Dihydrocodeine excretion in urine

[permastoned]

I'm confused, this article I have read on the excretion of dihydrocodeine says that between 32-108 % equivalent of the dose is recovered in the urine.

I have decided that this can mean 1 of 2 things:

1: Because it says 'equivalent', and some of the dihydrocodeine is metabolised to dihydromorphine, it means that if the contents of the urine were to be readministered to the individual, the response would be greater than the original response due to the presence of the stronger opioid.

2: Alternatively, it is a typo or I am an idiot for not thinking of some other reason why it may say 108%.

Abstract

Urinary metabolic pattern after the therapeutic peroral dose of dihydrocodeine tartrate to six human volunteers has been explored. Using the GC–MS analytical method, we have found that the major part of the dose administered is eliminated via urine within the first 24 h. However, the analytical monitoring of dihydrocodeine and its metabolites in urine was still possible 72 h after the dose was administered. The dihydrocodeine equivalent amounts excreted in urine in 72 h ranged between 32 and 108% of the dose, on average 62% in all individuals. The major metabolite excreted into urine was a 6-conjugate of dihydrocodeine, then in a lesser amount a 6-conjugate of nordihydrocodeine (both conjugated to approximately 65%). The O-demethylated metabolite dihydromorphine was of a minor amount and was 3,6-conjugated in 85%. Traces of nordihydromorphine and hydrocodone were confirmed as other metabolites of dihydrocodeine in our study. This information can be useful in interpretation of toxicological findings in forensic practice.

http://www.sciencedirect.com/scienc...serid=10&md5=27deb2b76a5f82f95fbe363d04055cd0

Cheers!

 

[permastoned]

No one knows??

 

[wreckhead]

Injecting chocolate and distilling urine. This forum is so weird...

 

[permastoned]

Who said I was gonna distill it... I love me a
Good dose of urea.

 

[Sturnam]

Well, I don't know if you have access to the full article, but they have an awesome table at the end detailing everything. Basically, the metabolism GREATLY varies between people (evidenced by the 32-108% of metabolites excreted).

This may be due to the same reasons that people have varying reactions to codeine, and it seems like some people may metabolize DHC to the hydromorphine derivates more (but it may not be statistically significant in any way).

But, from the table, in terms of DHC equivalence:
The lowest person (28% equivalence) left 23% unchanged (DHC), dihydromorphine with 1.5%, nordihydrocodeine 3.4%, and nordihydromorphine .5%.
The highest (108% equivalence) had 78% unchanged (DHC), dihydromorphine with almost 8%, nordihydrocodeine with 16.2%, and nordihydromorphine with 5%.

 

[permastoned]

Thanks Sturnam! Forgot to recheck this thread. I hadn't read the full article at the time but I have now. Very cool table indeed! TIme to go drink some urine!

 

[permastoned]

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