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Opioids Do opiates/opioids have cross-tolerances?

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Stan the man

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Jan 30, 2012
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If I build a high tolerance to morphine or oxycodone, would that effect my tolerance to hydrocodone or oxymorphone? Fentanyl? Suboxone?
(These are just random opiates/opioids)
 
absolutely. if you constantly take strong opiates such as morphine, dilaudid etc. the weak ones like codeine will have less and less of an effect on you
 
100% yes. I remember when I was transitioning to dope instead of oxy for a while there I was going back and forth.. until I realized what good dope was. For the price of one 30mg oxy IR I was getting 4 bags of dope which was at the least equal to 120mg oxy..

Generally speaking up in North Jersey 1 bag which are only 20-40mg is equal or better than sniffing a 30mg oxy. It's crazy how much alike they are.. I thought dope woudl be something crazy but the high was practically the same just a little longer.

IVing is a different world though.. Those 4 bags for the price of 1 oxy I mentioned above turned into having like 4x oc 80s lol. Oxy def blows to IV compared to dope.. the rush is non existant compared to a good bag of d.
 
Yes, they cause cross tolerance.

It will already have your tolerance much higher (although not equal to the new drug), but as soon as you start the new drug it will skyrocket to the same level almost immediately.

Good comparison: Almost like weed. If you smoke all the time your tolerance is up. Puff on a new strain and its slightly better for a day or w/e then right back to where it was.
 
Yes.

Just like if you were to use MDMA, tolerance to Methylone/Mephedrone etc would increase.

It's all to do with the receptors the substances act on. If they act on the same ones, tolerance to the others will develop.
 
Not really OD material, of course opioids have cross-tolerance, especially full agonists to full agonists. The cross tolerance isn't always complete but it's there.

I'm closing this now, PM if you have any questions.
 
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