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Database of Designer Drugs

View attachment 8514

Just to inspire

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The answer to question A is the reason it is all being posted in the first place - aspartame is easy to acquire and dirt cheap and has a very low potential for being removed from the market, at least until it is put into use making amphetamines

And the illustration was supposed to be entertaining, I think I was drunk when making it but anyways
 
blowjay said:
The answer to question A is the reason it is all being posted in the first place - aspartame is easy to acquire and dirt cheap and has a very low potential for being removed from the market, at least until it is put into use making amphetamines

And the illustration was supposed to be entertaining, I think I was drunk when making it but anyways
Click to expand...

Again:
What is sold on the supplement market is plain L-phenylalanine. D-phenylalanine (different isomers, compriende?) has no biological relevance AFAIK. You would be already lucky to find (racemic) DL-phenylalanine on any supplement market.
L-amphetamines are absolutely worthless as recreational drugs hence why L-methamphetamine was once sold as a OTC nasal decongestant and NO it does not get you high! Some dumfucks actually did abuse them as soon as they read l-methamphetamine on the label and ran home with a dozen inhalers while having orgasms for their 'great discovery' and probably ended up hospitalized. Reminds me of that dude that injected himself with a few dozen mls of boiled supermarekt poppy seeds thinking he outsmarted the heroin market and died after a week of agony.
The only relevant L-amphetamines analogues are psychedelic DOX like compounds but no one would be able to make such a thing, if you did you would probably get a Nobel Prize.

Please read something about isomers, chemestry and pharmacological activity before posting naive ways to make amphetamines on such a forum.
 
I know all about isomers and that dextro version is what is coveted, I am just trying to gain wider recognition for aspartame as a potential precursor. You can call me whatever you want but to suggest a sugar substitute as a drug precursor is already innovative in itself regardless of the particular isomer that results.

It isn't like there are only 2 possible offshoots of this as a precursor, I just wanted to show the structure and its possibilities. I refuse to be put down on this idea for aspartame as a precursor because this is so abundant comparative to what was used to make clandestine meth in the past. Seriously, sign a log book for pseudo or go to the grocery store and buy a sugar substitute without any second glance, pretty easy call on why this is a big deal.
 
it's stupid.

just start with phenylalanine. why start with the dipeptide when you can save steps and just use pa?

phenylalaline is a billion times more common than aspartame... but I suppose only if you count it in every peptide and protein it exists in.... :)
 
But what about something involving an acetal as a protecting group? Couldn't that potentially go in an interesting direction?
 
Which moiety resp. functional group do you suggest should be protected as (cyclic) acetal in which compound? - Murphy
 
Ketone in the middle of the aspartame to potentially protect so to work out something a little better in the long run. Not too sure where it could go but I feel like it loses practicality to use now for clandestine precursor, but who knows.

I'm still noobish as hell to all of this but this helps me get introduced to new concepts and thinking. Take the ideas at whatever they are worth but yeah I noticed the ketone could be protected and then maybe everything else reduced and then thats as far as I have got with the thought. Something else could take place of the reduced carboxylic acids potentially, I am kinda just throwing this out there to see what comes back.
 
Couldn't I protect it and then do some work on the carboxyl group below to make everything a little more loveable and then unprotect and use hydrolysis to give something new? I gotta get off the computer now but I think that has some potential for something fun.
 
There is no ketone in aspartame!

Looking at the 2D-picture from Wikipedia, the following functional groups are present in this molecule (from left to right): A free carboxylic acid, a primary amine, an amide, the methyl ester of a carboxylic acid. But no ketone.

Apart from this, the following quote doesn't make any sense whatsoever:
blowjay said:
Couldn't I protect it and then do some work on the carboxyl group below to make everything a little more loveable and then unprotect and use hydrolysis to give something new? I gotta get off the computer now but I think that has some potential for something fun.
Click to expand...

And finally - even if it would make any sense - synthesis discussion is completely forbidden here. Please do not cite some synthetical methods by random, this doesn't help a thing.


- Murphy
 
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