Dextromethorphan (DXM) and cytochrome p4502d6

[tuplemaster]

Hey guys,

I've been using dxm for a bit over a year. During that time I've had some of the best experiences of my life. Its my favourite drug and I'd take it over heroin any day of the week.

In the past I was on fluoxetine aka Prozac, And my trips would last for days and in a word were amazing. Now however I'm no longer on Prozac and my trips are markedly more mundane, sure they are still interesting but they seem to be lacking the magic. from research I know this is because Prozac inhibits the livers enzyme system, specifically the p450 2d6 pathway.

My question is are there any substances or otc meds/supplements other than grapefruit juice that I can take to recreate my old enzyme inhibited adventures? I hate grapefruit juice with a passion and would rather drink robo!

Thanking you in advance.

 

[NeighborhoodThreat]

I'd imagine there were other interactions going on between the Prozac and DXM than just P450 2D6 inhibition.

 

[tuplemaster]

I'd imagine there were other interactions going on between the Prozac and DXM than just P450 2
D6 inhibition.

Hmm any idea what those interactions might be? I've been researching fairly extensively as of late, unfortunately there are few academic papers on the subject. I understand heightened serum levels of dxm could be a Co factor but that would come about through enzyme inhibition anyway. Perhaps a natural serotonin enhancer like St johns wart would have a similar effect. Hmm.

 

[Solipsis]

Well Prozac is an SSRI and DXM is an SRI, so this could clash - the DXM could be mellowed out because SSRI's reconfigure the way serotonin plays a role at specific sites. In some ways that can have a flattening effect, in other ways a depressing or motivating effect. Which is always why it's unpredictable if an SSRI has the right efficacy. I would abstain from serotonergic drugs so that the effect and of taking Prozac is not upset.

 

[tuplemaster]

Hmm thanks for the help. I think I'll probably just get more Prozac lol. Out of pure curiosity does anyone know of any otc p450 inhibitors? I think some anti histamines would but they have their own anti cholinergic delirium inducing effects which I personally don't enjoy.

Cheers

 

[Solipsis]

Grapefruit juice... you may want to visit the dextroverse site for more information and be careful when you start trying this.
The juice contains furanocoumarins which interact with several P450 isoforms.