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Differences Between Mushrooms and all other Psychedelics

7

777xog

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Aug 16, 2010
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I wonder if anyone can comment on what exactly makes mushrooms 'different'.
(whether it's in pharmacological terms, or anecdotal experiences).

Case 1 - I have a friend who is prescribed certain medications, namely anti-anxiety benzos, anti-depressants, and an anti-psychotic I believe. (for bi-polar disorder). At times, she chooses to trip. Her experience has been that the synthetic phenethylamines and tryptamines seem to be more likely to interact with her medications, whereas she has never had any problem of that sort with mushrooms.

Case 2 - A friend mentioned to me that normally when he trips, he always has the urge to chain smoke cigarettes. The only exception is with mushrooms - he has no urges.

I wonder - is there some key pharmacological difference when it comes to mushrooms?
Is there any rational reason to suggest why the psilocin and other active chemicals in mushrooms are less likely to interact with medications?
Has anyone else noticed these kinds of differences?
 
There is definitely a lot of truth to this. Mushrooms make me more likely to have an introspective trip, and more likely to become in tune with nature and my positive side.
When I take acid it's for the ride, for mushrooms it's more for the mindset
 
well obviously all the psychedelics are widely different chemicals. however there are some that are very close to psilocybin etc.

but as far as the trip goes yes shrooms are completely different than acid, DMT,2cx, salvia, weed, etc the popular psychs
 
After hearing David Nichols' lecture on psychedelic neuropharmacology I came to believe that there is, in fact, a difference between home-grown shrooms, wild shooms and synthetic psilocobyn. It has to do with various shapes and electromagnetic properties of resulting molecules.
 
Can't think of a psych that figuratively beats your ass like mushrooms do. Mushrooms also have this organic feel that only LSD comes close to.
 
Toast said it right.

The often present restlessness and anxious tension I get from RC's and synthetics make me chain smoke. Mushrooms feel smooth and natural, always puts me in a sort of prohealth mindset. Where smoking tailored cigarettes seems irrelevant and fruitless. There's something different about rolling your on ciggies with fresh tobacco while tripping though. I like it.
 
Shee-un said:
After hearing David Nichols' lecture on psychedelic neuropharmacology I came to believe that there is, in fact, a difference between home-grown shrooms, wild shooms and synthetic psilocobyn. It has to do with various shapes and electromagnetic properties of resulting molecules.
Click to expand...

A difference between wild VS homegrown mushrooms???
I would definitely be interested to hear that lecture. Got a link?

I also noticed that mushrooms have a very "smooth" comeup. I once wrote a trip report describing them as a "name brand" psychedelic.
But they can be oh so mindfucky compared to other things.

I once took 18mg of 4-ACO-DMT; what I experienced was a very light, shallow trip that paled in comparison to even a supposedly modest 1.6 grams of mushrooms.
(I haven't had a chance to try 4-ACO-DMT since then, but it's hard to imagine even a significantly higher 4-ACO-DMT dose could come close to mimicking mushrooms in the same qualitative way)
 
Mushrooms definitely are unique.... They're the only psychedelic that make me totally content and peaceful at any dose, rather than always wanting to push higher. It's really nice. My best guess has always been that at least part of the reason is because psilocin is like the only psychedelic that doesn't interact with dopamine receptors. (Aside from RC 4-HO-tryptamines most likely.) Lysergamides and phenethylamines hit them, and even DMT activates at least D1. Psilocin stays away from that addictive brain circuit... just keeps you cruising on that happy serotonin buzz. <3
 
Mushrooms contain 4-ho-DMT and esters thereof. There is no reason why subjective effects would be any different to a synthetic mixture of the same compounds. 4-aco-DMT (an ester of 4-ho-DMT) should be extremely close in action.

Nobody has ever provided any evidence to suggest that natural vs synthetic makes any difference at all.
 
Anon0631 said:
Mushrooms contain 4-ho-DMT and esters thereof. There is no reason why subjective effects would be any different to a synthetic mixture of the same compounds. 4-aco-DMT (an ester of 4-ho-DMT) should be extremely close in action.

Nobody has ever provided any evidence to suggest that natural vs synthetic makes any difference at all.
Click to expand...

Agreed. I think there's a lot of prejudice surrounding these topics. The whole "synthetic vs. natural" debate is, for me, a kind of a prejudice. There's way too many RCs to make any generalizations of how they act.

Subjective differences, of course. This is why there are personal preferences. If someone feels more at ease ingesting "natural" compounds, they might as well enjoy the experience more. But that's about it. I don't think shrooms are substantially different, or substantially similar, for that matter, to any group of psychedelics.
 
Studies have indicated 4HO-DMT can interfere with addictions and has antidepressant attributes. 4ACO-DMT, 4ACO MiPT, 4HO MET are all fairly similar to 4HO-DMT in my experience. Duration, intensity, visuals etc are similar but subtle differences are evident especially when comparing duration and dosage. DMT itself has broken many addictions and resolved psychological issues such as depression or PTSD for some users. Not all people react the same and some people have a negative experience with these substances despite setting/sitter etc. However even negative experiences often leave the user feeling more alive and psychologically stronger after the ordeal has passed.

Most of the substances in TIHKAL are wonderful substances but each individual may have a different subjective experience, kind of like allergies if you will, some people have allergies to certain things while others don't. A bad subjective experience (allergy) to one person may be a profound and magical experience to another (no allergy). However to another closely related compound the reverse may be true or both have good subjective experiences or bad. One tryptamine I dislike and even find dangerous is 5 meo-mipt. I experienced heart palpitations that lasted for hours for minimal positive subjective effects this is my "allergy". Other users report wonderful effects from this substance but it seems there are more negative experiences from this substance than positive.

PEA's are also a wonderful group of substances. The main difference I find is that psychedelic PEA's often vaso-constrict and raise heart rate core body temperature although tryptamines also do this I personally find PEA's do this more frequently per substance. Again every person is different!

When consuming mushrooms in the past basically a large plastic shopping bag is filled and this is added to a large pot simmering with just enough water to cover the shrooms. The shrooms are crushed using a potato masher and the resulting goo is simmered and reduced. This is then strained and the solids compressed until as much liquid as possible is removed and added to the strained fluid. This is further reduced by simmering until around 700 ml or so of dense black syrup remains. This is cooled. The liquid/syrup is poured with an equal amount of lime cooler into a shot glass 50/50 and downed. 3-4 shots have you hammered 8-9 will have you tearing the metal divider between lino and carpet clean out of the floor while convinced a swarm of spiders are emerging from said metal divider... tread with caution.
 
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I think people aren't understanding this right...

Shrooms have a bit more to them than just solely psilocin as stated above. All these tryptamines are like taking an LSD analogue like AL-LAD and expecting it to be LSD. If you want the full experience, get everything that's involved, don't try and make shortcuts. It's the same way people even discuss differences in strains.

From other psychedelics though shrooms are quite good, bit nauseating for some but the natural euphoria it creates is enjoyed by many and since it is quite a more clearer/open headspace than acid in lower/common doses people tend to find it a bit easier. High doses can be ridiculous and you can push it very far with mushrooms, they have a great duration too about 6 hours which makes them more convenient if you find yourself getting strung out on longer psychedelics like acid towards the end and if you're in the deep end and don't want to spend all day there. In comparison to 2cs, much more in depth introspective experience, apart from a select few most 2cs are seen as much more recreational. If you are looking psychedelic therapy this is the option or LSD, not 2cs. You may however, if experienced with the 2cs feel things aren't happening enough visually, but keep in mind it's easier to get to high doses with powder than shrooms so just dose higher and get some senses blending 8-)

There's a reason people have been eating these fuckers for thousands/millons? of years. If you can't handle the shrooms 4-ACO-DMT or psilocin itself are probably the closest comparisons out of Tihkal's list, but as said above it's likely you need a combination of the actual contents of shroom. Those two are perfectly capable of providing strong rewarding psychedelic experiences though.
 
im not a big psych person, but i have loads of experience with shrooms. seems like for a few years they were beyond popular around here. cant say prices and all, but lets just say 7gs of amazing boomers cost less than an 8th of good buds. friend of mine has an amzing connec right from a grower, and she would arrange dozens of lbs at a time. after binging on those for a few months i can say they are by far the most easy feeling psych. not crazy deep and introspective, enough visuals to be fun, light body load except for some stomach uneasiness. im sure if you weere to take like 10gs of them it would be pretty intense, but over all they are just a good fun organic feeling trip.
 
Anon0631 said:
Mushrooms contain 4-ho-DMT and esters thereof. There is no reason why subjective effects would be any different to a synthetic mixture of the same compounds. 4-aco-DMT (an ester of 4-ho-DMT) should be extremely close in action.
Click to expand...

Main difference I find in taking mushrooms and taking powders like 4-dmt is the length of time it takes to come up. With mushrooms it usually takes 30-60 minutes to come up because you have to digest the mushroom whereas with powder it often hits you almost straight away. That seems to alter the nature of the trip - makes it smoother and gives you more time to orient yourself.

Psilocybin and oral DMT which it's very closely related to seem to be the kings of psychedelics. They simply work as good, or better, on every level than any other psychedelic - whether it's cathartic emotional experiences, laughing, bodyhigh, visuals, psilocybin has it all.
 
xTalK said:
I think people aren't understanding this right...

Shrooms have a bit more to them than just solely psilocin as stated above. All these tryptamines are like taking an LSD analogue like AL-LAD and expecting it to be LSD. If you want the full experience, get everything that's involved, don't try and make shortcuts. It's the same way people even discuss differences in strains.

From other psychedelics though shrooms are quite good, bit nauseating for some but the natural euphoria it creates is enjoyed by many and since it is quite a more clearer/open headspace than acid in lower/common doses people tend to find it a bit easier. High doses can be ridiculous and you can push it very far with mushrooms, they have a great duration too about 6 hours which makes them more convenient if you find yourself getting strung out on longer psychedelics like acid towards the end and if you're in the deep end and don't want to spend all day there. In comparison to 2cs, much more in depth introspective experience, apart from a select few most 2cs are seen as much more recreational. If you are looking psychedelic therapy this is the option or LSD, not 2cs. You may however, if experienced with the 2cs feel things aren't happening enough visually, but keep in mind it's easier to get to high doses with powder than shrooms so just dose higher and get some senses blending 8-)

There's a reason people have been eating these fuckers for thousands/millons? of years. If you can't handle the shrooms 4-ACO-DMT or psilocin itself are probably the closest comparisons out of Tihkal's list, but as said above it's likely you need a combination of the actual contents of shroom. Those two are perfectly capable of providing strong rewarding psychedelic experiences though.
Click to expand...

Different strains of shrooms can provide different experiences. Gold Tops or Golden teachers can provide a very profound deep introspective experience while blue meanies I find much more stimulating. Philosophers stones are a very mild experience as are Mexican truffles, Cambodian shrooms are more intense with more visuals etc. There are literally hundreds of different strains and most people have only experienced 3-4 different types. Adding a mushroom picking collective ie from different area's different strains and 5-6 people out picking you can get an altogether different "trip" from the combined brew. Some grow in woodlands, some grow in fields (usually in cattle shit) others grow in all kinds of conditions (ie compost pile). It's important to note shrooms may be contaminated by other microbes and become toxic, basically bacteria or other fungi out competing the shroom and killing/infecting it resulting in possible toxicity. Picking wild shrooms you MUST KNOW WHAT YOUR DOING!

I lived in a place where I only had to walk out my front gate at certain times of the year there were psychedelic mushrooms EVERYWHERE. We'd collect garbage bags full and basically binge on mushrooms for days on end. Multiple strains as well. This is because spoors spread and are taken into the very high altitude of or planets atmosphere (can't recall the name) and prevailing winds spread them all about. Get the right conditions, food source and climate then boom psychedelic mushrooms like a carpet. By simply combining several different strains you can get a profoundly different "trip". Then by basically extracting the alkaloid content and concentrating it you end up with VERY POTENT LIQUID.

As for the analogues all are different. Never expect say ALD 52 (magic) to be LSD (meh) or aMT (wild) to be 2cb (fun). Also DOx vs LSD totally different drugs with different half life and subjective effects. 2ce can be a profound introspective and spiritual experience while 2ci is more of a party drug with a long (up to 16 hour) half life, which can end up being annoying. DOx's can be profound spiritual experiences or more of a party drug depending entirely on the individual. I have not come across ALD 52 since 1994-95 although it was sold as LSD it was a more beautiful experience for me personally than LSD which I guess I've done a bit to much of so for me it's kind of... well boring, but that's just my own personal subjective experience and many would disagree as their subjective experience differs.

Snorting synthetics or DMT snuff brings on the subjective experience far more rapidly than oral consumption as does smoking DMT. Also combining different synthetics can produce trips of far more complexity than DMT or shrooms alone. I combined 25-30 mg TMA2 with 1.2 mg 25c Nbome for the most profound visuals, also the visuals created combining 70-80 mg MXE with 40 mg 2ci. Yage (DMT and an MAOI) can give amazing visions and introspective experiences as well as masses of vomiting/purging. These heavy psychedelic experiences can cause one to fear they are dying/ being reborn/ spiritual awakening or simply be a purgative ordeal that leaves the subject bathed in an afterglow and renewed focus and positive outlook simply by surviving the ordeal.

Bromodragonfly has to be the one drug that almost pushed me to psychosis and of just 1 tab... I've done tones of DOx's, 2cbFly, 2c's etc but that bromoshit was just manic and out of control. Anyway hope I got close to what the original post was asking about or at least gave some food for thought to all you perspective trippers! :)
 
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I must be in the minority that personally dislikes mushrooms.

The only mushrooms that ever were consistently good with me was a batch of penis envy mushrooms and even then, too much gave me that same sick and poisoned feeling that all other mushrooms gave me at any dose that didn't immediately obliterate my conscious mind.

There is something special about them but I far prefer mescaline to mushrooms. Other than the upset stomach at the ramp up, the body is much happier with me when I do mescaline than when I do shrooms and mescaline is a much more spiritual connection than psilocin as well. Psilocin is very much a mind fuck for me and not in a clear way either usually so I only ever really got a spiritual experience out of mushrooms a few times - 4-HO-DiPT, 4-HO-MiPT, and 4-HO-MET were all much better than psilocin to me. 4-HO-DiPT had the visuals, the body high, and the spiritual, 4-HO-MiPT had the body high and the spiritual and 4-HO-MET had the visuals and the body high. Psilocin paled in comparison with the exception of a 6g penis envy trip and the first time when I chugged a smoothie that had a 1/4 in it and got so messed up it rivaled DMT for OEVs.
 
Heat (cooking on a low heat for a while) or drying the shrooms reduces the toxic feel of eating what is basically a poison. Eating raw shrooms is very nauseating and slimy. Simmering and reduction seems to reduce the nausea also proper drying seems to reduce the nausea. Alternatively you could try and extract the alkaloids although this is a difficult process. The different synthetic derivatives are fun and often remove the toxic load that users experience while consuming mushrooms. Also I do not understand the weight thing? I'm used to making a brew with literally hundreds of individual mushrooms in the brew. Except a trip to Holland and a "smart shop" I and those I used to make brews with never weighed them there were to many mushrooms. Also freezing mushrooms is good for times when they are not around naturally or grow them in compost etc (chuck a few handfuls of mushroom caps onto a well established compost pile and keep moist etc).

I fucking love synthetic analogues both tryptamine and PEA's, well 95% of them anyway. There are a couple (like 5 meo mipt) that I won't be repeating. Mescaline even well extracted 90 odd percent pure makes me puke but after a good purge it's one of the greatest natural psychedelics along with DMT, Shrooms, ibogaine etc. One spirit plant I would never use is Datura and it's relatives. It was used as a form of birth control among my ancestors.
 
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I think for me, my chemistry just doesn't like psilocin/psilocybin. I had the same horribly toxic feeling from known exceptional 4-AcO-DMT and I had it every single one of the 5 times that I used it before giving up on it.

And yeah mescaline will make you toss your cookies but after that its smooth sailing into the center of the universe.

I've had mushroom tea, mushroom smoothie, and ate them orally, all dried. The mushroom tea was nice and mellow and we added some molly to it for a nice mild day trip, the smoothie blew my mind, but every time I eat themm its like i just ingested poison. Very odd. I suppose I could have a mushroom allergy.
 
Mushrooms have those chemicals as a natural defense mechanism to STOP THINGS EATING THEM. Don't worry I get nausea and I suspect most people do. I think it has something to do with the area of the brain responsible for nausea etc that is triggered by the chemicals themselves maybe 5HTP receptors have something to do with gag reflex I can't recall anyway I'm off to the land of zzzzz.....
 
With me, I have NEVER gotten nauseous from shrooms... that's the strange thing. The way they make me feel is like my whole body hurts, I get tachycardia, I get really hot, I get dehydrated... its the oddest thing because you would think I'd get nauseous too but I've even tried making myself throw up on them before at the suggestion of a friend who said that purging would make me trip harder but always makes him not feel poisoned anymore and they kill my gag reflex - I spent 10 minutes trying to get myself to gag and couldn't do it long enough to even feel anything coming up from my stomach. I've tried with and without food, I've tried with and without alcohol, I've taken benzos to try to smooth it out. The only success I ever had was taking an extended release morphine before my shrooms and letting that kick in before eating them. That was pleasant but I forgot most of the trip because I was nodding (I have no opiate tolerance, never use them)
 
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