Opioids Dihydrocodeine, what's actually the deal

[4DQSAR]

DF118s or 'Dizzies' as they were popularly known used to quite regularly turn up on the streets. In the UK when detox got someone down to 10mg methadone/day they were swapped to 60mg DHC QID. It WORKED. People got clean.

But now, now a HR agency is judged on it's number of clients, not on the clients who got clean and so are no longer clients. So they just park people on juice or subs (for years) and go home and lie to themselves that they helped others.

 

[xyZedd]

Well my prescription is ready tomorrow for 100 30mg ir dhc so going to experiment, what I did find last month was plugging was mega strong and gave me the nod too early in the evening [like after work lol] so going to try a combo of both ,less plugged and more swallowed. Maybe 50 50 .I'll start low as my tolerance is way down .I'm going to try find the perfect way of administration. I just want a nice buzz not to fall asleep otherwise what's the point.genearly if I swallowed 5 and opened a cold beer I would find everything around me just nice ,no stress, very talkative like explaining the cricket to my wife who isn't the slightest bit interested .its been over 2 weeks since I last had any and it hasn't bothered me in the slightest .just as a matter of interest the feeling between plugging and oral is different with plugging being much stronger but leaving you more zombiefied

hey thanks for your posts I've found them very interesting. Any more experiences/updates to share re ideal dosages etc? I'm planning to start plugging my DHC script, I'm building tolerance and want to make what I have go further, and also hopefully avoid wrecking my liver! I get a script for 112 30mg tabs per month, I was actually meant to start tapering off hence the odd number of(112 reduced from 120) but the GP seems to have forgotten to follow up and reduce my prescription further

 

[4DQSAR]

I'm planning to start plugging my DHC script,

While DHC IS active in it's own right, the vast majority of it's opiate activity is still mediated by the far more active metabolite - dihydromorphine. So you really want DHC to undergo first-pass metabolism by the liver. In short, just swallow the pills.

As I mentioned, DHC was once a staple of opioid detoxification with DHC bridging the gap between low dose methadone and total cessation. But now people are just being parked on methadone and buprenorphine. So the fact that your clinician IS using dihydrocodine suggests they are pretty good at their job.

 

[lost weekend]

While DHC IS active in it's own right, the vast majority of it's opiate activity is still mediated by the far more active metabolite - dihydromorphine. So you really want DHC to undergo first-pass metabolism by the liver. In short, just swallow the pills.

As I mentioned, DHC was once a staple of opioid detoxification with DHC bridging the gap between low dose methadone and total cessation. But now people are just being parked on methadone and buprenorphine. So the fact that your clinician IS using dihydrocodine suggests they are pretty good at their job.

Hi I know you know a vast amount of knowledge about how certain drugs get metabolised in the body ,more than any other threads I've read .is there a reason plugging dhc can provide positive effects with less ingredients. Thanks

 

[lost weekend]

Sorry have a vast amount of knowledge...

 

[4DQSAR]

I've read .is there a reason plugging dhc can provide positive effects with less ingredients. Thanks

Hey - I'm not infallible. I'm aware that for a couple of decades the only form of oxycodone in the UK was a suppositary because it's only in the last decade that researcher were able to demonstrate that the 10% of the oxycodone being metabolized to oxymorphone (ten times more potent) was actually responsible for at least half the analgesic activity.

If DHC undegoes a different metabolic pathway if consumed in that manner, I would be fascinated to learn about it.

But be aware that the references used by Wikipedia in regards to metabolism of both oxycodone and DHC are decades old. Both of them assert that while the metabolites ARE formed, they do not contribute to the analgesic effects. As previously mentioned, in the case of oxycodone it took a decade of publications to demonstrate quite the opposite. Sadly, few people are still researching DHC. But be aware that science is a process, not a set of facts.

As a child I was taught that the neutrino was a massless particle. Now, with advances in research, we now believe that it not only has mass but in fact it has three different masses depending on what 'flavour' it's demonstrating at the time of detection. That's why a couple of decades ago I threw away my extensive collection of academic papers. I kept finding that later research using better methods produced quite different data.

 

[lost weekend]

Hey - I'm not infallible. I'm aware that for a couple of decades the only form of oxycodone in the UK was a suppositary because it's only in the last decade that researcher were able to demonstrate that the 10% of the oxycodone being metabolized to oxymorphone (ten times more potent) was actually responsible for at least half the analgesic activity.

If DHC undegoes a different metabolic pathway if consumed in that manner, I would be fascinated to learn about it.

But be aware that the references used by Wikipedia in regards to metabolism of both oxycodone and DHC are decades old. Both of them assert that while the metabolites ARE formed, they do not contribute to the analgesic effects. As previously mentioned, in the case of oxycodone it took a decade of publications to demonstrate quite the opposite. Sadly, few people are still researching DHC. But be aware that science is a process, not a set of facts.

As a child I was taught that the neutrino was a massless particle. Now, with advances in research, we now believe that it not only has mass but in fact it has three different masses depending on what 'flavour' it's demonstrating at the time of detection. That's why a couple of decades ago I threw away my extensive collection of academic papers. I kept finding that later research using better methods produced quite different data.

All I can say in dumbed down English is plugging did work with me but found it real heavy ,kind of like it was obvious was on something, but if i split the administration of dose I'd get best of both worlds .

 

[lost weekend]

If there is such a thing "best of both worlds "
I doubt it

 

[4DQSAR]

Well, obviously if you plug DHC, it's going to have almost 100% bioavailability and as I mentioned, it was discovered many years ago that unlike codeine, DHC IS active in it's own right, but it does appear that whoever edits the BNF and indeed whoever decides which formulations of which medications are appropriate do appear to have access to up-to-date information.

I'm gutted I couldn't find you a more recent paper on the activity of DHC because it is entirely possible that other metabolites are involved. I note that some papers mention hydrocodone being a metabolite but all of them are from the era when the metabolites were not considered to be active.

At the end of the day, the only thing that REALLY matters to you is that it WORKS. I'm glad it does as I think DHC is a valuable tool in detoxification.