Degree of Rolling and Adverse Effects on Your Brain

[OGKooosh]

If you don't roll very hard, what does that mean as far as neurotoxicity and serotonin levels? Last weekend I rolled (unplanned, this was supposed to be my month off) but not hard at all the dose was quite low (~.1). The reason I ask is because I try to moderate my MDMA use and there is a pretty big show coming up next month that I would simply love to roll at, but I also don't want to do any damage to myself. Thoughts?


Also in the time before my most recent roll I rolled hard as shit and paid for it the next couple of days, after last weekend I haven't had any depression, I guess its the upside to not rolling that hard haha.

Also I don't have any plans to roll in April... at least not yet, but as i'm sure you all know something always seems to come up haha.

 

[shiznik]

There are studies suggesting a single recreational dose does not cause any damage, and studies that state the opposite. Nobody knows the answer to your question for sure.

 

[shreem]

think about coffee
meat eating
milk and dairy
these things can be just as bad over time as once in a while having mdma

the studies are funded by people with an agenda hell bent on persecution so do you trust them ? the only evidence , that i know of about it being bad for you is based on giving monkeys meth, then when the monkeys got brain damage they said "this is from mdma "
now , i am not terribly aware of mdma effects, but i will tell you just don't worry about it, if you notice it is making you messed up after the dose ends then stop doing it

booze is way worse for your entire body than mdma could ever be , based upon how easy it is to die from and how horrible it makes you feel the next day , i really do not see a reason to think that this is anything , but i have not ever used it , to be that concerned about , presuming it does not have meth or etc in it

wanna know what damage caffeine does to your CNS ? yikes !

put faith in being healthy and whadda ya know
put faith in the opposite and sucks to be you
either way , what you look for you become .

 

[AylaV]

either way , what you look for you become .

This is about the only thing you said I agree with. You are ultimately the creator of your own perception.

the studies are funded by people with an agenda hell bent on persecution so do you trust them ? the only evidence , that i know of about it being bad for you is based on giving monkeys meth, then when the monkeys got brain damage they said "this is from mdma "
now , i am not terribly aware of mdma effects, but i will tell you just don't worry about it, if you notice it is making you messed up after the dose ends then stop doing it

Rikaurte's study may be false, but there is a plethora of other studies into 5ht axon degradation that are not "meth monkeys". MDMA is neurotoxic. I agree that its harm is often overstated and that Rikaurte's study is often (still) quoted as fact when it dealt with large amounts of a completely different chemical.

booze is way worse for your entire body than mdma could ever be , based upon how easy it is to die from and how horrible it makes you feel the next day , i really do not see a reason to think that this is anything , but i have not ever used it , to be that concerned about , presuming it does not have meth or etc in it

This I agree with to some degree. Ethanol AND MDMA have hepatotoxicity, however I'm certain that ethanol is worse as MDMA's heptatotoxicity is generally caused by "a propensity to develop exaggerated pharmacological responses due to imparied metabolism of [MDMA]" (http://www.maps.org/w3pb/new/1999/1999_jones_16_1.pdf).

What I'd be cautious with is saying one is worse than the other based on immediate effects. Cyanide and ricin are both poisonous, but ricin will take longer to kill you. Both are just as poisonous, but ricin takes days before you die. It would be naive to assume that short term negative effects somehow make something more toxic. If anything, it's the long term effects that are more worrisome as they generally take longer to recover from (post acute withdrawal syndrome, MDMA-induced depression, etc.).

 

[AndroidsDreamofBTC]

If you don't roll very hard, what does that mean as far as neurotoxicity and serotonin levels? Last weekend I rolled (unplanned, this was supposed to be my month off) but not hard at all the dose was quite low (~.1). The reason I ask is because I try to moderate my MDMA use and there is a pretty big show coming up next month that I would simply love to roll at, but I also don't want to do any damage to myself. Thoughts?


Also in the time before my most recent roll I rolled hard as shit and paid for it the next couple of days, after last weekend I haven't had any depression, I guess its the upside to not rolling that hard haha.

Also I don't have any plans to roll in April... at least not yet, but as i'm sure you all know something always seems to come up haha.

I think it's okay to occasionally cheat on your "one dose of MDMA per month" rolling schedule as long you: don't make a habit out of it, take slightly longer break when doing MDMA more than once a month, eat healthy, exercise, do whatever it takes to get to the place where you want to be.

Is MDMA neurotoxic? Definitely! Does that mean rolling two times in a month will start impacting your mental performance? I think not! Just don't make a habit it out it and keep working hard (mentally and physically).

 

[rickolasnice]

There are studies suggesting a single recreational dose does not cause any damage, and studies that state the opposite. Nobody knows the answer to your question for sure.

Pretty much this when talking about single doses (~125mg).. but there are studies saying that high / repeated dosing will cause damage to 5-HT axons..

 

[thomas2laylum]

life kills