This is a quote from a linked article. Make of it what you will
Abstract
Diet-induced obesity is associated with fatty liver, insulin resistance, leptin resistance, and changes in plasma lipid profile. Endocannabinoids have been implicated in the development of these associated phenotypes, because mice deficient for the cannabinoid receptor CB1 (CB1-/-) do not display these changes in association with diet-induced obesity. The target tissues that mediate these effects, however, remain unknown. We therefore investigated the relative role of hepatic versus extrahepatic CB1 receptors in the metabolic consequences of a high-fat diet, using liver-specific CB1 knockout (LCB1-/-) mice. LCB1(-/-) mice fed a high-fat diet developed a similar degree of obesity as that of wild-type mice, but, similar to CB1(-/-) mice, had less steatosis, hyperglycemia, dyslipidemia, and insulin and leptin resistance than did wild-type mice fed a high-fat diet. CB1 agonist-induced increase in de novo hepatic lipogenesis and decrease in the activity of carnitine palmitoyltransferase-1 and total energy expenditure were absent in both CB1(-/-) and LCB1(-/-) mice. We conclude that endocannabinoid activation of hepatic CB1 receptors contributes to the diet-induced steatosis and associated hormonal and metabolic changes, but not to the increase in adiposity, observed with high-fat diet feeding. Theses studies suggest that peripheral CB1 receptors could be selectively targeted for the treatment of fatty liver, impaired glucose homeostasis, and dyslipidemia in order to minimize the neuropsychiatric side effects of nonselective CB1 blockade during treatment of obesity-associated conditions.
What I take away from this is that there are two different types of CB1 stimulation; endogenous and exogenous. Endogenous stimulation is likely part of the body's signalling systems. Exogenous stimulation > shitty diet, drugs and perhaps other environmental factors. External stimulations of CB1 receptors are probably not all equivalent.
I've been all dialysis 3.5 yrs and have blood work every 3-4 months or more if my dialysis unit wants it. Mostly concerned with renal biochemistry but they always look at liver enzymes, blood glucose levels, etc
I've got 5 people that I see or are part of my dialysis care; nurse, pharmacist, psychiatrist, nephrologist and social worker. My psychiatrist is the only individual who has expressed concern over my cannabis use - and it's b/c of the potential to cause panic attacks.
@Freudzilla I don't know how comfortable you feel talking to your doctor; perhap ask for references if possible or peer reviewed published sources.
Tom
I’d think they’d get a higher concentration somewhere but who am I to judge.
