Neuroscience Deep Brain Stimulation for treatment of Substance Use Disorders

[neversickanymore]

Deep Brain Stimulation (DBS) has been shown effective for treating Parkinson's disease. It has also shown promise treating some forms of depression.

They are now looking into using DBS to treat Substance Use Disorder (SUD) and its initially showing promise. Here is some information on an initial trial for Opiate Use Disorder.

Brain implant may help fight opioid addiction when other treatments fail

Doctors at West Virginia University’s Rockefeller Neuroscience Institute are testing the experimental procedure on patients for whom other treatments didn't work.

www.nbcnews.com

Deep brain stimulation for opioid use disorder: A systematic review of preclinical and clinical evidence

Opioid use disorder (OUD) is a chronic and complex disease characterized by repeated relapses and remissions. Deep brain stimulation (DBS) has been di…

www.sciencedirect.com

Deep Brain Stimulation of the Nucleus Accumbens/Ventral Capsule for Severe and Intractable Opioid and Benzodiazepine Use Disorder - PMC

Given high relapse rates and the prevalence of overdose deaths, novel treatments for substance use disorder (SUD) are desperately needed for those who are treatment refractory. The objective of this study was to evaluate the safety of deep brain ...

www.ncbi.nlm.nih.gov

 

[neversickanymore]

Deep Brain Stimulation (DBS): What It Is, Purpose & Procedure

Deep brain stimulation is a treatment that delivers an electrical current directly into your brain. It treats movement disorders, mental health conditions and more.

my.clevelandclinic.org

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518728/

Deep brain stimulation - Wikipedia

en.wikipedia.org

 

[neversickanymore]

Deep Brain Stimulation (DBS) for Methamphetamine Use Disorder - Full Text View - ClinicalTrials.gov

Deep Brain Stimulation (DBS) for Methamphetamine Use Disorder - Full Text View.

clinicaltrials.gov

The results of this trial may provide a pretty clear indication of the power of DBS on SUD. The trial on OUD is promising, however the patient was on opiate replacement therapy with Suboxone. In this trial no replacement medication will be on board.

 

[SpiralusSancti]

I suspect it’ll have much of the same sideffects as ECT.

 

[neversickanymore]

Deep brain stimulation of the nucleus accumbens in treatment-resistant alcohol use disorder: a double-blind randomized controlled multi-center trial - Translational Psychiatry

Treatment resistance in alcohol use disorders (AUD) is a major problem for affected individuals and for society. In the search of new treatment options, few case studies using deep brain stimulation (DBS) of the nucleus accumbens have indicated positive effects in AUD. Here we report a...

www.nature.com

Treatment resistant AUD

EDIT: This study did not mention any therapy attended by patients while receiving the DBS. It would be interesting to see DBS results from a group that received addiction therapy compared to another that did not. Also, retraining cue responses is pretty easy, often totally overlooked by current rehabilitation and in fact they often provide treatment in a safe non real world environment purposely devoid of opportunity and triggers, so what effect could trigger (cue) response reprograming in conjunction with DBS have. Could be astounding.

 

[neversickanymore]

Neurobiology of Deep Brain Stimulation: Mechanisms of deep brain stimulation

Deep brain stimulation (DBS) is widely used for the treatment of movement disorders including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain treatment-resistant neuropsychiatric disorders including obsessive-compulsive ...

www.ncbi.nlm.nih.gov