desmethyl-methoxetamine

[dip12]

I know methoxetamine is novel and unexplored pharmacologically but I would imagine there must be a relatively large amount of research on ketamine derivatives.

So would creating hydroxyl-arylcyclohexylamine's or desmethylmethoxetamine for example abolish activity or might it create a stronger opiate compound as in the case of desmethyltramadol?

There might be no information on this but it seems like something some people might know about, would guess desmethyl-methoxetamine might be a metabolite of methoxetamine (by logical assumption) whether or not it is active?

dip

 

[pofacedhoe]

i'm pretty sure you're talking nonsense as methoxetamine is not really an opiate

 

[ebola?]

Er....where are you demethylating the compound? I see a methoxy group on the 3 position of the phenyl ring, and an ethylamino group on the 2 position of the cyclohexane ring.

Limited data suggest that the 3-phenyl-hydroxylated arcyclohexamines hold greater selectivity for the opioid system.

Pretending that tramadol and methoxetamine have the same structural backbone (it's not clear that they do), methoxetamine is already 'desmethylated'.

ebola

 

[dip12]

Limited data suggest that the 3-phenyl-hydroxylated arcyclohexamines hold greater selectivity for the opioid system.

Really? Interesting. It would certainly be interesting to know for example if methoxy is preferred due to lipophillicity or whether the hydroxy would make an equally viable NMDA antagonist.

..and yes I was referring to desmethyl (taking the methyl away) from the methoxy group on the phenyl ring. In other words the psuedo analogous position as demethyltramadol (I appreciate the structures are different enough to not share direct comparison)