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Misc diphenhydramine

Opiumoftheworld

Opiumoftheworld

Bluelighter
Joined
Mar 15, 2013
Messages
102
Does anyone actually like the high off if these pills ? Also how many Nytol 50mg is enough for a chill out but not crazy hallucinations ?
 
The minimum dosage seems to help a little with sleep if used only once in a while. Taking too much causes a nasty feeling and restless-legs.
I've heard trip-reports of people who were already on opiates and it had a mild synergistic effect.
 
Diphenhydramine can 'potentiate' the nod (if you will), of opiates and it also stops the itching, if you don't like them. But even these effects come at what I would consider therapeutic dosages of DPH.
 
Don't do it. It's the worst, most uncomfortable, high/trip ever. I hated it and I don't know anyone who ever tried it that even semi-liked it. It makes you full on delirious and comes with a really "crawl out of your skin" feeling of a body high.

It's horrible.
 
Opiumoftheworld said:
Also how many Nytol 50mg is enough for a chill out but not crazy hallucinations ?
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1-2 should make you drowsy, no amount will make you feel chilled out in a good way like a benzo or nice indica would. I recommend staying within the therapeutic dosing range, or being cautious when venturing outside of it (work your way up slowly, the body load can be kinda miserable).

This may just be me, but I found St. John's Wort (taking two 300mg capsules of your standard stuff from the pharmacy) potentiated 50mg DPH (for sleep) and made things really dreamy. This would be taking it near or concurrently with the antihistamine. I quickly gained tolerance to this effect. OTOH, they both have serotonergic effects, so it's rather iffy.

Check out the Big & Dandy Diphenhydramine thread.

Mr. Scagnettie said:
I hated it and I don't know anyone who ever tried it that even semi-liked it
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*Raises hand* I think anticholinergics are okay in sub-deliriant doses. Not pleasurable, but if you got some lying around and nothing else on hand...
 
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Some anti-histamines are nice actually , alimemazine , great with an opiate obviously but still nice withouth especially if your stuck somewhere like jail or a psych ward.

Tripenelamine would prolly be nice too , unfortunately nowadays it's only an ingredient in azarone bug stick where I live (it's the T in t's and blues)
 
I use DPH with my suboxone shot at night and it used to work really well with helping me get to sleep, it brought out the opiate a little more and I found it had an anxiolytic effect that I found quite nice. Unfortunately I am on a tolerance break because my nightly dose had jumped from 100mg to about 600mg, and I still wasn't finding any benefits after I upped my dose past 300mg. Hopefully a week off will bring my tolerance down :/
 
once, in my younger and dumber days, i took 250mgs of dimenhydrinate. i thought it was thoroughly unpleasant. and that was still a relatively low dose compared. i use dimenhydrinate in conjunction with cetirizin to mitigate the side-effects of strong opioids. but antihistamines are absolutely shit as recreational drugs.
 
Anti-histamines in general are fantastic medications for allergies and sometimes for sleep but are a miserable high. Its the kind of high where you have forget your high and think your delusions are real.
I suspect a portion of patients admitted to hospital with psychosis-like symptoms have been 'experimenting' with high dose anti-his.
Just out of interest, has anyone else experienced the disappearing/reappearing cigarette while on high dose anti-his?
 
I just take it for reasons everyone else said: sleep and opioid potentiation.

The high from DPH on its own fuckin sucks tho. As soon as u start feeling it, you just want it to be over with.
 
bunge said:
Just out of interest, has anyone else experienced the disappearing/reappearing cigarette while on high dose anti-his?
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I have heard of this being a common delusion on high doses of DPH, but more so with people who venture into datura. I can't remember the reasoning for it, but it was something like datura depletes your body of something that cigarettes can replenish. In other words, your body craves something and your mind incorporates it in your delusion. I'm sorry I can't explain it better, but thats the basic explanation I have read.
 
The mystery chemical is probably acetylcholine. Can't say I ever experienced this effect on datura though and I have always been an avid smoker. I did have a problem with reading imaginary books though. Also happens on other drugs sporadically so maybe it's just me.
 
Never Knows Best said:
Also, who's gone through enough data to draw such a conclusion?
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I'm sure little has been done in the way of actual scientific research, but it's a common enough occurrence that some speculation on it's cause has occurred.

Here is some reading on it, as well as a post from a different board, which I find interesting but can't say rather the information he states is 100% correct.

http://www.erowid.org/plants/datura/datura_info10.shtml

People tripping on datura often hallucinate that they are smoking cigarettes even if they have never smoked before.

Datura is anti-cholinergic, which means it slows down acetylcholine (an important neurotransmitter) and this is what causes you to hallucinate; Acetylcholine antagonism.

Tobacco, on the other hand, prevents the release of an enzyme that breaks down acetycholine, which makes it so there is more acetylcholine in your brain. EDIT: Nicotine actually agonizes acetylcholine receptors. I thought it was an AChEI (acetylcholine esterase inhibitor) but its actually on agonist, opposite of tropane and other datura alkaloids.

Interestingly enough, datura and tobacco are both in the solanaceae family. and they both affect the same neurotransmitter/receptosrs.

Since tobacco influences there to be more acetylcholine, it partly cancels out datura's effects.

It has been discovered that humans are able to detect what's in an object if they need it. For example, there was a man who was stranded at sea and he ate a ton of fish, but their wasn't enough protein in the fish, so he started craving the eyeballs because they had nutrients he needed in them.

I think our brains also know what tobacco does.

Since our brains 'know' the effects of tobacco, someone tripping on datura will crave cigarettes and hallucinate smoking them because their brain needs tobacco as an antidote.

This is just a highdea and theory so take it with a grain of salt
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Given all this, I imagine this 'phantom cigarette' phenomenon mainly happens because a person is use to the motions of retrieving and smoking a cigarette.
 
Thats all interesting stuff guys, thanks for sharing. I had a general idea of how the tropane alkaloids in datura work but didnt realize that tobacco is in the nightshade family. Ive also tried datura and did have the cigarette issue with that stuff (and the imaginary book hallucination plus shadow people, which are creepy as hell), ive also tried belladonna (i was a wild and impetuous youth.lol) but that was alot worse for side effects like dry mouth.
Anyway im going to stop there as im straying off point and i think the OP can gather what to expect with anti-cholinergic poisoning.
 
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