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Do dissociatives effect serotonin (levels, receptors etc) at all?

A

albany_force

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May 19, 2009
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This might be a very basic question but some googling didn't really yield me any results. As for why I'm wondering you can check out my thread history (MASSIVE meph overdose resulting in REDICULOUS tolerance, borderline immunity, to serotinergetic drugs).

I'm very grateful for any help :)

The specific drug I'm having in mind is 4-MeO-PCP, but the question probably applies to most if not all dissociatives out there.

Thanks in advance.
 
Some of them do, can't quite remember if 4-MeO-PCP does. I can't link the chart currently but a quick google or look in an older PD thread will show you the affinities of the newer diss's including 4-MeO-PCP.

Edit: NVM found it for you, http://bluelight.org/vb/archive/index.php/t-649843.html. It appears it does have SERT affinity from a quick glance.
 
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Help?!?! said:
Some of them do, can't quite remember if 4-MeO-PCP does. I can't link the chart currently but a quick google or look in an older PD thread will show you the affinities of the newer diss's including 4-MeO-PCP.

Edit: NVM found it for you, http://bluelight.org/vb/archive/index.php/t-649843.html. It appears it does have SERT affinity from a quick glance.
Click to expand...

Thank you for the help.

Any idea of just how diminished the effects are going to get when someone like myself (that for some reason doesn't get anything out of seorotonergetic drugs) would do aforementioned substance?

You'd think I'll have an enjoyable experience or would it perhaps just be a waste, or even strange?

I'm completely new regarding dissociatives btw!
 
albany_force said:
Thank you for the help.

Any idea of just how diminished the effects are going to get when someone like myself (that for some reason doesn't get anything out of seorotonergetic drugs) would do aforementioned substance?

You'd think I'll have an enjoyable experience or would it perhaps just be a waste, or even strange?

I'm completely new regarding dissociatives btw!
Click to expand...

The experience might be a little less "warm". That's all. Tolerance to the SRI effect with these drugs builds extremely rapidly and it's not what most people want out of these drugs anyway. Their main effect is NMDA antagonism and your tolerance to serotonergics won't affect that.
 
Toz said:
The experience might be a little less "warm". That's all. Tolerance to the SRI effect with these drugs builds extremely rapidly and it's not what most people want out of these drugs anyway. Their main effect is NMDA antagonism and your tolerance to serotonergics won't affect that.
Click to expand...

Al right, I will try out 4-meo-pcp very, very soon, hopefully I will have a nice time :)

Thanks all.
 
This is better suited for ADD / NeuroPharm forum since that expertise would best answer the question at hand.... moving from PD.

It does seem like a_f is satisfied with the answer but I am personally curious about what we know of ketamine, MXE and PCX 's actions on serotonin. For example MXE's SERT action is still listed as putative in our wiki.
 
Solipsis said:
This is better suited for ADD / NeuroPharm forum since that expertise would best answer the question at hand.... moving from PD.

It does seem like a_f is satisfied with the answer but I am personally curious about what we know of ketamine, MXE and PCX 's actions on serotonin. For example MXE's SERT action is still listed as putative in our wiki.
Click to expand...

With regards to ketamine, I can recall a scientific article I read from the NCBI stating that Ketamine has the ability to inhibit SERT synthesis/metabolism in living organisms. The following is taken directly out of the article:

"
Since ketamine did not affect brain tryptophan levels nor did it inhibit 5-HT in vitro, the reduction of 5-HT turnover following ketamine administration appears to be a neuronal, adaptive phenomenon possibly occurring in response to a blockade of 5-HT uptake by ketamine (Martin LL)"​
 
I remember reading somewhere that NMDA antagonists can increase extracellular 5-HT concentrations in some parts of the brain. Will post if I recall more details/where I got this from.
 
The hallucinations you get while high on dissociatives, are they related to sert activity or not?

Any ideas as to where the CEOs derive from?

I have yet to try my 4 MeO PCP btw... It'll happen soon.
 
sekio said:
Given that they're present from NMDA-selective compounds (e.g. MK801), I'm going to go with 'no'.
Click to expand...

It's true that the SERT-affinity of MK-801/dizocilpine is too low to have any effects (43 µM), but I wouldn't call it "NMDA-selective", because it also has a very high affinity (0.3 nM) for the functional high-affinity state of the dopamine D2 receptor:

http://www.ncbi.nlm.nih.gov/pubmed/15852061
 
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