DMT + SRA (Tianeptine ) + MAOA (moclobemidum) + MAOB (Deprenyl)

[gate one]

DMT 100mg + SRA (Tianeptine) 12,5mg + MAO-A (moclobemidum) 150mg + MAO-B (L-deprenyl) 5mg.
Phenetylamine, tyramine, octopamine, tryptamine free diet. and stimulans restricted for 4 weeks.

My friend told me that SWIM tried this combination.
This is what my frined told me:
SWIMs first effects came after half an our on an empty stomach. His two frinds were full of colours. He coud not talk to them. He struggled to keep his attention. White/blue light filled the room. And the light was made of zillions of molecules, all vibrating. Sounds from the outside disdisappeared. He could still see but could not hear. New vibrating sound filled his body. Nausea at that time was 5+! He could hardly stand, but he made it to toilet. His hands were cold and whole body was shivering. He was cold like the dead. Very strong physical effect. All came very fast. Its one our from administration. SWIM fell near toilet unconcious. But he fell like he knew where to fall. His heart was pumping strong and fast! He had pulse, but his skin was pale and cold. He opened eyes after few seconds, but he could not keep them open. After 2 ours he was ok, but he was exhausted.

Dose anyone have experience with something similar? Any advices? Can you, at least, tell what you think about it. Thank you, and sorry for my bad english.

 

[nAON]

In general, wouldn't recommend combining MAOIs with any drug, due the the clusterfuck of side effects associated with their use.

Not too sure about the direction you want this thread to go, would you rather have it moved to Trip Reports?

 

[ro4eva]

I respectfully think - at least up until the last paragraph - that this is trip reports or blog material.

To answer your question though. Combining a SERT uptake inhibiting psychedelic with a SSRE and then on top of that, adding an irreversible MAO-B inhibitor, which at higher doses is also shown to irreversibly inhibit MAO-A - and then adding another MAO inhibitor... Potentially massive case of serotonin syndrome as well as hypertensive crisis and possibly psychosis. I think it's a very dangerous cocktail of drugs as well as a very bad idea.

 

[gate one]

Tianeptine is a substance enhancing serotonin uptake while sertraline and clomipramine inhibit it. By means of 5-hydroxyin-doleacetic acid (5-HIAA) voltammetric measurements, this study investigated their influence on serotonin metabolism which depends mainly upon the activity of monoamine oxidase type A. After tianeptine injection the 5-HIAA signal increased by about 60%. This effect was maintained when the animals were pre-treated with MDL 72145 (an inhibitor of monoamine oxidase type B) but reduced when clorgyline (an inhibitor of monoamine oxidase type A) was administered after tianeptine. Administration of sertraline or clomipramine reduced the 5-HIAA signal by about 30-50%, whether the animals were pre-treated with MDL 72145 or not. It is to be concluded that tianeptine, sertraline and clomipramine can regulate the 5-HT fraction present in the synaptic cleft, not only by acting at the level of the serotoninergic neurons, but also by favoring or reducing the access of the amine to monoamine oxidase type A which is synthesized within non-serotoninergic neurons and glial cells.

 

[gate one]

do you get the idea now?
Tianeptine is SRA. There is an investigation of using MAOB with tianepitne, but i can not find it. Tianeptine is not only sretonin reuptake enhancer but also serotonin metabolism accelerator. So its reducing 5-HT fraction present in the synaptic cleft.
DMT has receptor sites on 5HT R and sigma one, probably more R.
MAO and MAOB was used to make it available to make its effects. Tianptine was used to "clear" his receptor sites. More available receptor sites more DMT can make an effect.
I now about dangers of serotonin syndrome but my friend did not have symptoms of seroto. syndrome. He has used MAOA and MAOB for some time with no unwonted reactions. And he has used MAOA and MAOB with full dosage of tianeptine. Only mild headek, and it was gone after three days. Dosage were: tianeptine 3x12,5 moclobemidum 2x150mg deprenyl 5mg under tong in the morning.

 

[ro4eva]

I understand that DMT doesn't work very well without a MAOI but what I was trying to propose is that since it also appears to inhibit SERT and VMAT2 (inhibiting serotonin uptake via both of those pathways), would it not possibly act as a catalyst for SS after Tianeptine's SSRE / metabolism effects are at least partially counteracted, thus, leaving a larger fraction of 5-HT in the synaptic cleft, with MAOIA/B inhibited?

Also, again, since VMAT2, MAOIA and B are inhibited, and with DMT having affinity for D1 as well as Tianeptine modulating D2/3 + enhancing dopamine levels in the nucleus accumbens - I was postulating that this could lead to a hypertensive crisis and possibly psychosis.

But usually I just talk out of my ass about these things. My ass being copying and pasting shit. So I can't know for sure and sometimes I get confused so I don't reply.