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Decalin-2-yl-(1-pentylindol-3-yl) methanone?

D

Draculen

Bluelighter
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Feb 6, 2008
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Hello Bluelight,

Im wondering if anyone has heard of the chemical in the title. Descalin JWH. Ive googled my heart out but have found no information on it whatsoever. any info would be appreciated. thanks!
 
It appears to be named wrong, but sounds like the analogue of JWH-018 where the naphthalene ring system has been fully saturated to turn it into a decalin ring system instead.

I would guess that it will retain activity as a CB2 agonist but will probably have lost most of its activity at CB1, seeing as that is what happens in most cases when the benzoyl / naphthoyl is replaced by some bulky aliphatic group. Never seen the decalin analogue in the literature though.
 
Thanks for the fast reply.

Im curious to try it but if its lost most of the CB1 activity im guessing it would be much weaker then actual Jwh-018? source just popped up, have never seen an RC as cheap as this one so I may end up trying it either way. Thanks again for the reply.
 
mad_scientist said:
It appears to be named wrong, but sounds like the analogue of JWH-018 where the naphthalene ring system has been fully saturated to turn it into a decalin ring system instead.

I would guess that it will retain activity as a CB2 agonist but will probably have lost most of its activity at CB1, seeing as that is what happens in most cases when the benzoyl / naphthoyl is replaced by some bulky aliphatic group. Never seen the decalin analogue in the literature though.
Click to expand...

What compounds are you generalizing from to come to this conclusion?

I don't know of any pairs of cannabinoids to compare this to, and it's not fair to compare it to other classes of drug.

I'd be pretty impressed if it was active and good, though, because you're replacing a fairly compact, planar, napthyl group with a large, floppy, non-planar decalin group.

buy some, vape it, and tell us if it gets you high. Proceed with caution, of course, as it's pharmacology is unknown.
 
^^^

Indeed. See the relevant patent WO 2006 069196 A1 for many other examples, but I don't see a decalin substitution listed in there, and from the little pharmacological data available they seem to be mainly selective CB2 agonists.
 
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