• BASIC DRUG
    DISCUSSION
    Welcome to Bluelight!
    Posting Rules Bluelight Rules
    Benzo Chart Opioids Chart
    Drug Terms Need Help??
    Drugs 101 Brain & Addiction
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums
  • BDD Moderators: Keif’ Richards

dextromethorphan to potentiate/ lower tolerance to codeine

B

bpayne

Bluelighter
Joined
Aug 26, 2008
Messages
1,549
first of all I dont' really like dex recreationally so I will only be using it in the amount needed to get the most out of my codeine, I also have white grapefruit juice and tums, but I have suspicions the grapefruit juice will not work with the codeine although a pharmacist friend I have said it inhibits cyp34a not cyp2d6 but either way the question is simple, I don't want to ruin my codeine with a dissasociative dex trip I have lsd laying around if I really want to trip and I don't like the dex feeling anyways, so how much dex should I take to potentiate my codeine properly? and once and for all will the white grapefruit juice inhibit my morphine or increase it?
thanks
 
Ok, here goes, I just read a study that says that dxm actually inhibits cyp2d6 causing less of a conversion to morphine in Codeine, but potentiates and lowers tolerance in other opiates. I took 37 mg of dex waited an hour and then took 160 mg of codeine, I think the effect is a little diminished certainly not potentiated though, I am currently having a hit of weed and one standard alcoholic beverage to make up the difference, any notes, opinions, thoughts?
 
I never felt dex potentiated any opiates that I've used but I still used it to keep tolerance down. I almost feel like it makes opiates worse and not better. At any rate, the effect isn't that pronounced and I'll continue to use it for its anti-tolerance effects.
 
so inorder to lower opiate tolereance should one take some dex like a day before they dose? everyday? whats good with that bro?
 
About 45-60 mg, one before dosing every time. It's much better if you have a good NMDA antagonist such as memantine. Might be hard to come by though. Supposedly it instantly lowers tolerance but I find it only works when used daily.
 
I wouldn't do this the same day your taking codeine, cause I took it trying to potentiate my codeine by lowering my tolerance and it seems to have caused my cyp2d6 enzyme to metabolize LESS morphine from it.
 
bpayne said:
I wouldn't do this the same day your taking codeine, cause I took it trying to potentiate my codeine by lowering my tolerance and it seems to have caused my cyp2d6 enzyme to metabolize LESS morphine from it.
Click to expand...
You would probably have better luck with a different NMDA antagonist that doesn't inhibit cyp2d6 if you're going to be using codeine.
 
Fair enough, thats exactly why I was asking this question and leaving it open all day so someone would drop that nugget of info on me BEFORE I did it, after doing research and not finding much I decided to take the plunge, and right after I dosed the dex and the codeine I find a medline article detailing how in Codeine ONLY dex inhibits the amount of morphine produced... lol..
 
You must log in or register to reply here.
Top