• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Diphenidine

Bare_head

Bare_head

Bluelighter
Joined
Jun 7, 2005
Messages
3,051
Location
UK
So guys this chem i am very interested/skeptical in, i know user reports but be interested to know what the pharm discussion has to say on them chemical its self
 
sekio said:
It's not been screened, I don't think.

I'd expect it to have similar pharmacology to PCP. Tocris sez it's a "high affinity antagonist at the NMDA receptor".
Click to expand...

This is pure speculation, but do you think heat or metabolism could produce an amphetamine-like byproduct? Some of the trip reports about vaporizing Diphenidine hint at a euphoric/addictive/stimulative effect, which completely contradicts the reports of oral usage I've heard.

It's unlike PCP in that it has two aromatic rings, attached by short alkyl chains... it seems like one of the phenyl rings could get broken off along with the piperidine ring. Then you'd get something like alpha methyl phenethylpiperidine... which looks like the lovechild of amphetamine and benzylpiperazine.

Does this seem at all plausible?
 
Last edited:
No, if anything you would get elimination to 1,2-diphenylethene and piperidine. Even if the phenyl ring got blown off it would be 1-phenyl-1-piperidinyl-ethene you would be left with, not an amphetamine.

It's entirely possible it's a transporter blocker of some sort though, like I said, it hasn't been intensively screened.
 
Like sekio says it doesn't really cleave at those positions, and while at first glance it looks kind of different than PCP they designed this to fit some pharmacophore ideal, by comparing different types of NMDA antagonist dissociatives like DXM, PCP, ketamine and dizolcipine. I read some of the scientific article on diphenidine which was interesting, I can recommend it...
Yes this is very much speculation: there are similarities to 3-MeO-PCP in my opinion and therefore indirectly PCP I guess, but I think everyone should strongly take into account that this compound may be quite dizolcipine-like, which I think suggests a certain 'challenge' in handling the material and state of mind it produces, perhaps even beyond PCP-like substances. Especially regarding tabula rasa like amnestic effects.
 
You must log in or register to reply here.
Top