I first started using psychedelics right after turning 15, so like entheo said, it's impossible to know how much they have changed me as a person.
I started smoking weed one month before turning 15, and only 3 months later I took shrooms for my first time. Shrooms were the second drug that I had ever used, I hadn't even tried tobacco or alcohol at that point. That trip remains one of the most profound moments of my life. Afterwards I became infatuated with psychoactives. If it weren't for that trip I don't know if I would still have the "Gotta Catch 'em all" mindset that I do now. Ever since then I have been very passionate about psychoactives, using a good chunk of my free time to expand my knowledge of different drugs, and also experiencing them.
Then only drug that I know had a lasting effect is DXM. After having multiple trips where I was convinced that I was dying I am no longer afraid of death. I used to be absolutely terrified of death, not knowing what comes after life. After fighting my 'death' in each of these trips, I would always come out of the fight with a beautiful acceptance of death. Unfortunately that would usually only last until I got to sleep that night.
The trip that is really responsible for easing my fear of death was actually a pretty funny one. I don't want to get too off topic, so here's a really short version of it. I was on at least 400mg of DXM (can't remember the dose exactly) and I had to use the bathroom. I went to the bathroom, went back to my room and started playing video games. 20 minutes later I hear water falling and I stumble back into the bathroom. I had forgotten to turn the faucet off in our clogged sink. It overflowed, made waterfalls out of the open drawers, and left a HUGE puddle over the whole bathroom. I was cleaning it up and noticed that I got my sisters hair dryer wet (which had been patched up with electrical tape). I didn't think anything of it until I got back into the room. I convinced myself that she would plug the wet hair dryer in and be electrocuted to death. The terrible image played through my head, as well as the aftermath. The whole family including myself mourning her death. After mourning for awhile I was able to accept my sisters 'death'. After that I thought about what if I plugged it in and died? So there I go, behind my eyelids, plugging it in and getting electrocuted. This was terrifying to me. The scene played over a few more times until it got to the point where I was able to witness how the world would be if I passed away. The world was unchanged, except for my family. I got to witness the mourn my death. It was devastating to them, but eventually they were able to move on and keep living their lives. In a way I was able to mourn my own death through them. Again I had this beautiful acceptance of death. I opened my eyes and went back to the bathroom, it was either me or my sister who would be killed. I picked up the cord, took two deep breaths, and plugged it in convinced that it was going to kill me. Ever since then I have not felt a twinge of fear when I think about my death, and for that I am very thankful.
Sorry, that was pretty off topic, The 2-FA must have kicked in