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  • BDD Moderators: Keif’ Richards

DHC metabolism and potentiation

nAON

nAON

Bluelight Crew
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Mar 23, 2009
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Yes please.
I plan on trying some DHC soon, and i'm wondering what the best potentiaters are - so far, I have sedating antihistamines (DPH) and some benzos (yes yes I know, but I have a lot of experience mixing opis and benzos)

Now another of the popular potentiators is grapefruit juice and quinine, because they inhibit CYP. I can't find much info on DHC metabolites, so I was wondering if its recreatioal effect comes primarily from its active metabolites, or if it is itself active, and so if it would be worth getting the metabolism inhibition potentiators.

Also looking for any other opi potentiators that I may not have mentioned =D
 
tagamet my friend! others will attest to this...WGFJ works aswell, but results are highly volatile. tagamet works 100% of the time, and adds atleast 2-3 hours to the duration.

in the spirit of HR, i cannot suggest taking benzos...but! we all know what benzos and opiates feel like ;)
keep your dosage llow, i trust you know your own tolerance...

oh yah! how could i forget??? weeed weeeds and moar weeds!~!! i fucking love weed on opiates, ciggs are good to but smokable nicotine has been shown to increase the clearance of xanax, and xanax is the main benzo i use.

edit: WAIT! scratch the tagamet, i forgot DHC was a prodrug. white 100% pure grapefruit juice will be the best bet. try not to take any substrates of 2d6 before you take the DHC
 
Actuality... Alcohol, phenobarbital, etc...

These are true potentators as the cause the liver over time to break these prodrugs down more efficiently meaning a bigger bang... But sadly a shorter duration.

If you use Tagamet or WGFJ, it is best to take a slightly higher dosage.

DHC is a prodrug, correct... But, it has no ceiling dose. You can dose as high as you need to.
 
correct about the ceiling dose...good info to know :), but alcohol has been shown to only induce 2d6 in chronic drinkers.

WGFJ only inhibit 3A4 and not 2D6, unless i am mistaken?
 
nAON, give up on the snorting :D The drug particles are encased in wax, its never gonna be absorbed by your mucous membranes haha.. try plugging with warm water maybe? Or just crush as fine as poss, use bicarb etc if you like, and eat on empty stomach :)
 
Quinine would block the metabolism to dihydromorphine, though dihydromorphine might not be a signifigant metabolite is some people(usually 5% in most people) and DHC is active.Quinine is a vasodilator and mucsle relaxant that gives a strong rush when IV with heroin, hence it's a common cut in some places.Not sure what it does with DHC. Could go either way.

Grapefruit juice might work, but it will only block metabolism to nordihydrocodeine, not glucuronidation.

The best potentiator is Doriden(glutethimide), it induces CYP2D6 basically turning drugs like codeine into morphine and might inhibit glucronidation. And it a decent downer to boot. Good luck finding it, it's been pulled off the market in most nations.
 
One glass of WGFJ is more powerful than most think. It is such a strong inhibitor of enzymes that it interacts with tons and tons of drugs. Up to 24 hours in some cases.

This can be beneficial if the drug is already active.
 
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