daddysgone
Bluelighter
- Joined
- Oct 22, 2007
- Messages
- 1,114
Don't matter - a drug has to be in solution to cross the blood brain barrier
???? what do u mean by this?
How does a drug have to be "in solution" to cross the BBB?
N&PD Moderators: Skorpio | someguyontheinternet
Don't matter - a drug has to be in solution to cross the blood brain barrier
Diffusion - doesn't happen if not in solution (unless you have big holes in your BBB!)
it could be that these findings are BS. I know people in pharma ind.. If u think for second that alotta shady shit dont go down like it does in anyother big ind. like banking/oil/cigarettes etc... think again. I would not b surprised if these results wer bias or even that the study wasn't performed right :/
Are there any lawsuits against the administration of ORLAMM?Does anybody have any information or ideas as to why diphenoxylate has all of the characteristics of other opiates (abuse potential, substitutes for others in preventing withdrawl, reduces gastric motility, depresses breathing etc) but shows no properties as an analgesic. I was under the impression that if a drug was a mu receptor agonist, then it would also have analgesic properties.
Any insights would be appreciated
I see this is a very old thread but it caught my interest. How did they classify this compound as an opioid, by receptor screening or by naloxone challenge? If the second then it doesn't have to be an opioid. Naloxone also causes nasty symptoms with dissociatives for example, I reacted horribly (no physical w/d but mental symtoms like agony, loneliness and tears) to it when I had no opioid tolerance at all and just memantine in my system.
Yeah, thought about that but naltrexone is routinously given to alcoholics with seemingly little side effects in comparison. Both are antagonists which turn into inverse agonists when tolerance is present. Would think it'd hit the alchoholics similarly like it did me but this doesn't seem to be much of an issue. I had a low, single digit figure of naloxone (from part of a tilidin/naltrexone pill I crushed and snorted, believing the naloxone would only work when injected) and the effects were, while short lived, heavy and hard to bear. Possibly does memantine in higher dosages than usually used (I had 40mg/d if I remember correctly) release endorphines? Idk.That could’ve also been due to it blocking your normal endo opioids, hard to say in that case..
Yeah, thought about that but naltrexone is routinously given to alcoholics with seemingly little side effects in comparison. Both are antagonists which turn into inverse agonists when tolerance is present. Would think it'd hit the alchoholics similarly like it did me but this doesn't seem to be much of an issue. I had a low, single digit figure of naloxone (from part of a tilidin/naltrexone pill I crushed and snorted, believing the naloxone would only work when injected) and the effects were, while short lived, heavy and hard to bear. Possibly does memantine in higher dosages than usually used (I had 40mg/d if I remember correctly) release endorphines? Idk.