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dissociatives / arylcyclohexylamines pharmacology

Nagelfar said:
Certain "off-opioids" (e.g. Herkinorin) are "hallucinogenic" purportedly, interesting that the other handed isomer of Ketamine from its dissociative effects are not traditional opioid affective but hallucinogenic as such (again, purportedly). Leading me to think it may be from a type of mu-agonism common to the g-coupled protein which elicits a non-analgesic response from the receptor. (probably from a particular way of binding)
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herkinorin is a derivative of salvinorin, and also acts as a kappa-opioid-receptor agonist, so I guess it should produce effects pretty similar to salvia divinorum: http://en.wikipedia.org/wiki/Herkinorin .

another interesting compound that goes in this direction is dextrallorphan. it is similar to DXM and acts as σ1 receptor agonist, κ-opioid receptor agonist and NMDA receptor antagonist: http://en.wikipedia.org/wiki/Dextrallorphan .
 
ungelesene_bettlek said:
herkinorin is a derivative of salvinorin, and also acts as a kappa-opioid-receptor agonist, so I guess it should produce effects pretty similar to salvia divinorum: http://en.wikipedia.org/wiki/Herkinorin
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Yes but in that very article you quoted, it informs that Herkinorin is exceedingly selective for the mu receptor over the kappa in contrast to its parent compound.
 
I think there's a lot of confusion here, it is common fact atm that non-opioid/nmda/cholinergic hallucinogens work on a combo of serotogenic AGONISM mixed with some sort of glycoprotein effect. Not as direct effect of dopamine agonism and LSD's antagonism is overshadowed by its agonism so I think people should stop stating unproven speculation as fact
 
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