• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Diclofensine 4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

B.L.T.C.

B.L.T.C.

Greenlighter
Joined
Jun 16, 2010
Messages
2
Location
Berlusconia
Hi there, i've been lurking here for about a year... now it's time for my first post.
If there's already something 'bout this one or if it is in the wrong section feel free to delete.

I saw a vendor selling this chem:

Names: Diclofensine; Ro 8-4650; 4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

CAS: 67165-56-4

Assay: >98.5%

Appearance: A fine powder with off-white/pink colouration.

Diclofensine - Wikipedia, the free encyclopedia

As wiki states it's been tested as antidepressant, i'm asking myself what would be the effects if used recreationally...

Any info that's not wiki on this one? is there a report of recreational use? what about the abuse potential?

btw very pleased to make part of this site now... BL rocks, and rolls =D
 
ok, now there's another thread about diclofensine on PD... :\ assumed you preferred that one we can close this, sorry for double posting.
 
i posted the one in PD, but haven't really gotten much useful info over there yet. I don't really know much about THIQ's.

I was actually about to post over here with regards to potential toxicity, metabolism, etc...

I'd imagine this would get demethylated first, or the methoxy might go first... just looking at this molecule feels kind of strange as its so different from most things i usually read about. Also, how effective a stimulant would this even be?
 
There's only one way to find out how good it would be, however my gut is telling me that it'll suck.

Though it apparently had enough abuse potential to be dropped from development, which is a good sign.

As for how wierd it looks....

Recall that 3,4-dichloropyrovalerone was the most powerful of the pyrovalerone monoamine RI's - MDPV was chosen as an RC because it was felt to be one of the safest powerful ones.

Draw 3,4-dichlorophenethylamine, in the way we normally would draw it, and then fill in the rest of the crap above it. I think that's the way you want to look at this one....
 
Alternatively they dropped it because of the fallout from nomifensine.
 
vecktor said:
Alternatively they dropped it because of the fallout from nomifensine.
Click to expand...

Ah... so it would also put the user's kidney's and livers at risk? Would these risks be only be a concern for chronic users or it's best to stay away that compound altogether?
 
Wikipedia cites a source in a french journal, saying that the likely source of toxicity was the anilino moiety (which is not present in diclofensine) but i'm not sure i'd trust that.

Diclofensine looks like it was dropped BEFORE nomifensine was dropped, thoguh you'd have to look more closely at the timelines to be sure - could also have happened at the same time, with the company deeming it guilty by structural similarity.
 
thanks for the info, i've read some abstracts, but my school doesn't have access to most of the full articles for some reason. At least there's a fair amount of literature about this one.
 
yeah abuse potential for unmarketed anti-depressants might just translate as uptitrating doses or gets people slightly TOO happy, too stimulated. doesn't necessarily translate as fun stimulant.

Molecule doesn't look too far off sertraline in structure. :\
 
ahem - has anyone else read this?

At 0.32 mg/kg/injection, diclofensine maintained a cyclic pattern of intake. In contrast, this cyclic pattern of drug intake was seen in only one baboon with nomifensine and in none of the baboons tested with bupropion. Cyclic patterns of intake have been reported when high doses of stimulant drugs have been tested under this procedure previously (Griffiths et al. 1976), in procedures allowing unlimited access to stimulant drugs (Pickens and Harris 1968; Deneau et al. 1969), and in stimulant abusers in their natural environment (Griffith 1966; Kramer et al. 1967). It is possible that if higher doses of nomifensine and bupropion were tested that cycling might have been detected, since cycling appears to be more likely as dose is increased (Griffiths et al. 1976). One should note that the "bizarre and stereotyped" behavior often seen following administration of high doses of stimulants was beginning to emerge at the highest dose of diclofensine tested, which occasionally led to the premature termination of a test sequence. Such behavior was also occasionally noted during nomifensine self administration, but did not lead to the premature termination of any test sequences.
Click to expand...

could someone explain exactly what they mean by cyclic intake and how this differs from repeated self administration, and while your at it, what is meant by "'bizarre and stereotyped behaviors'" is this synonymous with amphetamine psychosis?

EDIT: also considering that high dose bupropion (500mg+) has made me more psychotic than any stimulant except low dose MDPV (never made it to medium or high dose as said pro-psychotic side effects were too severe) its a bit disconcerting that diclofensine produced behaviors so "'bizarre'" that the tests had to be terminated - then again this still does not mean it will not be useful at low doses - like bupropion
 
Last edited:
This one is also a very interesting TRI that was almost accidentally discovered whikl researching a sertraline analogue. I posted this many months ago but didnt receive much attention back then.

Tametraline

At the middle bottom of the page there is table listing the possible conjugations and the Ki for many receptor.

Have a look...
 
Someone in PD said that there is a study where this stuff turned rats gay. Anyone has a link? Tried many searches but couldn't find anything. Naturally, I am very interested =D.
 
Up to 150mg was used in those clinical trials, will probably start around that dose and work my way up from there.

Had a large drug binge this weekend, so dunno wheter il bioassay this tomorrow, but i'm gonna be testing this one soon.
 
MeDieViL said:
Up to 150mg was used in those clinical trials, will probably start around that dose and work my way up from there.

Had a large drug binge this weekend, so dunno wheter il bioassay this tomorrow, but i'm gonna be testing this one soon.
Click to expand...

let us know how it goes, eh? been really curious about this one myself.
 
Since you copied and pasted the info directly from the vendor website one can easily find the vendor. Just sayin'.

(I'm 99% sure I have the same site as you in fact!)


p.s. if anyone decides to try it do tell us the results! I'd be interested and might even buy myself a few grams. :p
 
Allergy test without trouble, just ingested 150mg, will keep yall updated.

2.00: Ingested 150 mg
2.30: Starting to feel some slight stimulation, nothing special yet.
2.45: Slight increase in heartbeat
3.00: Feeling some headrushes, feels stimulating, quite nice altough still really mild
3.30: still feel the same, really mild and kinda boring.
 
Last edited:
The 2 chlorine atoms on the benzene ring don't look too healthy. One good thing is that people won't be making this in a kitchen pot any time soon lol!
 
You must log in or register to reply here.
Top