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  • BDD Moderators: Keif’ Richards

Do u think that codeine has a ceiling dose?

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Anon54

Ex-Bluelighter
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Jun 11, 2010
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Codeine feels really good when I take it but I find the effect a little subtle. It would be great if it were possible to take larger doses to get a stronger effect now that I have become tolerant to the side effects.
Only problem is the so called ceiling effect whidh claims taking more than approx 400mg wont increase the effect. But can anybody confirm this with any kind of study & source?

Quote from Wikipedia
Codeine is metabolized to C6G by uridine diphosphate glucuronosyl transferase UGT2B7, and, since only about 5% of codeine is metabolized by cytochrome P450 CYP2D6, the current evidence is that C6G is the primary active compound.[14] Claims about the supposed "ceiling effect" of codeine doses seemed to rest on the assumption that high doses of codeine saturated CYP2D6, which prevented further conversion of codeine to morphine, which is simply incorrect.[citation needed]
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I tried drinking 600mg of codeine today with 40mg temazepam so feel OK %)
Unfortunetely the Codeine only feels the same as if I were to take 400mg but I probably can't tell anyway because of tolerance.
I suppose u'd have to take atleast double to really test if there is a difference.
Anybody ever tried drinking amounts over the so called ceiling dose & felt a stronger efffects?
 
I usually use around 800mg of codeine in a dose and do believe I feel it more strongly than 400mg. However, I think it's hard to estimate how much codeine you're actually left with after your cold water extraction, and I wouldn't be surprised if 50% or more of the codeine was lost in an extraction. Therefore when I think I'm doing 800mg, I'm probably actually getting much less.

I do believe there is a ceiling dose though, as there does come a point where increasing tolerance makes codeine pretty much useless, no matter how much you do. I've done over a gram in one go before and while I did find it more effective than 800mg, it was only slightly. It would make sense that different people have a different ceiling dose, and that this could be affected with potentiators.
 
Codeine was always a hit and miss for me. There would be days where I'd do a CWE and I'd get a pretty decent buzz going. Then there would be days where I'd do exactly the same method of CWE and feel fuck all. This is taking into account tolerance. I don't know what to make of it. I've read somewhere (forget where) that codeine has weak affinity for the mu-opioid receptor. Then I read somewhere else that it's also only a partial agonist. Then again, the whole issue with whether its effects are felt from its conversion to morphine via CYP2D6, or its glucuronidation to codeine-6-glucuronide, or both. I lost count a long time ago how many bottles of Tylenol 1 I've gone through, but I still have no idea if codeine has a ceiling dose.
 
The effects of codeine are indeed due to morphine and codeine-6-glucuronide (the active metabolites).
There is a ceiling dose, but it is based on your individual biology...basically when your CYP2D6 is saturated (used up), you cannot convert anymore codeine into it's previously mentioned active metabolites. 300-400mg is listed as the ceiling dose because, on average, this is how much codeine it would take for CYP2D6 to become saturated in most of the population.
 
bump ^^ regarding your post do u have any sources to back up this theory or what the ceiling dose average for most the population.

just as a 1 off im going to take .8 grams of codeine instead of .4
i'll let yas know if there is an increased effect. i will be very happy if the effect is actually doubled.
Ive also had 50mg valium topday but benzos barely do shit to me.

any other experieces of injesting larger than the so called ceiling dose of codeine or any links to info regarding its ceiling dose. Please re-read the quote from wikipedia i added in my original post it says that there isn't a ceiling dose.

so experiences or sources are what im looking for
 
ok so just ingest 800mg minus what i lostduring cwe but im a pro at doing it. so far ive noticed the typical fragerance i usually get on my breath but stronger. its only been 5 mins but it usally hits me in about 10 mins. i dunno if that placebo or not but it always seens to kick in in only 10 mins. fingures crossed i get a stronger effect tha just .4 grams
 
unfortenetly it doesnt feel stronger. i do feel like having a nap though after the codeine & valium
note that i have a tolerance to codeine & 400mg doesnt really do anything any more.. only seems to help a bit for about an hr. maybe it's time for a break
 
Anon54 said:
unfortenetly it doesnt feel stronger. i do feel like having a nap though after the codeine & valium
note that i have a tolerance to codeine & 400mg doesnt really do anything any more.. only seems to help a bit for about an hr. maybe it's time for a break
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Why is the reason that codeine at 400mgs doesnt effect you much anymore? Is it because you moved on to harder opiates or just that codeine ran its course?
 
just had 400mg i feel it a bit but only really get a mild sense of well being for 45 mins.
nah havnt touched harder opiates. yeah ive treied oxy, hydro, morphine, tramadol, dhc PST, & fentanyl at the hospital. but they were all very rare occationsions.. they were never habbbits. Ive never touched needles or h. Im tempted to sniff a buit one time but i think i may be playing with fire. atleasts with pharms ya know what ya getting. its clean & not made in back yard laboritories. I think codeine does cause a tolerance to oppiates. cuz i got presribed oxycontin 15mg after i got my wisom teeth taken out & they did shit all even at 75mg. I actually needed to take 4 isntant rlease endons (5mg oxy) to even feel a thing cuz i got them as well.
someone gave me an 80mg oxycontin. took it didnt do much either... i shweed it up though so mim not sure if that breaks the time release. but still 80mg even slow realease still should be strong
i must have just got a tolerance. i remember not having codeine for a year & than cwe a packet. & i felt like i was floating & had drowsiness & everything. it was a little euphoric. so it just shows u can actually lower ya tolerance
 
just had 400mg i feel it a bit but only really get a mild sense of well being for 45 mins.
nah havnt touched harder opiates. yeah ive treied oxy, hydro, morphine, tramadol, dhc PST, & fentanyl at the hospital. but they were all very rare occationsions.. they were never habbbits. Ive never touched needles or h. Im tempted to sniff a buit one time but i think i may be playing with fire. atleasts with pharms ya know what ya getting. its clean & not made in back yard laboritories. I think codeine does cause a tolerance to oppiates. cuz i got presribed oxycontin 15mg after i got my wisom teeth taken out & they did shit all even at 75mg. I actually needed to take 4 isntant rlease endons (5mg oxy) to even feel a thing cuz i got them as well.
someone gave me an 80mg oxycontin. took it didnt do much either... i shweed it up though so mim not sure if that breaks the time release. but still 80mg even slow realease still should be strong
i must have just got a tolerance. i remember not having codeine for a year & than cwe a packet. & i felt like i was floating & had drowsiness & everything. it was a little euphoric. so it just shows u can actually lower ya tolerance

just had my codeine. does anyone else get a nice sent on there breath after they take opiates?

ppl take sedating antihistamines to inshase the sedation. i wonder if the antipychotic im currently prescribed would help. i mean it is an antihistamine. but i wouldnt take it during the day.

antipychotics get a bad rap. day before yestday i had 40mg diaz & 40mg temaz & it only calmed me down.

5mg zyprexa puts me right to sleep & they actually presribe it up to 20mg. even the otc sedating histamine phenergan (promtherzine is more sedating than 40mg temaz.
havnt tried diphenhydramine. but have tried doxlamine & ts not as good as phenergan.


theres still a debate weather anthistamines potenetiate codeine. i dont think anyone really knows. obviously it increases the sedation but i want it to make the opipate effect stronger.
 
The only true way to potentiate codeine would be to interfere with it's metabolism in some way. A lot of "potentiators" just increase the sedation as you rightly said. I know there is a lot of debate about the ceiling effect (do a search - plenty of threads) but personally I haven't actually looked into it much as anything above 500mg is far too much histamine for me to handle! The new(ish) ideas about which metabolite gives most of the opiate effect certainly make debate reasonable I think.. however BDD isn't really the place for such a debate, being primarily a quick q&a forum.. so I'm going to close this.

Anyone interested, I'd recommend doing a search and reading the many other threads about this :)
 
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