Diazepam and other benzo effects on nicotine and cytochrome P450

[hashishashish]

So apparently benzodiazepines effect are reduced but cigarette smoke which induces cytochrome P450 which metabolises them, now there evidence this is true.
but what I was wondering is whether its still vaild for people using form forms of in taking nicotine such as patchs, nicotine pills, and especially vap pens.

 

[sekio]

Nicotine inhibits liver metabolic enzymes no matter how it's taken.

 

[Moredopamine]

Nicotine inhibits liver metabolic enzymes no matter how it's taken.

Theoretically you are correct that whichever liver metabolic enzymes nicotine alters will be altered no matter the ROA, but a lot of the enzymatic interactions that affect the metabolism of enzymes are due to chemicals found in tobacco smoke, and not nicotine itself (e.g., caffeine clearance is accelerated in tobacco smokers, but not in people using nicotine patches/gum/whatever).

To answer the OP: If the particular interaction is due to a chemical constituent of tobacco other than nicotine, then yes, taking nicotine in other forms will not result in the same metabolic changes.

 

[ebola?]

IIRC, nicotine itself causes the effect in question, but it's again been ages since I've seen the relevant data.

ebola