Do you get unusual or unexpected effects from drugs?

[Tronica]

Hi Drug Culture

I have a journalist friend who is seeking input from people who have had unusual and unexpected effects from psychoactive drugs (any types).

It's an interesting question - most people I know with unusual responses to drugs have a reason for it, e.g. a medication they are on or as a result of medical procedures that might have permanently changed their responses, or due to ADHD or other neurodivergence.

Jenny is someone I can personally vouch for. You could use an anon/encrypted email if concerned.

You can read more about her work at http://www.jennyvalentish.com/ and https://twitter.com/jennyvalentish

Here's her pitch for your consideration:

I'm writing a story for Vice Global about how people have can have quite odd physiological effects to drugs – be it someone who gets revved up on sedatives, or calmed down by stimulants (though that's fairly well established, so I'd prefer different examples), or gets sleepy, aggressive or manic responses to a substance that most do not, or has an reliably adverse reaction to something, or finds that some things don't affect them at all. I'd then be talking to pharmacologists about my case studies, so if you've always wondered why something is the case, now's your chance! Names will be changed, of course. To take part in an email Q&A, please contact [email protected] by Thurs Mar 12, 2020. Be prepared I'll need to ask about: dose, route of administration, the behaviour, and whether you're on any medication.

Thanks everyone for your support.

I'll post the resulting Vice article back on this thread for you to check out later.

ALSO I thought it'd be an interesting discussion to have in this thread... are you one of these people who has the opposite or unexpected reaction to a drug? Or it just doesn't affect you? If so, what happened and how do you deal with it?

Thanks
Tronica

 

[azf]

my wife swallowed 80mg mdma and got a rather big nose bleed.

(note: she has never snorted anything in her life)

 

[G_Chem]

Cocaine can sometimes act as an antidepressant if I use it very infrequently, like couple times a year. I think it has to do with its sigma agonism. Anything more than that and I’m paying for it like everyone else.

-GC

 

[Shinji Ikari]

This thread is from 4 years ago but I'll leave it open as it might be fun to discuss.

The resulting Vice article can be found here.

 

[azf]

Thanks for sharing the article, will give it a read.

I might as well add, my wife has generally weird effects from substances.

Weed is legal in WA state and wife and I would on occasion get some edibles. These would have 10mg THC per candy. If I consumed 2, I would be high af, 3 would have me, to borrow a term from my pot head brother: "zooted". I never dared goes past 3. My wife, with even less experience with Weed than me, would barely feel anything.

To prove the point, I once watched her eat 6 of them at once, while I ate just 2. She said she felt a bit relaxed but otherwise normal. She said she would have been able to drive no problem, whereas if I were to try and drive I would make it to the 1st intersection, stop at a red light, wait for it to turn green and then have no idea how long it had been green before I was able to become aware and start driving. My sense of time was broken whenever I got high. Her on triple the THC, relaxed, oh and she did get the munchies.

14mg 2CB gave her severe restless leg syndrome, so perhaps she has a magnesium or other vitamin deficiency?

150mg 4MMC oral roa made her very productive and she was able to knock some chores out. No sexual effects.

25mg Meth oral roa makes her hyper focus on taking notes, lasts about 12 hours. She can't eat a thing. Any more than 25mg and she gets very depressed the following day. I've literally never experienced any sadness from meth so I struggle to understand her experience, though I am aware it is a common side effect.

Benzedrex (Propylhexedrine) interestingly enough, gives her 0 comedown and nice head tingles; but most importantly: makes her very horny. It's maybe the only thing that has reliably (and drastically) increased her libido.

I doubt anyone prefers Benzedrex over Meth, but at least when it comes to my wife and sex, for reasons unknown, Benzedrex is the clear winner.

Thanks for listening to my Ted Talk.

 

[Jabberwocky]

I got aggressive and manic/very restless feeling from s-ketamine and shrooms a while ago, i thought i was k-holing on my bed but actually i wsa standing up and shouting/growling to my man, for No reason at all! I was full of anger and were aggressive towards him and i never ever normally behave like that. It was scary and confusing, i felt deeply ashamed afterwards and felt really distorted and anxious. Very strange!

I'm experienced with ketamine and usually it feels good, relaxing, soothing.
I'm also experienced with shrooms, and with that combo (shroomsbwith ket).
And i love that combo. Last time it felt bad and confusing and Anxious. I don't know why.
Does anyone have any suggestions why that can happened? Does anyone else get aggressive while on ket?

 

[Miche31]

Thanks for sharing the article, will give it a read.

I might as well add, my wife has generally weird effects from substances.

Weed is legal in WA state and wife and I would on occasion get some edibles. These would have 10mg THC per candy. If I consumed 2, I would be high af, 3 would have me, to borrow a term from my pot head brother: "zooted". I never dared goes past 3. My wife, with even less experience with Weed than me, would barely feel anything.

To prove the point, I once watched her eat 6 of them at once, while I ate just 2. She said she felt a bit relaxed but otherwise normal. She said she would have been able to drive no problem, whereas if I were to try and drive I would make it to the 1st intersection, stop at a red light, wait for it to turn green and then have no idea how long it had been green before I was able to become aware and start driving. My sense of time was broken whenever I got high. Her on triple the THC, relaxed, oh and she did get the munchies.

14mg 2CB gave her severe restless leg syndrome, so perhaps she has a magnesium or other vitamin deficiency?

150mg 4MMC oral roa made her very productive and she was able to knock some chores out. No sexual effects.

25mg Meth oral roa makes her hyper focus on taking notes, lasts about 12 hours. She can't eat a thing. Any more than 25mg and she gets very depressed the following day. I've literally never experienced any sadness from meth so I struggle to understand her experience, though I am aware it is a common side effect.

Benzedrex (Propylhexedrine) interestingly enough, gives her 0 comedown and nice head tingles; but most importantly: makes her very horny. It's maybe the only thing that has reliably (and drastically) increased her libido.

I doubt anyone prefers Benzedrex over Meth, but at least when it comes to my wife and sex, for reasons unknown, Benzedrex is the clear winner.

Thanks for listening to my Ted Talk.

How did she take the benzedrex? I like the thought of increased libido lol.

 

[Shinji Ikari]

I got aggressive and manic/very restless feeling from s-ketamine and shrooms a while ago, i thought i was k-holing on my bed but actually i wsa standing up and shouting/growling to my man, for No reason at all! I was full of anger and were aggressive towards him and i never ever normally behave like that. It was scary and confusing, i felt deeply ashamed afterwards and felt really distorted and anxious. Very strange!

I'm experienced with ketamine and usually it feels good, relaxing, soothing.
I'm also experienced with shrooms, and with that combo (shroomsbwith ket).
And i love that combo. Last time it felt bad and confusing and Anxious. I don't know why.
Does anyone have any suggestions why that can happened? Does anyone else get aggressive while on ket?

I have heard of people becoming aggressive or even hypersexual on ketamine but haven't had any unusually unusual experiences with it myself.

I've only mixed shrooms and ketamine the once and it was scary. I had to put a Studio Ghibli film on to calm myself down

 

[PsychCat]

I get very strong entactogen-like effects using gabapentin. I feel such a longing to be around others and be fully open and close to them. I haven’t heard anyone else talk about it. It makes me very curious as to what mdma feels like since it’s most well known for being a potent entactogen. Maybe I’m just feel that effect more strongly? Or maybe I process gabapentin differently? Whatever it is I find it very interesting.

I also have schizoid personality disorder which means I have almost zero interest in having close friends or partners. I’m single and have no close friends nor do I want that to change but after taking 2.4g of gabapentin I desperately want to have a partner and everyone I know is my very good friend.

 

[golego55]

I get very strong entactogen-like effects using gabapentin. I feel such a longing to be around others and be fully open and close to them. I haven’t heard anyone else talk about it. It makes me very curious as to what mdma feels like since it’s most well known for being a potent entactogen. Maybe I’m just feel that effect more strongly? Or maybe I process gabapentin differently? Whatever it is I find it very interesting.

I also have schizoid personality disorder which means I have almost zero interest in having close friends or partners. I’m single and have no close friends nor do I want that to change but after taking 2.4g of gabapentin I desperately want to have a partner and everyone I know is my very good friend.

This is interesting.

It's weird but depending on the dosage I get a similar effect with lamotrigine, which like gabapentin is also an anticonvulsant. I suffer from social anxiety, social anxiety disorder, and depression. Normally I can't handle being around most other people but for some reason (dose dependent) lamictal allows me to want and seek others.

 

[PsychCat]

This is interesting.

It's weird but depending on the dosage I get a similar effect with lamotrigine, which like gabapentin is also an anticonvulsant. I suffer from social anxiety, social anxiety disorder, and depression. Normally I can't handle being around most other people but for some reason (dose dependent) lamictal allows me to want and seek others.

Very interesting. I am unfamiliar with lamotrigine but from some quick googling they both seem to have the same pharmacology. I also have some social anxiety and moderate depression so maybe it’s related to that? It’s cool to know I’m not the only one who gets that sort of effect with this gabaergic drugs.

 

[Cult315]

I get very strong entactogen-like effects using gabapentin. I feel such a longing to be around others and be fully open and close to them. I haven’t heard anyone else talk about it. It makes me very curious as to what mdma feels like since it’s most well known for being a potent entactogen. Maybe I’m just feel that effect more strongly? Or maybe I process gabapentin differently? Whatever it is I find it very interesting.

I also have schizoid personality disorder which means I have almost zero interest in having close friends or partners. I’m single and have no close friends nor do I want that to change but after taking 2.4g of gabapentin I desperately want to have a partner and everyone I know is my very good friend.

I actually have the same effects from larger doses of gabapentin. I avoid taking it in a large dose all at once for that reason as I tend to become too open with whoever will listen lol. I’ll share shit all day long openly online or with some random person I’ve met that’s ya know, using the same drugs as me - but in person at places like work or an event like my kids school meetings I definitely should not divulging my drug habits on unsuspecting strangers which has happened at least twice that I recall, not counting the random other bits of personal information that shouldn’t be shared that I have in fact shared.

Definitely a very strange effect for it to have. I can take 300mg at a time every hour all day long and my secrets are safe, but for some reason taking a single large dose has a super extrovert truth serum effect on me.

 

[golego55]

Definitely a very strange effect for it to have. I can take 300mg at a time every hour all day long and my secrets are safe, but for some reason taking a single large dose has a super extrovert truth serum effect on me.

That's exactly how it works with lamictal and I. For me these days it's at least 400mg in one "dose", and the fun kicks off. Taking a dose 100+ greater about 17-22 hours later has an effect that's significantly dulled. There seems to be a refractory period where if I take another big dose >36-48 hours, there's little effect. But wait 48 hrs (or ideally longer) and the original "big isolated dose" effects return.

 

[Cult315]

That's exactly how it works with lamictal and I. For me these days it's at least 400mg in one "dose", and the fun kicks off. Taking a dose 100+ greater about 17-22 hours later has an effect that's significantly dulled. There seems to be a refractory period where if I take another big dose >36-48 hours, there's little effect. But wait 48 hrs (or ideally longer) and the original "big isolated dose" effects return.

Yeah it’s the same with gabapentin. Re-dosing later on or the next day never has the same effect as tolerance to it rises immediately. Honestly if I were to probably double the dose or so it would likely have a repeat effect, but I’m not really willing to swallow that many pills at once unless they’d be giving me a much better buzz lol.

I technically have an “unlimited” supply of them, a family member I live with get a script of 100/month and takes at most 1/3 of them each month, usually far less, so there’s bottle after bottle just hanging out. But I learned my lesson a long time ago about becoming dependent on something that 1) doesn’t belong to me, as free and unused as it may be and 2) something seemingly unlimited, cause it always has an end at some point then you’re in withdrawal and supply-less

 

[golego55]

Yeah it’s the same with gabapentin. Re-dosing later on or the next day never has the same effect as tolerance to it rises immediately. Honestly if I were to probably double the dose or so it would likely have a repeat effect, but I’m not really willing to swallow that many pills at once unless they’d be giving me a much better buzz lol.

I technically have an “unlimited” supply of them, a family member I live with get a script of 100/month and takes at most 1/3 of them each month, usually far less, so there’s bottle after bottle just hanging out. But I learned my lesson a long time ago about becoming dependent on something that 1) doesn’t belong to me, as free and unused as it may be and 2) something seemingly unlimited, cause it always has an end at some point then you’re in withdrawal and supply-less

It doesn't sound like you're doing anything particularly dangerous, but please stay safe and happy and healthy.

 

[Cult315]

It doesn't sound like you're doing anything particularly dangerous, but please stay safe and happy and healthy.

My danger days are gone(aside from a current meth habit), just mostly mean I don’t need to add another unnecessary addiction lol. I can’t imagine gabas are too hard to come off of, and with my personality and track record I could easily be eating 3g+ a day for particularly no reason as they don’t have much of an effect at all after the first time I do them in a while. And the unwillingness to swallow them by the handful kinda goes hand in hand with the mentioned meth use - no matter how much I drink my damn throat is always dry and it’s just unpleasant to try and scarf down a bunch of capsules. Don’t quote me on this as I’m sure it is possible, but I don’t think I could even swallow enough of them to OD to an actual damaging effect. They’re pretty harmless, I just mentioned the unlimited access and addiction because the last time I had “unlimited” access to a medication it was Tramadol, and while I can’t see gabapentin becoming anywhere near as bad, that got out of control fast as fuck. Lol

I just use these on days where I can’t score my usual, and I used them a bit when I first started coming off of subs this most recent time(still going). Not sure exactly how long it’s been now, just checked the last message I sent the main girl I used to get them from and said “I’m dying” on the 3rd so I’m guessing at least 15 days, which tbh is farther than I thought I was. I think it was even longer actually but kinda counted a “restart” cause I’d found a few pieces and bags with subutex powder laying around the house before I went to a concert out of town on the 6th. Think I found enough for a very light 2-3 day supply and that shit set me back to square 1 WD wise lol. Should’ve just left it be