousands, tens of thousands, more we're still totally clueless about....
On the heart model -- not sure what you're talking about, but there are many heart models out there, some better than others, all very limited and incredible simplifications.
Here's some links I pulled up on this... some various computational biology groups I know about... check them out to get a feel for the scale of the field....
http://www.cns.caltech.edu/
http://www.cds.caltech.edu/~hsauro/links.htm
http://www.molsci.org/Dispatch?action-NavbarWidget:-project=1&NavbarWidget:-project=alpha
http://www.bioeng.auckland.ac.nz/physiome/physiome_project.php
http://www.stanford.edu/group/pandegroup/folding/science.html
Cimora said:
The homestatic function/regulation, is one of the few things we can actually learn reliably from animal brain studies. Some animals can teach us some things, but often not very much and at a fairly high price in suffering.
On the contrary, they're pretty much the only way we can learn about biology. Look, pick any recent advance in large-scale (eg more than just pure biochem/molecular bio) biology, and try and tell me how it could have been achieved without the use of animals models. Can you?
Theres a great degree of incompatibility between species that in actuality probably shouldnt be acceptable as a safety standard. Hell animal studies in general can be pretty dicey. God knows the number of toxins, carcinogens, neurotoxins and other nasties weve approved on the back of animal testing only to fuck a whole bunch of folks up because oops were wrong.
They aren't acceptable as a safety standard. Nothing is approved merely on the back of animal testing. For FDA approval, there are three phases of human trials (typically ~50,~200,and ~2000 people) that must be done.
But animal trials invaluable not only for finding these drugs in the first place, but for filtering out many of the really toxic ones, determining which adverse reactions/side fx to keep an eye out for, learning the drug's mechanism to inform about probably interactions, develop more effective variants of the drug, and so on. Consider that every toxic drug that's caught in animal trials -- the vast majority -- would otherwise have to be tested on humans, and you'd have a bunch of people disabled or dead instead of rats or rabbits.
Neurological drugs are at the high end of this tip of incompatibility, especially for many of the modern purposes such as anti-epileptic, anti-depression, anti-psychotic, anti-anxiety and pain/sleep meds which involve some high level function specific to humans.
True. But in many cases even these drugs aren't on functions specific to humans; usually they target older systems and mechanisms in the brain that are fairly conserved across all mammals. I don't know of a single drug that affects the kind of high-level cortex function unique to humans (probably with good reason -- no animals to do research on!) Most mammals have an anxiety system built in the amygdala; they can all have seizures, they all sleep, etc.
And yet monkeys, which are fairly evolved animals are being used, having their brains munched as a safety standard for drugs for which their is no true correlation of safety.
Research is very rarely done with monkeys, partially because of cost, partially because of ethical concerns. In safety trials, typically rats & rabbits would be used, or mice & pigs.
You and vegan both seem to think that because there's not a perfect correlation between toxic effects in animals and people, there must be no correlation at all. But there'a big range between 0% and 100%! Some quick googling reveals that 70%+ of toxic reactions are caught in animal trials.
Take prozac. Long term users now have brain damage, like mdma axon damage.
Can you point me to your reference for this? I saw a few papers suggesting something along those lines a couple years ago, but they were all extremely sketchy, borderline effects. I thought they'd all failed to find any support for the idea -- has there been some new research I missed?