Do Sodium Valproate as significant anxiolytic effect ?

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Do Sodium Valproate have significant anxiolytic effect ?

Sodium valproate is a weak blocker of sodium ion channels; it is also a weak inhibitor of enzymes that deactivate GABA such as GABA transaminase. It may also stimulate the synthesis of GABA, but the direct mechanism is not known.

I would like to know do it have significant anxiolytic effect ?

AND

What kind of effect should I espect ?

 

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Also since it is a GABA reutake inhibitor, I know a lot of drugs would probably be bad to be mixed with it.

Would AH-7921 be safe to mix with it ?
Would any GABA agonist be safe to use in low dose with it ?

 

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It been 24h and over 100 views since I post it and I still have no awnser so I wonder, would this thread better in OD ?

 

[Mysterie]

have you read this article? http://onlinelibrary.wiley.com/doi/10.1002/ddr.430250408/abstract

also i havent heard of anyone using sodium valproate so i doubt its recreational

 

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I dont want to use it recreationaly but as an anxiolytic if it have this property.

Thanks for the link.

 

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Does anybody have an experience with this chemical to share ?

 

[Mysterie]

any substance with a significant anxiolytic effect, is recreational for people with anxiety

have a read of this thread, it should answer most of ur questions

 

[mrflowers00]

it's mostly used for bipolar disorder if memory serves me correct hence could relieve anxiety to an extent but i wouldn't be recreational in a similar fashion to benzos nor as relaxing but if your just looking for something to ease the anxiety just a little (significantly less than benzos) it could be worth a try

 

[paranoid android]

I was put on divalproex for bipolar disorder a good few years ago and i also suffer from anxiety. I was on clonazepam at the time and that was controlling most of my anxiety but i didn't notice any added anti-anxiety effect or potentiation of the effects of the clonazepam. It didn't even cause any drowsiness or fatigue with me. So it didn't seem to do anything at all for my anxiety and most other people i know who have been on it for mania, as a anti-convulsant or to help prevent migraines have said that it didn't seem to help any anxiety they had either. Actually i did ask a psychiatrist if valproate had any anti-anxiety effects and she said that the vast majority of her patients got no anti-anxiety effect from it. It's probably the number 1 drug used here to treat bipolar disorder or atleast the first drug tried for it but almost everyone i know who has bipolar disorder is also on a benzo to treat their anxiety.

As for possible drug interactions i know it can react very badly with aspirin as aspirin can raise the levels of valproate in the blood stream. It can be effected or effect the metabolism of some other drugs especially enzyme inducers such as phenobarbital, carbamazepine and phenytoin. I was prescribed it while also being prescribed clonazepam and various opiates (mostly morphine and dilaudid but also Demerol, oxycodone and fentanyl) and had no noticeable interaction. But i have no idea as to what AH-7921 is except from what i have read on wiki that it's a Mu opioid agonist. If that's all there is to it the valproate shouldn't effect it any differently then other opioids.

 

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Thanks for the Thread link and experiences, I have enough information for now it seem it does not have significant anxiolytic effect and act mostly as a mood stabilizer.

 

[Limpet_Chicken]

Just be aware, that if you are female, valproate MUST NOT BE TAKEN DURING PREGNANCY!

It causes a fetal valproate syndrome, characterised by severe brain damage and accompanying mental retardation, if the fetus survives. Its highly teratogenic.