Do psychedelic amphetamines retain NT release like AMP?

[PsychedelicDoctor]

Talking about the DOX class here. Do any of these compounds act as releasers or is all their action mitigated through 5-HT agonism?

 

[Roger&Me]

Talking about the DOX class here. Do any of these compounds act as releasers or is all their action mitigated through 5-HT agonism?

The effects of the psychedelic amphetamines are mediated through serotonergic agonism. They aren't monoamine releasers, and don't share a pharmacological similarity to amphetamine; they are considered "amphetamines" only in reference to their structure. The best piece of evidence for their pharmacological dissimilarity is that the major active isomer of amphetamine has the S configuration at the alpha carbon, and the major active isomer of DOx compounds have the R configuration at the alpha carbon; therefore they cannot be active at the same sites, because of their differing orientations in 3d space.