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Does Abilify block some of the effects of opiates?

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blase deviant

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I know it regulates dopamine, but how much does dopamine affect how much pleasure you get from opiates, and how much does abilify block it?
 
jasoncrest said:
#5. I read in many pages that neuroleptics/anti-psychotics can precipitate withdrawal symptoms in Methadone-addicted patients.
Here are 2 sources, there are many more on google:

http://content.karger.com/ProdukteDB...name=83097.pdf

http://www.psychopharmacology.com/pt...856145!8091!-1

What's the mechanism? How can neuroleptics put an opiate-addict in withdrawal?
Neuroleptics don't work on opiate receptors, right?
They are mostly dopamine D2 antagonists...
Click to expand...

Here's something I asked on a thread in Advanced Drugs Discussion.

Can Dopamine Antagonists (Anti-psychotics/neuroleptics) block or reduce the recreational effects from Opiates (or even precipitate withdrawals like in few the cases in the links)?

Abilify is a different anti-psychotic from the others, from what the doctors say, it increases Dopamine when you don't have enough, and blocks it when you have too much...

Is this true?

What does Abilify do with Opiates then?
 
Abilify is a weak partial dopamine agonist (D2 & D3) if I recall… the theory being that in a dopamine saturated environment it will act as a de facto antagonist and in a very dopamine scarce environment it will act as a an agonist. It is hoped that its pseudo-antagonist properties will decrease ‘positive’ psychotic symptoms and its agonist properties will improve ‘negative’ symptoms as well. In actual clinical practice it is really about the only antipsychotic medication that is somewhat activating and really weight neutral. As to what degree it will modulate the effects of an opiate… I guess it really depends on which opiate(s) and which effect(s) as Abilify does not have a simplistic interaction with dopamine. It also modulates some dopamine effects through its action on serotonin as well.

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I just noticed because I had some morphine and a percocet a few days ago and didn't get anywhere near the pleasure or a nod as I used to. No tolerance issues either.
 
Anti-psychs mainly work as dopamine antagonists. Dopamine is often cited as a critical neurotransmitter in the "pleasure pathway." So I am sure any anti-psychs will diminish the pleasurable effects of drugs of abuse.
 
*Bump*.. i'm also curious as to any experiences out there involving abilify and methadone.. my doctor just started me on abilify and he claimed that it would make the methadone "work better".. but he would not elaborate on this.. does he know that abilify will block some of the effects of methadone?.. and is that why he would say it will make it work better?.. just concerned.. I have heard positive feedback about abilify tho for bi-polar.. as to its effects on opiates, is another story?..
 
So far as I know it only sort of limits them, if you take opiates you will sttill feel the effects.
 
opiates while taking abilify

while i don't condone it, I do say from experience that I have never noticed it making any difference whatsoever. Though I do have a tolerance to both drugs and have always taken high doses of both.
 
Does not block, but does diminish..........I have an outstanding beef with abilify but I wont rant on about it in detail.......
 
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