selegimuppet
Greenlighter
- Joined
- Aug 23, 2018
- Messages
- 1
Hello,
Hope I've posted this in the right section.
I initially tried a simplistic approach to try and work this out: a person has a certain amount of MAOB doing its thing in the brain and it is cycled slowly enough that it can be approximated as not being in an equilibrium with regeneration/inactivation over a short time scale. Basically there are just a certain number of protein molecules there.
5mg of deprenyl (mol wt: 187.3 g/mol) is 0.005/187.281 = 0.0000267 moles, Avogadros number: 6.02214?1023 mol−1 x 0.0000267 = 1.6 x 1019 molecules. That's a shitload, I can't imagine that many large proteins so much deprenyl must be bound up, metabolised, unavailable and this will be variable between individuals.
Well I'm none the wiser after that so I'll just ask outright! Does anyone know vaguely, the dose required to fully saturate MAOB (and no more), and a dose that will only HALF saturate MAOB?
Are there noticable possitive effects at partial blockade?
Surely it is safer to maintain some of this pathway operating?
Does the body compensate for Deprenyl binding by synthesising increasing amounts of MAOB? A tolerance effect.
All the best!
Hope I've posted this in the right section.
I initially tried a simplistic approach to try and work this out: a person has a certain amount of MAOB doing its thing in the brain and it is cycled slowly enough that it can be approximated as not being in an equilibrium with regeneration/inactivation over a short time scale. Basically there are just a certain number of protein molecules there.
5mg of deprenyl (mol wt: 187.3 g/mol) is 0.005/187.281 = 0.0000267 moles, Avogadros number: 6.02214?1023 mol−1 x 0.0000267 = 1.6 x 1019 molecules. That's a shitload, I can't imagine that many large proteins so much deprenyl must be bound up, metabolised, unavailable and this will be variable between individuals.
Well I'm none the wiser after that so I'll just ask outright! Does anyone know vaguely, the dose required to fully saturate MAOB (and no more), and a dose that will only HALF saturate MAOB?
Are there noticable possitive effects at partial blockade?
Surely it is safer to maintain some of this pathway operating?
Does the body compensate for Deprenyl binding by synthesising increasing amounts of MAOB? A tolerance effect.
All the best!