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Dissolving Marinol to make a spray/tincture

RockyThunder

Greenlighter
Joined
Dec 21, 2013
Messages
2
Location
USA
Hi everyone,

I'm a first time poster so I'm sorry if this might belong in a different forum, but we're dealing with prescription thc pills here.

So, I have been prescribed Marinol for three years now, for appetite stimulation and reduction of nausea related to side effects from various organ transplant medications. It works amazingly and has definitely made my quality of life better.

Now, it does have three major problems. First it must be refrigerated. It is fine out of the fridge for two or three days but after that they're useless. Second, when I take them, they can take anywhere from 45 min to 8 hours to come on, leaning more towards the 8 hours side of things if taken during the day and towards the 45 min side of things at night. Third, there is no way to accurately control the dosage. Most of the time, 5mg is just right. . Occasionally, it's not enough. Occasionally, it can be so strong that I feel like my life is a movie and I'm just the audience.

I have no idea why they are like this. I always figured that the company that made it engineered it with some weird quirks to keep it from working too well so that they could continue to try to deceive the general public into thinking that marijuana can't be a viable medicine. Well, the other day I came up with an idea to possibly make it work better.

What I would like to do is dissolve the Liquid inside the Marinol capsules into a solvent that could then be sprayed or dropped sublingually, in standardized dosages, so that I can get exactly the desired effect without waiting forever for it to hit. The oil inside the capsules alone does not work.

The liquid inside the capsules is just sesame oil with synthetic THC dissolved in it. My bright idea was to use high proof ethanol as a solvent, however, according to a quick google search, this would only be able to partially dissolve the sesame oil. Before I go and try to find out just how partial partially is, I am looking for some informed advice from anyone with a knowledge of chemistry out there.

1. Will the ethanol work?
2. If it won't, can anyone suggest any other possible solvents that are also healthy to be ingesting.

(Before anyone says it, I know real cannabis is better and that I could brew up a tincture with the real stuff. Unfortunately due to other cannaboids that seem to have a GFJ-like effect on some of the transplant medications, this is out of the question)

Thank you for any help you guys can offer!

-The Rocky Thunder
 
Ethanol should work well, try and get everclear or similar, and a bottle of 'essence of' whatever flavour you want.

If you wanted to test it first just get a 50ml vodka miniature they're only a couple of quid/dollars.
 
Apparently sesame oil's only slightly soluble in alcohol (link), I'm not sure adding alcohol would make it more effective sublingually anyway. And does it even work sublingually? Seems sativex takes a little longer, if anything, to be absorbed than a similar oral dose of THC (study).

Your best bet might to be try and get it to work more consistently orally. I guess it would be absorbed quickest on a fairly empty stomach, eaten with a bit of something fatty if you can.
 
Apparently sesame oil's only slightly soluble in alcohol (link), I'm not sure adding alcohol would make it more effective sublingually anyway. And does it even work sublingually? Seems sativex takes a little longer, if anything, to be absorbed than a similar oral dose of THC (study).

Your best bet might to be try and get it to work more consistently orally. I guess it would be absorbed quickest on a fairly empty stomach, eaten with a bit of something fatty if you can.


Yeah trust me, in three years, I've tried all kinds of different ways of taking it orally, there is just no rhyme or reason to the things. I've read about tinctures, and I just thought I'd try an experiment. I'll let everyone know how it goes when I give the everclear a try.

Thanks for the replies!
 
It has a steep oral dose curve for me. 20-30mg and I don't feel anything. 40mg is just right. I'm stoned but can function fine. 60mg I'm so stoned I stagger around like I'm drunk and I can't go out in public. No fun at that level.
 
It has a steep oral dose curve for me. 20-30mg and I don't feel anything. 40mg is just right. I'm stoned but can function fine. 60mg I'm so stoned I stagger around like I'm drunk and I can't go out in public. No fun at that level.

Interesting, I never tried taking that much. I'm prescribed 2x5mg/day for nausea but I rarely take it anymore now that I have access to medicinal. I found it was just too unreliable, even taking it daily as soon as I woke up. It could be helpful but sometimes it just didn't work, and sometimes I'd get insatiably hungry (which was more desirable, as I could use to gain 20+ pounds).
Mostly I found just a minor stone that really became kind of unnoticeable after taking it daily for a while. I thought it left me with more of a general cognitive haze than natural flowers though, and definitely moreso than oil.
I never tried mixing it with anything but I was always interested, seeing as it's just sesame oil. But the amount is so small you'd either have to use a huge amount of capsules or make it single-serving somehow...
 
I always figured that the company that made it engineered it with some weird quirks to keep it from working too well so that they could continue to try to deceive the general public into thinking that marijuana can't be a viable medicine.
....The liquid inside the capsules is just sesame oil with synthetic THC dissolved in it. My bright idea was to use high proof ethanol as a solvent, however, according to a quick google search, this would only be able to partially dissolve the sesame oil. Before I go and try to find out just how partial partially is, I am looking for some informed advice from anyone with a knowledge of chemistry out there.


If [ethanol] won't, can anyone suggest any other possible solvents that are also healthy to be ingesting.

(Before anyone says it, I know real cannabis is better and that I could brew up a tincture with the real stuff. Unfortunately due to other cannaboids that seem to have a GFJ-like effect on some of the transplant medications, this is out of the question)

Thank you for any help you guys can offer!

-The Rocky Thunder
Ethanol is not "healthy to be ingesting".
Grape fruit juice (GFJ) interacts adversely with quite a few medications. Perhaps some of your medications are having adverse interaction with Marinol.
You are probably storing it in your refrigerator's door, which does not keep the medication at a consistent temperature and, from the sound of it, would greatly impact the strength of the Marinol. You could buy some new medication, store it correctly, and see if that solves your issues.
Let your doctor's office know so that the problem can get resolved, both for yourself and other patients.
Do not alter your medication. That means putting yourself at risk.
 
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