• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

diacetyl-dopamine

abused L-dopa? "DOpamine Dysregulation Syndrome" probably.

If I run into some acetic anhydride I'll try triacetylating epinephrine (Primatene).
 
ebola? said:
mmm...classic direct d2 agonists tend to make people spew rather than feel euphoric (although the latter is an 'occasional' side-effect).
Click to expand...

Some individuals over at imminst were playing around with pramipexole hoping to derive antidepressant effects from it. The impetus was a study that one of them had found that showed that pramipexole worked as a potent antidepressant and synaptogenic agent when titrated up to high doses (1.5mg?) over a period of 8 - 12 weeks or something.
 
chloral hydrate said:
I still think that this compound would be worth exploring. Dopamine is a full dopamine agonist (D1,D2,D3,D4) and this is what I found about D1 agonists:

"D1-selective full agonists like SKF-81297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine"

Dopamine would also probably be somewhat like pramipexole with the D2/D3 agonism.

Say the diacetyl-dopamine does cross the BBB and gets deacetylated (I think a good bit of it should), I would think the dopamine should just be able to flood over the receptors (although it probably won't last long due to MAO, COMT, DAT).
Click to expand...

That is really interesting. I'd like to get a hold of one of these D1 agonists.
 
permastoned said:
That is really interesting. I'd like to get a hold of one of these D1 agonists.
Click to expand...

They're all so hard to make though.... If only I had some propargyl bromide, I'd be making l-selegiline out of l-desoxyephedrine (sold at walgreens as generic 50mg inhalers).
 
SKF-81297 shouldn't be difficult, should it? It shouldn't be that different than benzodiazepine synthesis, no?

Anyway, selegiline is only the l-isomer of deprenyl. I don't think there's any simple term for d-deprenyl. d-deprenyl is self administered and apparently quite enjoyable. There was a report somewhere online for it. I'll see if I can find it again. I think it was on a russian site.
 
Right I guess, well I could never do it but there are probably some patents out there like with various benzodiazepines, although I couldn't find any with a quick search engine search.

I would think d-deprenyl is very stimulant-like, right? If not active in itself, it would probably produce meth/amphetamine as a quick metabolite... well I don't know. I speak russian btw.
 
It does produce both meth and amp as metabolites. Just as selegiline produces l-meth and l-amp as metabolites.
 
Hammilton said:
SKF-81297 shouldn't be difficult, should it? It shouldn't be that different than benzodiazepine synthesis, no?

Anyway, selegiline is only the l-isomer of deprenyl. I don't think there's any simple term for d-deprenyl. d-deprenyl is self administered and apparently quite enjoyable. There was a report somewhere online for it. I'll see if I can find it again. I think it was on a russian site.
Click to expand...

Well of course, because it is metabolised into amphetamine and methamphetamine, and is also an MAO B inhibitor, it causes a nice big rise in synaptic dopamine :)
 
The l-isomer is the MAO-B inhibitor, same applies for the d-isomer? I'm not 100%sure about that. Of course pretty much anyone making it will have racemic product anyways/

These MAO-B inhibitors look very interesting. Only downside is that they all have that propargyl group which you'd probably have to buy somewhere, not very easy to make (well maybe for Hammilton its easy).

The dual MAO-A/MAO-B inhibitors could be really easily made from scratch (I'm specifically thinking of mebanazine); these seem less cool in my opinion (but maybe it's intersting to take a single dose and super happy maniac for two weeks, irreversible)
 
You must log in or register to reply here.
Top