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Do you get immuned to comedowns the more you do MDMA?

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My first few times on MDMA I had significant "Tuesday blues". Crying for almost no reason, crushing depression that would last a couple days. But as I have been using MDMA more frequently (2-4 times per month) I have noticed I do not get this depression at all anymore. I just might feel a little groggy or hungover the day after, but emotionally I have no depression or sadness anymore.

The rolls aren't as good as the first ones were as you might have guessed. Where they differ is mostly in the physical/body high area. Empathy/euphoria/mild psychedelica is still at the same levels. I just don't have that amazing intense body/rush and waves of orgasm like body rushes squeezing out of my brain into my body as I'm rolling anymore, which sucks and I'm hoping I can get that back if I take a break from rolling.

Seems to be on this forum that people suffering the worst comedowns are first time or "early career" users thus I was lead to ask this question as it was sort of what I experienced. Also, read that people that do the drug a lot eventually run into comedown problems as well. With me though it seems that increased use and getting used to the drug has eliminated my comedowns from even happening anymore. Thoughts? anybody have the same experience?
 
What? That's ridiculous.


As you get lower and lower in serotonin, the negative effects and "comedowns" will be more and more pronounced. Many people seem to get away with using with little to no side effects, for a while. It almost ALWAYS catches up to them after continued abuse of the drug.

You simply need to look at the way the drug works to realize that you will not be able to use in this pattern for long periods of time. You may be able to get away with it now, but if you think you can continue this pattern of abuse for any extended period of time, you'll be posing a "comedown thread" very soon, I'm sure.
 
Hi i'm a recent first time user and have only done it once. But during my comedown i ended up researching mdma for 8 hours nonstop. So maybe i can help out.

you are over doing it for starters. its recommended to only do it once a month. Your brain has to replenish its serotonin and that takes time. this is the reason why you aren't getting that body high anymore. And since you've been doing it 2-4 times per month. I'd recommend finding a new hobby, going out and being more active for about 2-3 months without using any ex. i say get a hobby to keep yourself occupied. but remember do this to stay healthy, not to roll again. As far as becoming immune to come downs. I think its possible to build a tolerence to it. I mean you already know what to expect and your just use to it now. but hmm chill out on the rolling for a while :) good luck!
 
Folley said:
What? That's ridiculous.


As you get lower and lower in serotonin, the negative effects and "comedowns" will be more and more pronounced. Many people seem to get away with using with little to no side effects, for a while. It almost ALWAYS catches up to them after continued abuse of the drug.

You simply need to look at the way the drug works to realize that you will not be able to use in this pattern for long periods of time. You may be able to get away with it now, but if you think you can continue this pattern of abuse for any extended period of time, you'll be posing a "comedown thread" very soon, I'm sure.
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Where is the proof that I'm getting lower in serotonin? I don't feel like I am at all. Just because others do, maybe I don't or maybe I make it back faster or maybe other drugs that I use counteract serotonin depletion or 5-HT receptor up/downregulation in some lucky way that balances me out. Where are the scientific papers that say it takes one month to replenish your serotonin fully? I hear a bunch of 19 year old kids saying that on this forum but I have never read the scientific papers. Is this "theory" based on animal experiments? I have not idea what this "theory" that everyone takes for gold is really based on, what kind of science it is based on. So I refuse to believe it as true, for everybody, (especially since I myself and others I know experience otherwise) unless I read the science papers myself that have led to this Golden rule of 1 month being necessary to reset your neurochemistry.....whose to say it isn't one week for me?

I can't take some random person on the internets advice as being gold just because it is what they read some other randome person wrote on bluelight. Maybe for the majority of people it does take one whole month, but maybe for others it only takes one week, we are all smart enough to know that people's brains and bodies are very different and work in different ways, especially when mixes of drugs are being used by these people also.



I do agree with the theory the above poster put that maybe the reason I don't get that amazing body rush anymore is because I may be running low on serotonin. But this "lowness" should I have it, is not resulting in Tuesday blues, like it did after my first times on mdma, after which my serotonin level should have been much higher still than it is nowdays...so by that logic I should have worse depression now after mdma, which I don't.

It's obviously not as simple as everybody thinks it is.
 
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LOL


Yeah, I'm sure you're different from everyone else in the world. I've seen so many people say the same thing, then go into HORRIBLE comedowns and swear off MDMA for months at a time.

Really, read what you are saying. It's pure denial. I'm not going to waste time out of my day googling so you can continue to rationalize your drug problem.
 
I am not the only person that uses this much, there are many people that use much more and don't have problems they just aren't on here on bl announcing it to the world. I agree that it is riskful to continue using any drug regularly for a long time. I am just very curious and posted this thread because I seem to be experiencing the opposite of what is predicted, and know others that use much more than I do that don't have all these comedown problems either. Its a totally valid question based on observed real users of mdma and not denial. If you're gonna start trying to explain neurochemistry to me to explain why i'm going to fuck up my brain eventually I'm going to need some citations otherwise your words are just words.

I am not in denial and trying to rationalize my drug use,,,,I am just asking a question about why what I am experiencing seems to be different from what all these people on this board complaining about their comedowns are experiencing, and maybe we can draw some shady conclusions about what contributes to or prevents comedowns.
 
Some people are more prone to these problems then others, or took piperazine or something similar at the start of their career. That would be why some people seem to be suffering more greatly than others.


So, you're not dealing with comedowns now... do you want to keep pushing it until you do? I used to be like you, think that just because I felt fine the next day that no damage was being done. I rolled practically every week with little problems, I just kept doing it because it seemed fine. While it may work for a while, eventually it will catch up to you as it did for me. I was naive and didn't even think about it, here you are denying an entire forum's experience and stating that SOMEHOW, you have a brain that is different from every other creature in the world.




Unfortunately, neurotoxicity in humans is not often studied due to moral concerns. You can't just pump a human with a half gram of MDMA every week to study what will happen lol... but here.

http://jop.sagepub.com/content/20/2/211.short
http://onlinelibrary.wiley.com/doi/...sCustomisedMessage=&userIsAuthenticated=false


and in animals:
http://www.jneurosci.org/content/8/8/2788.short
http://stke.sciencemag.org/cgi/content/abstract/sci;297/5590/2260
http://link.springer.com/article/10.1007/s00213-006-0322-6#page-1




You should be glad you're not getting comedowns now, and use responsibly to keep it that way. Continuing to use in this pattern until you get those negative effects is just.. retarded.
 
This is everything that is wrong with the world. everyone thinks they are special and it won't happen to them...then whem it happens to them they want everyone to bend over backwards to help them fix it.
 
You come here for advice and in return all i see is retaliation. No respect, and you claim that we are wrong. I, am new here so I very much could be wrong. But some of these members are years old and very experienced (with using, helping, researching, scientific knowledge, common knowledge) So please refrain from justifying ur drug abuse and making a claim that you are a chosen one. Please excuse me for sounds offensive I don't mean to be too rude. But i mean look at it the way we have to. You come here for help with ur question, then you say our answers are wrong and your answer is right. Why did you come here for an answer anyways if you are hooked on what your mind thinks? Believe us on what we say please. Do not destroy your body/mind/personality because getting high feels good. Get high for the experience, not because your bored.

Edit:
And gain more self control. Challenge yourself to go 1 month without ANY substance. Just to test yourself. If you get urges, then you know that you could possibly be having a problem, so resist.
 
Folley said:
Some people are more prone to these problems then others, or took piperazine or something similar at the start of their career. That would be why some people seem to be suffering more greatly than others.


So, you're not dealing with comedowns now... do you want to keep pushing it until you do? I used to be like you, think that just because I felt fine the next day that no damage was being done. I rolled practically every week with little problems, I just kept doing it because it seemed fine. While it may work for a while, eventually it will catch up to you as it did for me. I was naive and didn't even think about it, here you are denying an entire forum's experience and stating that SOMEHOW, you have a brain that is different from every other creature in the world.




Unfortunately, neurotoxicity in humans is not often studied due to moral concerns. You can't just pump a human with a half gram of MDMA every week to study what will happen lol... but here.

http://jop.sagepub.com/content/20/2/211.short
http://onlinelibrary.wiley.com/doi/...sCustomisedMessage=&userIsAuthenticated=false


and in animals:
http://www.jneurosci.org/content/8/8/2788.short
http://stke.sciencemag.org/cgi/content/abstract/sci;297/5590/2260
http://link.springer.com/article/10.1007/s00213-006-0322-6#page-1




You should be glad you're not getting comedowns now, and use responsibly to keep it that way. Continuing to use in this pattern until you get those negative effects is just.. retarded.
Click to expand...



And how do we know that neurotoxicity happening is what is connected to each individual symptom of a comedown?

I don't think I am invincible, I think that I am thinking about it and the possible long term consequences hence my reading this board and asking these questions and making these discussions. I do try to limit my rolling to twice a month and it is only 120-150 mg per use. I try to do it as little as possible...but the perfect setting or outing or social situation seems to arise more than once a month and temptation is a bitch. I just try to do it when it is a good opportunity to enhance the experience, I don't sit at home on a weeknight and take mdma just to "get off". These stories all sound very horrible and I do consider them and hope to decrease my rolling to once a month, but like I said...temptation is a bitch.


sorry if I ruffled all of your feathers, I am not saying that what happened to some of you cannot happen to me....I am saying it isn't happening to me and others right now, and wondering what the differences are or why I am personally observing my comedowns to decrease as use continues....that was really my main question in posting this thread: why have my comedowns decreased or vanished as use continued...which for many people seems to be the opposite.
 
I just want to also state that to a certain degree. we are all the same. You will ruth the day you argued with these people on the forum. When the come downs come, be prepared. And stop being so dam logical. there are some things we just simply cannot explain with science so maybe there are no "papers" for it yet. but its common sense.
 
LucidSDreamr said:
sorry if I ruffled all of your feathers, I am not saying that what happened to some of you cannot happen to me....I am saying it isn't happening to me and others right now, and wondering what the differences are or why I am personally observing my comedowns to decrease as use continues....that was really my main question in posting this thread: why have my comedowns decreased or vanished as use continued...which for many people seems to be the opposite.
Click to expand...

like everyone has said before. YOU WILL GET THEM JUST WAIT!!!!!!!
 
soinamity said:
I just want to also state that to a certain degree. we are all the same. You will ruth the day you argued with these people on the forum. When the come downs come, be prepared. And stop being so dam logical. there are some things we just simply cannot explain with science so maybe there are no "papers" for it yet. but its common sense.
Click to expand...


I am arguing that there is no proof of a set frequency of use that is safe and more than that is dangerous....some people fuk themselves by using 100mg twice a year, others do it every weekend 500mg and are unscathed, the argument I am making is that people telling me to go from 2-4 times a month to 1 time a month has no real backing behind it to be considered safe....obviously the safe thing to do would be never to touch it again, or to only do it once a year at 100mg dosage.

I did say that I feel slightly hungover the next day (but no longer have depression)...so obviously this drug is bad for me. while other drugs such as phenethylamines do not give me any hangover whatsoever and actually improve my feeling for days after. serotonin releasers (mdma apb's etc) are harsh drugs, and I do not think I am immune to their taxation on the body just to make that clear.
 
Why do some people trigger months of anxiety and depression from just one roll when others can abuse it weekly for many months? Why can I drink 12 beers in a night and be ok and my buddy has 3 and he is done for?

Everyone's brain chemistry is different. But, at the end of the day, everyone is mortal.
 
@ dawglaw. Lol i can trip like 7 tabs of lsd and see dragons, ice mountains, flying unicorns and all sorts of shit, while still being able to drive perfectly. Others can take half of 1, and are done for. (I'm just agreeing with you)
 
One thing I noticed is that the hungover day after feeling I describe, is non existant almost during times I am using MXE as compared to periods where I am off of MXE. MXE I think has serotonin re uptake inhibitory action. They also tell you to take Prozac (an SSRI) after rolling to decrease damage or comedowns or whatever. I wonder if my side use of SRI's has any effect on me not feeling the comedowns as much.

This is aside to the fact that over the grand scheme of things (when SRI's have not been consumed by me at all, ie mxe) I still observed this "lessening of depression associated with comedowns" after my x use started to increase in frequency.
 
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You are the one person in the world who can take MDMA weekly without suffering from consequenses, you are very special and unique.
 
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In my experience using various drugs with comedown effects, I've found it therapeutic to

A) Smoke a lot of weed the following day(s)
B) Be constantly aware that I am in a comedown period, so any depressing thoughts I am having are associated with the comedown.

Smoking weed makes me even more forgetful than I already am, thus making it wonderful for "forgetting" those depressing thoughts.
I have had some pretty bad issues with depression since age 11 or 12, and I have used my fair share of drugs, starting with weed and alcohol at 16, then by 17 cocaine and whatever else someone threw in front of my face. Luckily none of my friends did heroin, because at that age I would have been all for it. I've done acid, shrooms, molly and x, xanax, percs and oxys, and I've experienced my fair share of comedowns. I do not do these drugs nearly as often as I used to, preferring a quieter lifestyle now.

You will, more likely than not, eventually experience pretty bad comedown. Our brains are so mysterious to us despite the fact that they're the organ that makes us conscious and intelligent. I believe that we have the ability to control, or attempt to control, certain aspects of our consciousness. It is possible to control your emotions simply by telling yourself to feel a certain way. Smiling influences your brain to be happy , pointing to my point that you can control that shit.

You have not eliminated the comedowns, you just have not experienced them in a while. If you medicate during the comedown period, yes, that will affect whether or not a comedown is consciously experienced.

Just be careful, because months of kicking your brain back and forth, even just a few times a month, can have detrimental effects. One of my good friend's has fried his brain because he went H.A.M. on coke and molly for way too long.





Educate yourself with credible sources on the topic, and just please be careful; especially if you have increased usage. Do not let it become more than once a week. Do it less than once a week.
 
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