0-desmethyltramadol was stopped because there was a patent and the holder of that patent (Grünenthal GmbH) forced the stopp of production and selling
totally makes sense! The big pharmaceutical companies have a LOT more legal clout (and knowledge) than the non-clued up police/drug laws. If someone set up an RC website selling duloxetine - Eli Lilly would knock them down before they had even chosen a domain name. (well parallel imports are allowed and sometimes generics from countries with different laws but you get the picture)
Methopholine and/or its derivatives might be promising since they are not ultra-potent like the fent analogues (so less chance of people accidentally offing themselves with a tiny amount of powder)
Methopholine is an isoquinoline derivative which is not structurally related to most other opioids.It has around the same efficacy as an analgesic as codeine, and was evaluated for the treatment of postoperative pain, but never commercialised. WIKI
It's the "NEVER commercialised" part that is concerning here. Why was it never commercialised? Morphine, fentanyl your classics - used every day, untested RC opioid with addictive tendancies - I.e repeat dosing -
no thanks!
The first True designer drug to be made was actually an opioid! IIRC it was methylfentanyl.
Precisely, nice clean modification of a well established product. Interestingly to point though it was distributed via traditional routes (not RC vendour websites). If an ingenious chemist creates an opioid that happens to be safe AND legal (likely quick modification of current drug), doubt they would be setting up a nice user friendly website buyyourRCopioidshere.com - they would ship it off to the big chief or however these things work etc. (in the process covering their own legal back and not taking responsibility for distribution). You'll notice though when pharmaceutical companies apply new patents for drugs, they pateny the synthesis, the metabolites, the analogues, everything. Hoffmann–La Roche lost out quite famously with benzos when other companies realised all the metabolites (mostly of diazepam and chlordiazepoxide) were in fact active drugs that could be commercialised, result: patent, patent, patent
If they'll sell 4-MMA, they'll sell opiates too.
4-MMA doesn't leave you gagging for another hit, RC opioids however toxic may well do. It's also about publicity-ethics (not just ethics of in-it-for-the money RC sites) - NEWS: "A website sells addictive opioids" - shut down in weeks (if only by the internet hosting company!)
Opioids are BIG business in the pharmaceutical world. If they design one which is SAFE and EFFECTIVE, they are going to patent the hell out of it, it's analogues, it's metabolites. [Classic error on Janssen Pharmaceutica part to not include substitutions in it's patent + alert the authorities of such potential analogues] Clandestine-RC-chemists are competing with the BEST of the BEST. There only hope would likely be some with tramadol'esque compound if they got there in time (but again safety + efficacy as well as the chemist [or buyer asking for china-synth] would have to be that way inclined)
Finally you'll notice A LOT of the Benzos/GABA type compounds being sold are very insoluble or hard to dose. e.g phenazepam is rediculously insoluble in water. If phenazepam had been soluble in water it would have been banned by now (been available for a LONG time) due to all the DATE rape allegations surrounding it and the unscrupulous uses of it.
RC chemicals are following classic survival of the most "socially acceptible" & "legally possible" rules.
[just waiting for the next why cant we have RC-OPIOIDs? thread, 2 weeks, 2months, it'll be a coming!
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