I wondered about this earlier today, are some of the Pihkal entries perhaps colored by a tolerance to psychedelics? I thought of this when considering 2c-n.. It would seem Shulgin didn't mention much visual activity at all, where the only report outside of Pihkal I read details full blown Childhood memory recall imagery.. I imagine the dosages listed in Pihkal are not only from Sasha's first hand account.. So maybe he lists his own as well as those of others? I'm unsure if I can go by the Pihkal dosages now..
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Did Sasha Shulgin have a tolerance to PEA's?
- Thread starter QuasiModo
- Start date
Well you might be right but the guy is a scientist he didn't get high every weekend. And as you mentioned out was based on existence of others who may or may not of had tolerence.
P.s have you ever noticed he sounds like jimmy from south park
P.s have you ever noticed he sounds like jimmy from south park
Help?!?!
Bluelighter
It would not be scientific at all to simply test a new compound on one person....he had his own research group and often gave his creations to multiple people to receive multiple sets of feedback similar to other experiments. I'm sure at certain times he had some sort of tolerance as I don't believe you can give me proven data that shows when regulation of receptors is complete, for all we know as well different receptors take different amounts of time/etc. Back then even less was known but Shulgin always approached his experiments I believe with tolerance and safety in mind. I believe he literally outlines his set schedules/procedures for testing the chemicals. Also why would you even follow Pihkal anyway...unless your testing an extensively rare one that is?
Edit: Also, its already known that T/PIHKAL aren't bibles for doses or information. Since thousands of people have sampled the inventions the curves have been fine tuned and I believe even in some cases outright changed a bit. I know for a fact MDA and the duration was off, but most people probably know that, only one I could think off of the top of my head really(maybe 4-HO-MET since its only 10-20 and IMO theres many people who don't find it highly active until 30-40 mgs).
Edit: Also, its already known that T/PIHKAL aren't bibles for doses or information. Since thousands of people have sampled the inventions the curves have been fine tuned and I believe even in some cases outright changed a bit. I know for a fact MDA and the duration was off, but most people probably know that, only one I could think off of the top of my head really(maybe 4-HO-MET since its only 10-20 and IMO theres many people who don't find it highly active until 30-40 mgs).
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Transcendence
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I doubt tolerance has anything to do with it. A lot of people seem to miss the fact that most of the experiences reported in PIHKAL and TIHKAL are not Shulgin's. Although I assume he has personally sampled all or most of the compounds, it's likely that several weeks at least have passed between the time he samples each one. That isn't close enough to retain any tolerance.
Maybe he didn't get high every weekend, but what does being a scientist have to do with it =p
Maybe he didn't get high every weekend, but what does being a scientist have to do with it =p
well, i saw a video of the shulgins, and anne estimated she'd taken 2000 trips and alexander 4000 trips.
anyway i think simply because of the quantity of drugs he has taken throughout his life he is bound to have a higher tolerance, then say someone who has never tripped.
yes i think the fact he is still alive and sane after not only taking but having created so many powerful compounds, testifies that his meticulous qualities paid off... !
anyway i think simply because of the quantity of drugs he has taken throughout his life he is bound to have a higher tolerance, then say someone who has never tripped.
yes i think the fact he is still alive and sane after not only taking but having created so many powerful compounds, testifies that his meticulous qualities paid off... !
PippUK
Bluelighter
I don't know about Shulgin's tolerance. As mentioned above, many of the reports P/Tihkal were those of his friends and associates.
I have noted that the dosages quoted in the books were slightly low sometimes, but I had imagined that to be an effort towards harm reduction.
For example, the report with the highest dosage for 2ct7 quotes 30mg. Personally speaking, for me that is at the upper end of a low dose.
Horses for courses. Shulgin was probably wary of being careless about handing higher doses of novel compounds to his chums. Even then, if I remember rightly, they had one or two sticky moments.
As has been said already, he is probably more clued up about tolerance than most people. But over a lifetime it must surely have some effect.
Peace - Pipp
I have noted that the dosages quoted in the books were slightly low sometimes, but I had imagined that to be an effort towards harm reduction.
For example, the report with the highest dosage for 2ct7 quotes 30mg. Personally speaking, for me that is at the upper end of a low dose.
Horses for courses. Shulgin was probably wary of being careless about handing higher doses of novel compounds to his chums. Even then, if I remember rightly, they had one or two sticky moments.
As has been said already, he is probably more clued up about tolerance than most people. But over a lifetime it must surely have some effect.
Peace - Pipp
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IamMe90
Bluelighter
Clearly those testing did not have a very high tolerance given the extremely low suggested dose ranges for the chemicals. 40mg upper for 2c-c? Are you kidding me?
shishigami
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Lots of the doses and experiences described in PiHKAL and TiHKAL appear to be more therapeutic than full blown psychedelic. Something I always consider.
Jesusgreen
Bluelight Crew
I believe most of the experiences listed in TiHKaL and PiHKaL are other peoples' experiences, I've actually found some of the original messages containing some of the experiences on extremely old bulletin boards etc. I suspect the Shulgins probably do have quite a high tolerance due to repeated experiences, and this is likely why most of the experiences listed are other peoples, so that they didn't encourage ridiculously high doses - and also to give a more balanced view rather than just their own experiences 
greenmeanies
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Also remember that Shulgin had a very specific goal in mind when he was searching through these analogs--- if a bad ratio of side effects or stimulation was noticed, the compound was shelved and not pursued. Presumably several of PIHKAL's "no effect" statements are actually "no positive effect that we were looking for" and might be OK as stimulants or antidepressants, but not "WOW great mescaline analog"