Harm Reduction Developing an uncured Nicotiana rustica oral preparation to combat Mapacho smoking and Rapé snorting harms.

[Asante]

Nicotiana rustica (indian tobacco) can be grown in your windowsill in 60 days. 1gr of dried uncured leaf = 20 oral portions = a pack of cigs or a tin of snus.
Fast-dried uncured leaf orally has almost no carcinogens & associated toxins - the organic, traditional amazon basin way of pre-snort/smoke usage.

Introduction​

Nicotiana rustica, known for its high nicotine content, has been used for centuries in traditional spiritual and medicinal practices. Unlike modern commercial tobacco, it delivers a more intense yet natural nicotine experience. This refined blend optimizes the sensory and pharmacological effects of Nicotiana rustica by balancing its potency with milk powder, cocoa powder, and sodium bicarbonate. The result is a smooth, effective, and palatable formulation for oral absorption, providing sustained nicotine delivery without the harshness of raw tobacco.

Refined Blend Composition​

This formulation enhances nicotine bioavailability while maintaining a balanced taste profile through milk and cocoa powder.

Ingredient	Amount per 10g blend	Purpose
Nicotiana rustica powder	10g	Primary source of nicotine and alkaloids
Full milk powder	8g	Neutralizes tannins, smoothens taste
Cocoa powder	1g	Adds depth, bitterness balancing, polyphenol synergy
Sodium bicarbonate (NaHCO₃)	1g	Enhances nicotine bioavailability by increasing pH

Dosage: 100 mg per Use​

For controlled and sustained effects, 100 mg of this blend is placed on the tongue, allowing the active compounds to be absorbed through the oral mucosa. This ensures a gradual nicotine release, avoiding the rapid spikes associated with smoking or snuff use.

Sensory Experience: Taste, Texture, and Mouthfeel​

Initial Contact (0-10 Seconds)​

• Creamy, slightly chalky mouthfeel from the milk powder.
• Mild bitterness from cocoa and tobacco, softened by dairy proteins.
• A subtle, tingling sensation due to sodium bicarbonate.

Flavor Development (10-60 Seconds)​

• Cocoa and milk mask excessive astringency, creating a rich, earthy, dark chocolate-like profile.
• Nicotiana rustica releases alkaloids, resulting in a mild numbing effect on the tongue.
• Sodium bicarbonate amplifies freebase nicotine release, intensifying the effect without excessive harshness.

Peak Taste & Full Absorption (1-5 Minutes)​

• The nicotine effect becomes pronounced, accompanied by a warming, slightly energizing sensation.
• Cocoa leaves a faint, lingering dark, nutty aftertaste, preventing an overly dry or sharp finish.
• A balanced bitterness remains, but is significantly softened compared to unprocessed Nicotiana rustica.

Pharmacological Effects: Nicotine Absorption & Systemic Response​

Nicotine Content and Bioavailability​

• 100 mg dose contains approximately 5 mg nicotine, assuming a 10% nicotine content in Nicotiana rustica.
• Sodium bicarbonate increases pH, improving nicotine freebasing and absorption.
• Estimated absorption via oral mucosa: 40-70%, resulting in 2-3.5 mg of effective nicotine intake per dose.
• This equates to 1-2 cigarettes’ worth of nicotine, but delivered gradually over 5-15 minutes.

Timeframe	Effect
0-1 minute	Subtle tingling, first nicotine uptake
1-5 minutes	Nicotine absorption peaks, mental clarity, mild euphoria
5-15 minutes	Sustained stimulation, enhanced focus
15-30 minutes	Gradual decline, residual alertness remains

Comparative Nicotine Absorption​

Consumption Method	Nicotine Absorbed (mg)	Effect Profile
This oral blend (100 mg dose)	2-3.5 mg	Smooth onset, sustained stimulation
Cigarette (1 unit)	1-2 mg	Quick spike, rapid decline
Snuff (100 mg dose)	3-6 mg	Fast and intense
Chewing tobacco (100 mg)	2-5 mg	Long-lasting, stronger effect

Advantages of This Optimized Formulation​

Improved Sensory Experience​

• Bitterness is balanced by milk proteins and cocoa, reducing harshness.
• No excessive tannic astringency, resulting in a smoother mouthfeel.

Enhanced Nicotine Release & Efficiency​

• Sodium bicarbonate optimizes pH, maximizing nicotine absorption.
• Gradual, controlled release prevents overwhelming stimulation or nausea.

Cocoa Synergy: A Unique Addition​

• Cocoa contains theobromine, a mild stimulant that synergizes with nicotine.
• Flavonoids in cocoa contribute to a more balanced, sustained mental focus.

Conclusion​

This refined Nicotiana rustica oral blend presents an optimized way to experience nicotine absorption through a carefully formulated balance of potency, taste, and efficiency. By incorporating milk powder, cocoa, and sodium bicarbonate, the blend ensures controlled release, improved bioavailability, and a smoother sensory profile. The result is a rich, mildly bitter, yet creamy experience, delivering a sustained nicotine effect ideal for cognitive focus and relaxation.
With this formulation, oral Nicotiana rustica consumption becomes a refined and controlled alternative, avoiding the harshness of raw leaf while maintaining its potent stimulant benefits.

 

[Asante]

Oral Experience of Nicotiana Rustica Alkaloids vs. Nicotiana Tabacum and Pure Nicotine

1. Alkaloid Profile & Pharmacological Impact

Nicotiana rustica contains a broader range of alkaloids than Nicotiana tabacum and pure nicotine, making it more psychoactive and intense. Rustica can have up to 10 times the nicotine content of tabacum and includes secondary alkaloids like anabasine and myosmine, which contribute to altered states of consciousness at higher doses.

• Nicotiana rustica: Contains nicotine, nornicotine, anabasine, anatabine, and myosmine, with a nicotine content of 6-12%. Produces strong stimulation and can have entheogenic effects in high doses.
• Nicotiana tabacum: Contains nicotine, nornicotine, and anatabine, with a nicotine content of 1-3%. Provides milder stimulation and light euphoria.
• Pure nicotine: Contains only nicotine at 99+% purity. It provides a strong but flat stimulation without additional psychoactive effects.

1. Oral Absorption & Sensory Effects

The absorption rate, pH level, taste, and mouthfeel differ significantly among these forms of nicotine.

• Nicotiana rustica absorbs moderately fast (5-15 minutes) with a pH range of 6.5-8.5, which can be increased with bases for better absorption. It has an earthy, bitter, and smoky taste with a rough, slightly numbing mouthfeel. The nicotine kick is strong but builds up gradually.
• Nicotiana tabacum absorbs more slowly (10-30 minutes) with a pH of 5.5-7.5, resulting in lower absorption. It has a milder, nutty, and slightly sweet taste with a smoother mouthfeel. The nicotine effect is gentle and gradual.
• Pure nicotine absorbs very quickly (1-3 minutes) with a pH of 8-10, allowing maximum absorption. However, it has a sharp, burning chemical taste that can be unpleasant, and its nicotine kick is immediate and intense.

1. Psychoactive & Entheogenic Effects

The psychoactive effects of these substances vary significantly, with rustica standing out as the most potent and complex.

• Nicotiana rustica provides very strong stimulation that can be overwhelming. It enhances mental focus in a deep, sometimes trance-like manner and can have visionary effects at high doses. It may also cause increased heart rate, sweating, and nausea if overused. The effects last 30 minutes to 2 hours.
• Nicotiana tabacum offers moderate stimulation with mild euphoria and improved focus. It has a more relaxed effect and a shorter duration of 20 minutes to 1 hour.
• Pure nicotine provides strong but short-lived stimulation. It is purely functional and lacks depth. The peak is quick, but it may cause dizziness or discomfort. The effects last 15 to 45 minutes.

Entheogenic Properties of Rustica:

• At low doses, rustica enhances sensory awareness and deep focus.
• At moderate doses, it induces a meditative or trance-like state, making it useful for spiritual and shamanic practice.
• At high doses, it can produce visual and auditory changes, especially when combined with fasting or deep meditation.

In comparison, tabacum is more relaxed and lacks significant psychoactive properties, while pure nicotine is purely a stimulant without entheogenic effects.

1. Comparison of Applications

• Rustica is well-suited for spiritual and ritual use due to its visionary effects.
• Tabacum is a good option for mild stimulation and everyday nicotine intake.
• Pure nicotine is best for those looking for a functional stimulant but is not enjoyable to consume.

1. Conclusion: Which is Best for Oral Use?

• For a deep and intense experience: Nicotiana rustica (total alkaloids).
• For a mild and pleasant nicotine effect: Nicotiana tabacum (total alkaloids).
• For a pure and functional stimulant: Pure nicotine.

Nicotiana rustica is the most powerful and unique option, but it requires careful dosing due to its strong stimulant and entheogenic properties. It is not suitable for casual nicotine users but is valuable for those seeking spiritual depth and heightened awareness.

 

[fairnymph]

Interesting! I would try this. I hate smoking, and I hate the nasty gums and lozenges, but nicotine can definitely be useful.

 

[Asante]

You're seeing what i'm saying! Nicotiana rustica can readily be grown in large quantities almost for free ald legally, its unsuitable for smoking because you'll vomit your lungs out - so it will kick an ex smoker square in the nuts if they try to expose their lungs to it. Its a small plant, easy grower, ready in 60 days, you dry the leaves rapidly without curing like its parsley, then powder them and add additives if desired, or take 50mg or so raw on the tongue.

The alkaloid spectrum is wide and its a dyed-in-the-wool entheogenic effect, not something you'd use casually because you have to stop what you're doing if you're going to do this.

Even if you were to take 50mg leaf once a day - you are talking about using less than 20 grams dried leaf per year, totally a windowsill affair.

If you kicked tobacco but like to give Nicotiana a second chance, or go from abusing your body with tabacum towards doing it right with rustica - or want to begin something between you, the plant and the sun, ,without funding the whole death industry of tobacco, this is something else.

This year I will cultivate, experiment more, and write a free PDF that's fun to read and presents a method that doesnt rape your body or the plant by toxifying "curing" and wrongful ROAs.

I havent smoked in 10 years, this winter i experimented with 1-4mg oral lozenges once a day, every other day or so, to see whether it avoided addictive loops and selfdestructive behavior - and to warm my 52 year old body up to the notion that there will be nicotine again, but then, used like a responsible adult instead of smoke inhalation or snorted high menthol madness.

Its unimpressive and easily forgotten to take your daily lozenge. You have to sit and make it special meditatively to make it special.

Rustica will be more shamanic!

Might even take 30mg of that, given mapacho experimentation. It has so much personality.

Everything shit about rustica comes from you trying to smoke it or stuff it up your nose in a cured/rotted state.
Curing = render it abusable so you can molest your body with it.

Extreme nicotine is 100% positive if you only take a tens-of-mg dose in your mouth. The whole complaint "its unsmokable" is madness. Cayenne pepper is unsnortable. yeah, you're not supposed to, so why do it?

 

[fairnymph]

I look forward to seeing your continued work on this project. I’ll grow a plant on my own once I’ve moved. I’ve been wanting to try growing various nicotiana anyway because it’s useful as a natural pesticide. And I agree with you that it’s a drug that should be able to be used without all the damage of modern toxic cigarettes.

 

[Asante]

There is no nicotiana better for pest control than Rustica. In Russia they still sell pouches dried makhorka you can make a tea of to spray your plants with, but its common knowledge these cheap pouches end up with people without gardens It's a loophole.

The spirits call me to do this project and make that pdf so that the growing interest in alternative rational nicotiana use and Mapacho and Rapé can have a short sweet free guidebook that enables people to break free from the death industry of nicotiana abuse and have a fresh start - a pinch of herb in the mouth, like centuries ago, before all the abuse and exploitation.

Turn a new leaf

 

[Asante]

I just sucked on a small minty lozenge containing 4mg nicotine as 12mg nicotine bitartrate dihydrate. I sat back from my laptop, i feel a calm come over my mind, i feel just about every muscle in my body relax peacefully. I get contemplative. Its a bit sharp, It gave me a few hiccups. My whole body feels relaxed and pacified. It activates β2-receptors so completely opposite to smoking and vaping it indirectly bronchodilates a bit in this low transmucosal dose, easing breathing. I have a mild but through-and-through sense of relaxation while more alert. My digestion is actuated a bit, pee and poo is in my future, and the slight indigestion of having drank too much milk and juice, eases.

This is comparable to 50mg rustica leaf but much more shallow in effect than that.

It provides a calming once-a-day moment lasting maybe an hour, that is especially pleasant to either calm down after activity or letting a meal settle.

I agree fairnymph - it should be possible to have a nicotiana moment without it ruining your day through destructive ROAs, harm and strong addiction.

Almost all harm of tobacco comes from how its "cured" and how its abused in toxic ways.