• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Deuterated analogs

R

Renald

Bluelighter
Joined
Jul 8, 2015
Messages
220
What do you think, would deuterated analogs of current drugs have similar pharmacodynamics as "typical" hydrogenated.
Also, if we changed C, N, O with another isotope?
 
There are a couple deuterated drugs out there. Deutetrabenazine comes to mind. It does have a longer half life and appears to be somewhat better tolerated. But part of that is because Huntington's (horrible disease) has been quite difficult to manage, so they'll try a lot, even deuterating a 50-year old drug. Newer, other approaches are more exciting.

Most of those other isotopes in use happen to be radioactive, and can be part of nuclear medicine. C13 has been explored some.
 
And if we changed all (or some) of hydrogens to deuterium in some psychoactive drug? Maybe some of them still maintained the same action?
 
Deuterated chloroform is less toxic than the one with a 1H atom, probably because having a heavier hydrogen atom affects the bond dissociation and formation of reactive metabolites.



There probably exist some compounds with binding affinities that depend to large degree on the neutron number of the constituent atoms.

Binding Isotope Effects: Boon and Bane - PMC

Kinetic isotope effects are increasingly applied to investigate enzyme reactions and have been used to understand transition state structure, reaction mechanisms, quantum mechanical hydride ion tunneling and to design transition state analogue ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
 
You must log in or register to reply here.
Top