Deprenyl + various of stimulants - report

[nidhogg]

First of all i'd like to share my experience to shine some light in the clusterfuck of negative reports consisting of deprenyl + pea or other substances.
I have never used a stimulant before that provided the effects i experienced today, so i cannot compare it to amphetamine or similar.
I have been running deprenyl 15mg in total for a week prior to trying this.

The problem here is that i do not know the exact dosage of the stims i use as i dont have them in free form, instead, they are all mixed in a pre workout drink i had leftover. Although i can provide a guideline. One scoop consisted of the following (relevant) substances:

377mg of PEA analogues + others, division of substances unknown:
R-beta-methylphenylethylamine
beta-phenylethylamine
L-tyrosine
Hordenine HCL < reported to have reversable mao-b inhibition attributes
Folic Acid < Vitamin B9
Caffeine < probably no effect in this case

Also a hint of vitamin B6:
Vitamin B6 250% of RDI (5mg~ probably insignificant)


T0 - So i mixed a scope in a glass of water and started by ingesting half of it first(empty stomach), just to be safe as i have learned the hard way from experimenting with tryptamines.
T15 - I was suddenly struck by feeling of well being. Mood increased significantly and i felt very energized(mind-wise). Started singing and listening to music.
T30 - I was determined to go even further, so i decided to take two more gulps as i tought to myself (do you know what you are doing?). And man, am i fucking glad i did!
T40 - Everything i felt earlier was enhanced 10fold. Seriously i cannot explain in words how fucking good i felt. My social cognitive functions increased just as much and im normally a withdrawn guy. Focus and "intensity" increased aswell, not sure how i would explain this, but i felt like i could comprehend stuff faster than i usually can.
T60 - I went to work out and on the way i felt really damn good and open, spontaneously hitting on chicks and greeting familiar faces. I bet they thought "what the fuck is this guy on?"

Basically i had a blast in the gym, came home after 2 hours and felt really tired. Is this the crash people are talking about? I cant determine whether this is from my stimulant cocktail or just exhaustion from lifting weights, but my mood is still elevated and still feel good but ofc not even a fraction of what i felt earlier. And best of all? I had zero side effects, never felt any nausea, headache, BP increase, heart rate increase etc NADA.

If anyone has any information on R-beta-methylphenylethylamine regarding its metabolism etc, please share. Next week im going to get myself B6, DLPA/LPA and perhaps the two phenylethylamine analogues for further experimentation.

 

[ebola?]

You did not start with a low dose, but you were lucky and had a good experience.
Please be careful. I'll also link-whore my FAQ, like usual:
http://www.bluelight.ru/vb/showpost.php?p=7659100&postcount=5

ebola

 

[Jamshyd]

This is about as irresponsible as it gets.

Using MAOis is risky as-is.

Using it with SCOOPS of things known to interact severely with it, some of which are almost unresearched, is just looking for trouble.

 

[ebola?]

You're right, but I've been stern enough lately, that I fear becoming near sanctimonious.

Titrating one of the candidates for potentiation Shulgin style in isolation would have been vastly safer. Perhaps "really lucky" would have been operationally appropriate with this case.

ebola

 

[nidhogg]

This is about as irresponsible as it gets.

Using MAOis is risky as-is.

Using it with SCOOPS of things known to interact severely with it, some of which are almost unresearched, is just looking for trouble.

What is so unresponsible about it?

L-tyrosine & pyridoxine is constantly used with mao-b
B-MPEA is simply amphetamine but metylated on the beta carbon istead of alpha. Its not going to change affinities just because of that, but it is going to be broken down by mao-b which it is.
PEA...everyone has heard of it, everyone has tried it. Naturally occuring in the brain and its effects are farily studied and known, nothing strange here.

The only substance here that "could" cause potentional dangers is hordenine, but its still naturally occurring..you decide.

Other than this there was nothing which would interract with mao-b, i.e. creatin whey protein etc.

In all your posts you keep mentioning maois here and maois there, well let me spill the beans for you. Not to be a smartass but you cant judge all alike, learn the difference between mao-b and mao-a, thank you

Or maybe you are trying to say that companies dont tell what they put in their supplements, well i could say the same about practially anything

You're right, but I've been stern enough lately, that I fear becoming near sanctimonious.

Titrating one of the candidates for potentiation Shulgin style in isolation would have been vastly safer. Perhaps "really lucky" would have been operationally appropriate with this case.

ebola

What is your definition of a low dose? 377mg where there most likely is 100mg caffeine, and next highest most likely being l-tyrosine. leaves out a possibility of 50~mg PEA and even less b-MPEA because its expensive. When people try deprenyl + pea they try 100-150mg. It IS low dosed.


Overreacting much? 8)

 

[Jamshyd]

Oh wow, it seems you don't even realize what deprenyl does?

 

[nidhogg]

Metabolizes to dimethylselegiline which together with selegiline increases synthesis of NGF, BDNF and GDNF which simply put increases sensitivity to neurons. Inhibits mao-b in low/normal doses and mao-a+b in higher. Partly metabolizes to l-meth/amphetamine which has insignificant effects due to its low concentration.


Why dont you take your time now and tell me why "using big scoop of things" is so dangerous to you when 99% of that scoop is completely irrelevant to the subject

 

[Jamshyd]

So you do know, yet you happily go about taking scoops of substances that could potentially lead to hypertensive crisis?

And note that the dose of selegiline you're taking may very well be inhibiting MAO-A?

Also, you happily tell us that these substances are all metabolized by MAO-B, yet also realize that selegiline primarily inhibits that enzyme?

Do you not notice how your logic is entirely self-contradictory?

You are plain irresponsible. I don't care how many acronyms you can spell out.

 

[ebola?]

Okay. I already ostentatiously linked the FAQ I wrote, but it seems that 'we' still lack an understanding fo what we're putting your neurology through...

L-tyrosine & pyridoxine is constantly used with mao-b

Yes, and to varying effects, sometimes involving severe cardiovascular strain.

B-MPEA is simply amphetamine but metylated on the beta carbon istead of alpha. Its not going to change affinities just because of that

We'd expect very different effects, namely beta-adrenergic agonism coupled with norepinephrinergic release. This effect-profile is very dangerous in combination with selegiline.

PEA...everyone has heard of it, everyone has tried it. Naturally occuring in the brain and its effects are farily studied and known, nothing strange here.

When combined with inhibition of maob, phenethylamine acts totally differently, more akin to a shorter acting amphetamine with more severe side-effects (and with unpredictable potency).

Not to be a smartass but you cant judge all alike, learn the difference between mao-b and mao-a, thank you

We both did, and we both concluded that you acted recklessly....

You were LUCKY....

ebola

 

[nidhogg]

So you do know, yet you happily go about taking scoops of substances that could potentially lead to hypertensive crisis?

Lol you still keep using "scoops of substances", its a scoop of protein containing extremly small traces of substances, thank you.

And note that the dose of selegiline you're taking may very well be inhibiting MAO-A?

General guideline shows >10mg/day to inhibit mao-a aswell, newer studies show that 20mg/week MAY inhibit mao-a. I am taking 15mg/week which equals to less than 2.5mg/day(i skip one day) So yeah, i think im pretty safe when it comes to mao-a activity

You are plain irresponsible. I don't care how many acronyms you can spell out.

You can call me irresponsible if you want, but when you write empty statements like that its kind of hard to take you seriously.

Okay. I already ostentatiously linked the FAQ I wrote, but it seems that 'we' still lack an understanding fo what we're putting your neurology through...

I have read your faq pretty thoroughly, but it only states do's and dont's. Im only interested in on thing and that is WHY?

Yes, and to varying effects, sometimes involving severe cardiovascular strain.

Pyridoxine has showed zero interactions. L-tyrosine has showed rapid heart beat in people who take just as much on selegiline as they would without.

We'd expect very different effects, namely beta-adrenergic agonism coupled with norepinephrinergic release. This effect-profile is very dangerous in combination with selegiline.

I stand corrected and i couldn't agree more, norepinephrines effect on cardiovascular vasoconstriction combined with B1 adrenergic stimulation could be potentially dangerous leading to hypertension. But b-MPEAs binding scheme is unexplored and it may very well have zero to very little affinity to B1. Is this what you meant by lucky?

When combined with inhibition of maob, phenethylamine acts totally differently, more akin to a shorter acting amphetamine with more severe side-effects (and with unpredictable potency).

Wait, what? Acts differently how? PEA does the same with our without mao-b inhibition, it acts as a neuromodulator for dopamine and norepinephrine. The only "diffrent" thing would be that it would take longer for the body to dispose of the extra dopamine and norepinephrine due to selegiline.

We both did, and we both concluded that you acted recklessly....

You were LUCKY....

Lol yet again do you put yourself in the center of attention, i know that you know a shitload about this whole subject. I was just reacting to Jamshyd's type of writing which would seem as if he wrote everything off a book with zero understand of what the hell he was talking about. Have some basis for your statements next time, Jamshyd.

 

[Jamshyd]

- snip -
People like you give us all a bad name and paint a skewed picture of us in the media and the eyes of everyone.

 

[His Name Is Frank]

Calm down, Jam Master Shyd. He's a noob. He'll learn. Let's keep this thread on topic and not turn this into a free-for-all. If anything, nidhogg's report will hopefully serve as a warning for others.