MrRoot
Bluelight Crew
- Joined
- Apr 15, 2011
- Messages
- 2,121
Hi,
I have kept my OxyContin OC* soaked in water for about an hour after I have first peeled off the first layer. I haven't noticed any difference between one hour or 12+ hours. In either case the pills itself become very bristle and they can be broken between fingers easily and the water tastes exactly like oxycodone.
Just to be sure I have digested the crushed pills too along with the water/oxycodone solution.
For some reason it does not hit as hard as when chewing the pills itself although it does indeed decrease the time needed to feel the effects. I don't want to chew them anymore since my teeth are disintegrating a little (probable from a prolonged use of opiates) and I have already chipped one tooth by chewing my oxies.
Is this a trade off between faster onset and lower high, or could I achieve stronger IRL experience high by example trying to increase the bioavailability by pouring the water/oxycodone solution to a fatty food like meatpie and then eating it? Or adding some kind of oil to the solution itself? Atleast some studies suggests that eating a fatty meal with some opiates could enhance their absorbtion through the colon.
I know that best bioavailability could be achieved by IV use, but I simply don't want to go through that route ever (exept while in hospital).
Could the high feel better by chewing because it leaves still some Extended Release abilities to the portions of the pills when comparing to that soaking method since it will get totally rid of the ER mechanism? I mean as with some substances like codeine the high can be better by repetitive doses, could same apply to oxycodone?
I can't find any pharmacological reason why this would apply to oxycodone though since only active metabolite for oxycodone, also known as dihydrohydroxycodeinone, I could think of would be hydroxydihydromorphinone through O-Desmethylation by CYP2D6 enzyme and I don't know even know how potent that would be since it would actually be something like 5 to 15 percent of weight of oxycodone that could turn into that metabolite. Of course O-Desmethylation suggest that the metabolite would be one or two times as potent per mg than oxycodone itself, if it would play well along the other O-Desmethylated opiates, but the amount converted in to it would still be only one tenth or like and therefore that metabolite would not be a huge part.
(*=which is still the only oxycodone version prescribed in my area along with OxyNorm IR although Targiniq/Targinact has been gaining some popularity among the docs since it is said to be less harmfull to the colon. Notice that they can't say more abuse proof here since any pharmaceutical company would have their import license banned by saying something as that stupid )
I have kept my OxyContin OC* soaked in water for about an hour after I have first peeled off the first layer. I haven't noticed any difference between one hour or 12+ hours. In either case the pills itself become very bristle and they can be broken between fingers easily and the water tastes exactly like oxycodone.
Just to be sure I have digested the crushed pills too along with the water/oxycodone solution.
For some reason it does not hit as hard as when chewing the pills itself although it does indeed decrease the time needed to feel the effects. I don't want to chew them anymore since my teeth are disintegrating a little (probable from a prolonged use of opiates) and I have already chipped one tooth by chewing my oxies.
Is this a trade off between faster onset and lower high, or could I achieve stronger IRL experience high by example trying to increase the bioavailability by pouring the water/oxycodone solution to a fatty food like meatpie and then eating it? Or adding some kind of oil to the solution itself? Atleast some studies suggests that eating a fatty meal with some opiates could enhance their absorbtion through the colon.
I know that best bioavailability could be achieved by IV use, but I simply don't want to go through that route ever (exept while in hospital).
Could the high feel better by chewing because it leaves still some Extended Release abilities to the portions of the pills when comparing to that soaking method since it will get totally rid of the ER mechanism? I mean as with some substances like codeine the high can be better by repetitive doses, could same apply to oxycodone?
I can't find any pharmacological reason why this would apply to oxycodone though since only active metabolite for oxycodone, also known as dihydrohydroxycodeinone, I could think of would be hydroxydihydromorphinone through O-Desmethylation by CYP2D6 enzyme and I don't know even know how potent that would be since it would actually be something like 5 to 15 percent of weight of oxycodone that could turn into that metabolite. Of course O-Desmethylation suggest that the metabolite would be one or two times as potent per mg than oxycodone itself, if it would play well along the other O-Desmethylated opiates, but the amount converted in to it would still be only one tenth or like and therefore that metabolite would not be a huge part.
(*=which is still the only oxycodone version prescribed in my area along with OxyNorm IR although Targiniq/Targinact has been gaining some popularity among the docs since it is said to be less harmfull to the colon. Notice that they can't say more abuse proof here since any pharmaceutical company would have their import license banned by saying something as that stupid )